Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.31
Anna Och, Agata Ćwikła, Karolina Orzechowska, A. Cwener
Introduction and aim. The assessment of the antioxidant activity of plant extracts is an important research direction in the search for new chemopreventive substances. The aim of this study was to demonstrate the antioxidant potential of the methanol extract of Berberis jaeschkeana C. K. Schneid fruit. Material and methods. Spectrophotometric tests were carried out: testing of the total content of polyphenols (TPC) in extracts, testing of the total content of flavonoids (TFC) in extracts. Antiradical activity was determined using the improved ABTS+• decolorization test with modifications. Results. TPC extracts was determined at the level of 43.52±2.37 mg/g, while TFC extracts was determined at the level 6.08±0.48 mg/g. The ABTS activity test showed 31.15 mg/g expressed as mg Trolox per g of dry extract. Conclusion. It was assessed that the methanolic extract of the fruit of Berberis jaeschkeana C. K. Schneid. has an antioxidant properties, what makes it a potential chemopreventive agent in civilizational diseases.
引言和目的。评估植物提取物的抗氧化活性是寻找新的化学预防物质的一个重要研究方向。本研究旨在证明小檗（Berberis jaeschkeana C. K. Schneid）果实甲醇提取物的抗氧化潜力。材料和方法。进行了分光光度测试：测试提取物中多酚的总含量（TPC），测试提取物中黄酮类化合物的总含量（TFC）。使用改进的 ABTS+- 脱色试验测定抗自由基活性。结果TPC 提取物的含量为 43.52±2.37 mg/g，TFC 提取物的含量为 6.08±0.48 mg/g。ABTS 活性测试显示为 31.15 mg/g，以每克干提取物含 mg Trolox 表示。结论经评估，红叶小檗果实的甲醇提取物具有抗氧化特性，使其成为潜在的文明病化学预防剂。
{"title":"Evaluation of the antioxidant activity of Berberis jaeschkeana C. K. Schneid. fruits using the ABTS assay","authors":"Anna Och, Agata Ćwikła, Karolina Orzechowska, A. Cwener","doi":"10.15584/ejcem.2023.4.31","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.31","url":null,"abstract":"Introduction and aim. The assessment of the antioxidant activity of plant extracts is an important research direction in the search for new chemopreventive substances. The aim of this study was to demonstrate the antioxidant potential of the methanol extract of Berberis jaeschkeana C. K. Schneid fruit. Material and methods. Spectrophotometric tests were carried out: testing of the total content of polyphenols (TPC) in extracts, testing of the total content of flavonoids (TFC) in extracts. Antiradical activity was determined using the improved ABTS+• decolorization test with modifications. Results. TPC extracts was determined at the level of 43.52±2.37 mg/g, while TFC extracts was determined at the level 6.08±0.48 mg/g. The ABTS activity test showed 31.15 mg/g expressed as mg Trolox per g of dry extract. Conclusion. It was assessed that the methanolic extract of the fruit of Berberis jaeschkeana C. K. Schneid. has an antioxidant properties, what makes it a potential chemopreventive agent in civilizational diseases.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.15
Vijay Kumar, ID Ratnadeep Biswas, Vishnu S. Ojha, Kishore Kaushal
Introduction and aim. Any hospital’s outpatient department (OPD) is regarded as the storefront of the facility, and patient satisfaction is an important measure of healthcare quality. Hence, this cross-sectional study was conducted in different OPDs at a tertiary care center. Material and methods. Two hundred patients were recruited, and structured personal interviews were conducted with questions based on the Patient Satisfaction Questionnaire Short Form (PSQ-18). T-tests and analysis of variance (ANOVA) were used to compare satisfaction scores between variables. Results. Upon analysis, 86% of the patients rated their overall experience as either ‘very good’ or ‘good’. Interpersonal manners (mean score±SD; 4.60±0.55), communication (4.39±0.66), general satisfaction (4.03±0.79), and technical qualities (3.86±0.57) were the domains in which the patients were most satisfied, while time spent with the doctor (3.77±0.89), accessibility and convenience (3.77±0.67), and financial aspects (3.37±0.83) were the areas that lagged. Conclusion. Satisfaction scores were found to vary significantly with gender, age, waiting times, and the number of visits per day. Regular patient satisfaction surveys should be conducted in all hospitals for devising interventions to provide patients with the best possible care.
