Ameliorating effect of Phoenix dactylifera on lambda cyhalothrin induced biochemical, hematological and hepatopathological alterations in male wistar rats

Abstract

Lambda cyhalothrin (LTC) is a synthetic pyrethroid insecticide, widely used to control insect pests in agriculture, public health, and homes and gardens. In the present study, an attempt has been made to study the effect of lambda cyhalothrin on biochemical, hematological parameters and ameliorating effects of palm dates (Phoenix dactylifera) in male wistar rat. Adult male Wistar rats were divided into four different groups. Group I served as control; group II received lambda cyhalothrin at a dose of 8 mg/kg (1/10 LD50) dissolved in water for 21 days orally; group III received P. dactylifera (200 mg/kg BW for 21 days) orally; group IV P. dactylifera alone treated. LTC-induced liver toxicity was measured by the increased activities of serum hepatic marker enzymes like aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, along with increased elevation of lipid peroxidation and reduction in the levels of enzymic and non-enzymic antioxidants levels. Lambda cyhalothrin exposure leads to adverse effects on hematological parameters including erythrocyte (RBCs) and leukocyte (WBCs) counts, hemoglobin concentration (Hb), hematocrit (Hct) and blood indices (MCV and MCH). However, treatment with P. dactylifera normalized the levels of hepatic markers, antioxidant and non-enzymic antioxidant, lipid peroxidation products and all the hematological parameters. These findings highlight the efficacy of P. dactylifera as protective effects against lambda cyhalothrin induced toxicity.