Extended Hildebrand solubility approach and Yalkowsky-Roseman model for estimating the solubility of sulfadiazine and sulfamethazine in some {ethylene glycol (1) + water (2)} mixtures at several temperatures
Martha Sofía Vargas-Santana, Ana María Cruz-González, Néstor Enrique Cerquera, Alana Sofia Escobar Rodriguez, Rossember E. Cárdenas, Omar Calderón-Losada, C. Ortiz, D. R. Delgado
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Abstract
Aim: extended Hildebrand Solubility Approach (EHSA) and Yalkowsky Roseman (YR) were applied to evaluate the solubility of sulfadiazine, and sulfamethazine in ethylene glycol + water mixtures. Methodology: reported experimental equilibrium solubilities and some fusion properties of these drugs were used for the calculations.Results: a good predictive character of EHSA (with mean deviations lower than 3.0%) were found by using regular polynomials in order two correlating the inter-action parameter W with the Hildebrand solubility parameter of solvent mixtures without drug ; however, the results obtained from YR model show relatively high deviations greater than 50%.
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