Diabetes in Individuals with Tuberous Sclerosis Complex Treated with MTOR Inhibitors

Abstract

Tuberous sclerosis complex (TSC) is a genetic disorder that is manifested in multiple body systems. Diabetes mellitus is a disorder of carbohydrate metabolism characterized by impaired ability of the body to produce or respond to insulin and thereby maintain proper levels of glucose in the blood. mTOR inhibitors are a class of drugs that inhibit the mechanistic target of rapamycin (mTOR), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases (PIKKs)