The effect of ultrafiltration transmembrane permeation on the flow field in a surrogate system of an artificial kidney

Experimental Results Pub Date : 2021-03-30 DOI:10.1017/exp.2021.5

Matilde De Pascale, Mónica Faria, C. Boi, V. Semião, M. N. de Pinho

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引用次数: 5

Abstract

Abstract Renal Replacement Therapies generally associated to the Artificial Kidney (AK) are membrane-based treatments that assure the separation functions of the failing kidney in extracorporeal blood circulation. Their progress from conventional hemodialysis towards high-flux hemodialysis (HFHD) through the introduction of ultrafiltration membranes characterized by high convective permeation fluxes intensified the need of elucidating the effect of the membrane fluid removal rates on the increase of the potentially blood-traumatizing shear stresses developed adjacently to the membrane. The AK surrogate consisting of two-compartments separated by an ultrafiltration membrane is set to have water circulation in the upper chamber mimicking the blood flow rates and the membrane fluid removal rates typical of HFHD. Pressure drop mirrors the shear stresses quantification and the modification of the velocities profiles. The increase on pressure drop when comparing flows in slits with a permeable membrane and an impermeable wall is ca. 512% and 576% for $ \mathrm{CA}22/5\%{\mathrm{SiO}}_2 $ and $ \mathrm{CA}30/5\%{\mathrm{SiO}}_2 $ membranes, respectively.

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超滤跨膜渗透对人工肾脏替代系统流场的影响

肾脏替代疗法通常与人工肾(AK)相关，是基于膜的治疗，确保衰竭肾脏在体外血液循环中的分离功能。通过引入以高对流渗透通量为特征的超滤膜，他们从传统血液透析向高通量血液透析(HFHD)的发展，加强了阐明膜液去除率对膜附近形成的潜在血液创伤剪应力增加的影响的必要性。AK替代物由超滤膜分离的两个室组成，在上室设置水循环，模拟HFHD典型的血液流动速率和膜液去除速率。压降反映了剪切应力的量化和速度剖面的变化。$ \mathrm{ca}22/5\%{\mathrm{SiO}}_2 $和$ \mathrm{ca}30/5\%{\mathrm{SiO}}_2 $膜缝内流动的压降增幅分别为512%和576%。

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Experimental Results

CiteScore

1.50

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0.00%

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