Synthesis and Evaluation of Antipsychotic and Anticonvulsant Activity of Indol-5-YL and Benzoxazepin-4-YL Carbazoles

Abstract

Various1-(substituted indolylidenylchalconyl) carbazole(2a-2b), 1-[2-(5substituted indolyl)-1 ’ , 5 ’ -benzoxazepinyl]-carbazoles(3a-3b) and 1-[2 ’ -(5 ’’ -substituted indolyl)-3’-(2’’’-substitutedphenyl amino)-methyl-1’, 5 ’ -benzoxazepinyl]-carbazoles(4a-4n) have been synthesized according to scheme -1. These compounds were screened for antipsychotic and anticonvulsant activity as well as for acute toxicity. Compound 4dI.E. 1-[2 ’ (5 ’’ -methoxy indolyl)-3’-(2’’’,3’’’dichlorophenyl amino)-methyl-1’, 5 ’ -benzoxazepinyl]carbazoles showed most promising antipsyctotic and anticonvulsant activity with ALD50greaterthan 2000 mg/kg i.p. The structures of all the newly synthesized compounds were confirmed by elemental (C, H, N) and spectral (IR, 1 H-NMR and mass) analysis.