Greener Buchwald-Hartwig Reaction on Various Heterocycles Using Eucalyptol as Solvent

J. F. Campos, Sabine Berteina‐Raboin
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Abstract

We report here the use of eucalyptol as bio-based solvent for Buchwald-Hartwig reaction on various heterocycles. This solvent is interesting on the one hand because it is a non-toxic solvent and on the other hand that its use is a source of development for the consumption of waste from the paper industry that are leaves. These heterocycles containing oxygen, sulfur and nitrogen, which can present interesting therapeutic activities, were chosen as targets or as starting materials in this study. Our objective was to demonstrate that eucalyptol was a possible sustainable alternative to common solvents.
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以桉木醇为溶剂的各种杂环更绿的Buchwald-Hartwig反应
本文报道了桉树醇作为生物基溶剂在各种杂环上进行Buchwald-Hartwig反应。这种溶剂很有趣,一方面因为它是一种无毒的溶剂,另一方面,它的使用是发展的来源,利用造纸工业的废物,也就是叶子。这些含氧、硫和氮的杂环化合物具有有趣的治疗活性,本研究选择它们作为靶点或起始材料。我们的目标是证明桉树醇是一种可能的可持续替代普通溶剂。
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