Analytical techniques and methods for study of drug-lipid membrane interactions

IF 3.6 3区 化学 Q2 CHEMISTRY, ANALYTICAL Reviews in Analytical Chemistry Pub Date : 2017-11-30 DOI:10.1515/revac-2017-0012
Hewen Li, T. Zhao, Zhihua Sun
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引用次数: 19

Abstract

Abstract A better elucidation of molecular mechanisms underlying drug-membrane interaction is of great importance for drug research and development. To date, different biochemical and biophysical methods have been developed to study biological membranes at molecular level. This review focuses on the recent applications and achievements of modern analytical techniques in the study of drug interactions with lipid membranes, including chromatography, spectrometry, calorimetry, and acoustic sensing. The merits and limitations of these techniques were compared and critically discussed. Moreover, various types of biomimetic model membranes including liposomes, lipid monolayers, and supported lipid monolayers/bilayers were described. General mechanisms underlying drug-membrane interaction process were also briefly introduced.
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药物-脂质膜相互作用研究的分析技术与方法
摘要更好地阐明药物-膜相互作用的分子机制对药物研究和开发具有重要意义。迄今为止,不同的生物化学和生物物理方法已经发展到在分子水平上研究生物膜。本文综述了近年来现代分析技术在药物与脂质膜相互作用研究中的应用和成果,包括色谱法、光谱法、量热法和声传感等。对这些技术的优点和局限性进行了比较和批判性讨论。此外,还描述了各种类型的仿生模型膜,包括脂质体,脂质单层和支持脂质单层/双层。并简要介绍了药物-膜相互作用过程的一般机制。
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来源期刊
Reviews in Analytical Chemistry
Reviews in Analytical Chemistry 化学-分析化学
CiteScore
7.50
自引率
0.00%
发文量
15
审稿时长
>12 weeks
期刊介绍: Reviews in Analytical Chemistry publishes authoritative reviews by leading experts in the dynamic field of chemical analysis. The subjects can encompass all branches of modern analytical chemistry such as spectroscopy, chromatography, mass spectrometry, electrochemistry and trace analysis and their applications to areas such as environmental control, pharmaceutical industry, automation and other relevant areas. Review articles bring the expert up to date in a concise manner and provide researchers an overview of new techniques and methods.
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