Monoclonal Antibodies as a Site Specific Particulate Drug Delivery System: A Review

Abstract

Monoclonal antibodies are antibodies that are identical because they were produced by one type of immune cell, all Human monoclonal antibody immunotherapy in clinical medicine has been an exciting prospect for some time, and increasing numbers of such antibodies have gradually become available. Targets and basic characterization of novel classes of bioactive agents, to the development of ‘designer’ or ‘smart’ materials which provide required excipient or carrier properties to achieve modulated and targeted drug delivery. Drug particle engineering, or crystal engineering, provides an additional dimension to drug delivery and targeting. Traditional methods of particle formation, crystallization. Antibodies can be heterogeneous with respect to size, charge, antigen specificity, and affinity. These factors may be significant when antibodies are used as a drug delivery system. Drug targeting and delivery using antibodies has been most useful in the field of chemotherapy because this is an area of research in which there is the greatest need for target-site specificity. Antibodies have been found to have many applications in the management of human carcinomas, including colorectal, gastric, ovarian, endometrial, breast, lung.