Stability of Various Liposome Formulation Containing the Phytochemical-Peptide Derivatives

Abstract

: In this study, we investigated the stability of the liposome formulation containing the phytochemicals-peptide derivatives. Among liposomes prepared using lecithins or surfactant under various conditions, the most stable niosome was obtained by using sodium palmitoyl sarcosinate and macadamia intergrifolia seed oil. The stability of peptide-con-taining niosome (N9) was confirmed by the TEM images. The N9 was stable at 0 and 45 degrees by Turbiscan, and its particle size was 95.7 nm. The N9 showed zeta potential value of － 78.19 mV, and peptide-inclusion rate of 65.2% by BCA assay.