Review on preclinical and clinical trials of Indian herbal formulation against SARC COV-2

Abstract

Mutation of the SARS-CoV-2 spikes protein leads to the appearance of novel variants with modified form that appear to be more transmissible and can escape immunity generated by the vaccine. Continuous mutation in SARC COV and the emergence of more competent variants have sparked alarm for the alternative way to strengthen the immunity and fight corona sustainably. Natural products have been investigated in the last decades to develop novel candidates for drug research. Medicinal plants are considered helpful for preventing and treating several diseases and COVID-19 patients. Thus, this review presents the Indian medicinal plant and its promising active ingredients that exhibit inhibitory activity against SARS-CoV-2. The present paper also reviewed the AYUSH recommended formulations and their ingredients routinely used by the Indian population and covid positive patients.