Evaluation of Edible Oyster Mushroom (Pleurotus ostreatus) on Oxidative Stress and Neurological Cognitive Disorder in Streptozotocin-Diabetic Rats

Abstract

Pleurotus ostreatus is drawn into lime light for the treatment of Diabetes mellitus for the last few years, but now it is evidently proven for the recovery of the diabetes mellitus-induced memory impairments in streptozoticin induced diabetic rats. Oxidative stress, neurological disorders, cognitive and spatial learning associated to Diabetic-Alzheimer’s is irreversibly inhibited by P. ostreatus. The availability and cost effectively makes a stepping stone for the middle to low income people to rely on P. ostreatus rather than of costly medications for the treatment of neurological and cognitive disorders associated with Diabetes. The research was done to identify a potent free radical bioactive compound against cognitive impairment in streptozotocin –diabetic rats. Five weeks after diabetic induction, P. ostreatus extract was administered orally (2 mg/lt). The cognitive, cerebral and perceptive behaviour was examined with T Maze (Radial Arm Maze), Morris Water Maze (MWM), Novel object recognition task in wistar rats (male). Besides oxidative stress parameters like Lipid peroxidation (LPO), FRAP (Ferric reducing ability of plasma), antioxidant assay and Thiol assay to determine total Thiol group in the blood was carried out to determine the neurological disorders associated with brain. P. ostreatus showed significant improvements in Spatial and Cognitive disorders when compared to the diabetic and healthy control. Also the FRAP and thiol group in blood showed tremendous increase due to the P. ostreatus proving the effectiveness of Pleurotus extract on Cognitive impairment and Oxidative stress in Diabetic mellitus.