Urinary C-peptide Creatinine Ratio and Its Correlation with Parameters of Metabolic Syndrome

Abstract

To assess the correlation between urinary C peptide creatinine ratio with serum C peptide, serum insulin and its correlation with clinical and biochemical parameters of metabolic syndrome. A total of 100 subjects more than 18 years of age with metabolic syndrome according to ATP III criteria with 100 controls were included in a prospective observational study for a period of 1.5 years. Individual parameters of metabolic syndrome was higher in females with hypertriglyceridemia was most common and hyperglycaemia least common parameter of metabolic syndrome. Fasting urinary C peptide creatinine ratio and Stimulated urinary C peptide correlate significantly with fasting serum C peptide (p<0.01),stimulated serum C peptide (p<0.01), serum fasting insulin (p<0.01) and HOMA IR (p<0.01). A fasting urinary C peptide creatinine ratio of more than 1.8 nmol/mmol, stimulated urinary C peptide creatinine ratio more than 2.8 nmol/mmol and HOMA IR >2.7 can be used as a parameter to distinguish individual with and without metabolic syndrome. Urinary C peptide creatinine ratio correlate with serum C peptide and parameters of metabolic syndrome and can be used as a non-invasive simple tool to assess insulin resistance and also to distinguish patients with and without metabolic syndrome.