Perspectives on Microsampling in Bioanalysis: Opportunities and Challenges in the era of the COVID-19 pandemic-an Interview with Dr. James Rudge

Abstract

crosampling techniques? Around 2009 I became involved with microsampling for bioanalysis research when working with clients in the field, helping to set up novel bioanalytical assays specifically around sample preparation. One area which was emerging at the time was the use of DBS for PK studies. The advantage of this technique was that remote samples could be taken without the need of a phlebotomist. Furthermore, once dried, the samples were often stable under ambient conditions so they could be posted in the regular mail without the need for cold-chain shipping. These were advantages for companies running clinical trial research projects, especially when access to phlebotomy services and refrigeration was limited. I spoke to Dr. Neil Spooner, who was pioneering quantitative DBS work for the DMPK department at GSK, and he told me of the drawbacks of DBS filter paper cards. One drawback was of sample quality and the second was of quantitation. He told me that efforts were being made to improve Neoteryx, Torrance, CA 90501, USA.