CHOLESTASIS AND MITOCHONDRIAL DYSFUNCTION: A REVIEW

Abstract

Although liver diseases such as cholestasis are a significant clinical problem, the cellular mechanisms disturbed during these pathophysiological processes are still controversial. Progress along several lines of research have revealed several possible lines of action, pointing to new approaches to medical treatment. Impairment of mitochondrial function seems to be a central biochemical pathway of cell dysfunction during disease. Additionally, perturbation of other cellular functions could play a pivotal role in triggering these pathological events. Our review provides an overview of probable events involved in the cholestatic disease process.