Evaluation of Biological Activity of Oil Crocodylus moreletii on Glucose levels Using a Diabetic Model

Abstract

There are some reports which show that omega-3 fatty acids extracted from either animals or plants can be used to reduce glucose levels in diabetic patients; however, the results are very confusing; perhaps this phenomenon is due to the different protocols used. Analyzing these data, this study aimed to evaluate the biological activity of the oil extracted from Crocodylus moreletii at a dose of 100, 200, and 300 µl/kg using metformin glibenclamide and sodium oleate as controls in a diabetic rat model. The results showed that oil Crocodylus moreletii lowered glucose levels in a dose-dependent manner than untreated diabetic rats. Furthermore, the effects produced by Crocodylus moreletii oil and sodium oleate on glucose concentration were very similar. However, the biological activity exerted by glibenclamide and metformin on glucose levels was different from to effect induced by Crocodylus moreletii oil and sodium oleate. In conclusion, the biological activity of Crocodylus moreletii oil is interesting and could be considered a therapeutic alternative for the treatment of diabetes.