导言和目的。任何医院的门诊部（OPD）都被视为医院的门面，患者满意度是衡量医疗质量的重要标准。因此，本横断面研究在一家三级医疗中心的不同门诊部进行。材料和方法招募了 200 名患者，并根据患者满意度问卷简表（PSQ-18）的问题进行了结构化个人访谈。采用 T 检验和方差分析（ANOVA）比较不同变量的满意度得分。结果。经分析，86% 的患者将其总体体验评为 "非常好 "或 "好"。患者最满意的领域包括人际交往（平均分±SD；4.60±0.55）、沟通（4.39±0.66）、总体满意度（4.03±0.79）和技术质量（3.86±0.57），而与医生共处的时间（3.77±0.89）、可及性和便利性（3.77±0.67）以及经济方面（3.37±0.83）则相对落后。结论研究发现，满意度得分随性别、年龄、候诊时间和每天就诊次数的不同而有显著差异。所有医院都应定期进行患者满意度调查，以便制定干预措施，为患者提供尽可能好的护理服务。
{"title":"Satisfaction levels of patients attending the outpatient department of a tertiary care center of India","authors":"Vijay Kumar, ID Ratnadeep Biswas, Vishnu S. Ojha, Kishore Kaushal","doi":"10.15584/ejcem.2023.4.15","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.15","url":null,"abstract":"Introduction and aim. Any hospital’s outpatient department (OPD) is regarded as the storefront of the facility, and patient satisfaction is an important measure of healthcare quality. Hence, this cross-sectional study was conducted in different OPDs at a tertiary care center. Material and methods. Two hundred patients were recruited, and structured personal interviews were conducted with questions based on the Patient Satisfaction Questionnaire Short Form (PSQ-18). T-tests and analysis of variance (ANOVA) were used to compare satisfaction scores between variables. Results. Upon analysis, 86% of the patients rated their overall experience as either ‘very good’ or ‘good’. Interpersonal manners (mean score±SD; 4.60±0.55), communication (4.39±0.66), general satisfaction (4.03±0.79), and technical qualities (3.86±0.57) were the domains in which the patients were most satisfied, while time spent with the doctor (3.77±0.89), accessibility and convenience (3.77±0.67), and financial aspects (3.37±0.83) were the areas that lagged. Conclusion. Satisfaction scores were found to vary significantly with gender, age, waiting times, and the number of visits per day. Regular patient satisfaction surveys should be conducted in all hospitals for devising interventions to provide patients with the best possible care.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139140967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.16
A. Nikulina
Introduction and aim. Dysfunction of the glucagon-like peptide 1 (GLP-1)/GLP-1 receptor (GLP-1R) axis promotes obesity and metabolic disorders. The aim was to study the associations of the single nucleotide variants (SNV) GLP1R gene with proinflammatory cytokines and metabolic disorders in children with various obesity phenotypes. Material and methods. 252 children with obesity aged 6-18 years were examined. The first group (n=152) was represented by children with metabolically unhealthy obesity (MUO). The second group (n=100) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 52 children. Results. An association with the development of obesity was noted for T alleles rs61754624 (t=3.33) and rs10305457 (t=2.06); with MUO – for C alleles rs1042044 (t=2.23), rs1126476 (t=2.63), rs2235868 (t=2.82); T alleles rs61754624 (t=3.33), rs10305457 (t=2.06) GLP1R, p<0.05. In the MHO group, a correlation was found with the levels of pro-inflammatory markers IL-1β, IL-6 in the presence of the GA genotype SNV rs3765468; with hyperglycemia - GA genotype SNV rs6923761, CC genotype SNV rs1042044, AA rs6918287; hyperinsulinemia - GA genotype SNV rs3765468, GG rs10305421; triglyceridemia - AA rs6918287 of GLP1R. Conclusion. SNV rs1042044, rs3765468, rs6923761, s6918287, and rs rs10305421 GLP1R are associated with the development of MUO in individuals with MHO.
{"title":"Genetic variants of the glucagon-like receptor-1 in obesity","authors":"A. Nikulina","doi":"10.15584/ejcem.2023.4.16","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.16","url":null,"abstract":"Introduction and aim. Dysfunction of the glucagon-like peptide 1 (GLP-1)/GLP-1 receptor (GLP-1R) axis promotes obesity and metabolic disorders. The aim was to study the associations of the single nucleotide variants (SNV) GLP1R gene with proinflammatory cytokines and metabolic disorders in children with various obesity phenotypes. Material and methods. 252 children with obesity aged 6-18 years were examined. The first group (n=152) was represented by children with metabolically unhealthy obesity (MUO). The second group (n=100) consolidated of children with metabolically healthy obesity (MHO). Whole genome sequencing (CeGat, Germany) was performed in 52 children. Results. An association with the development of obesity was noted for T alleles rs61754624 (t=3.33) and rs10305457 (t=2.06); with MUO – for C alleles rs1042044 (t=2.23), rs1126476 (t=2.63), rs2235868 (t=2.82); T alleles rs61754624 (t=3.33), rs10305457 (t=2.06) GLP1R, p<0.05. In the MHO group, a correlation was found with the levels of pro-inflammatory markers IL-1β, IL-6 in the presence of the GA genotype SNV rs3765468; with hyperglycemia - GA genotype SNV rs6923761, CC genotype SNV rs1042044, AA rs6918287; hyperinsulinemia - GA genotype SNV rs3765468, GG rs10305421; triglyceridemia - AA rs6918287 of GLP1R. Conclusion. SNV rs1042044, rs3765468, rs6923761, s6918287, and rs rs10305421 GLP1R are associated with the development of MUO in individuals with MHO.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139138011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.30
Kotha Vamshikrishnapatel, Vijay Kumar, Ratnadeep Biswas, Vishnu S. Ojha, A. Hegde
Introduction and aim. Fahr’s disease is a rare neurological disorder characterized by bilateral basal ganglia calcifications. The aim of this report is to highlight a case of Fahr’s disease with atypical features such as neck rigidity and peripheral nerve involvement. Description of the case. Here, we present the case of a South Asian patient with secondary Fahr’s disease whose clinical presentation mimicked that of meningoencephalitis. The patient had neurological and neuropsychiatric symptoms along with abnormal body movements. She also had restricted neck mobility. Computed tomography of the head revealed bilateral dense calcifications in the basal ganglia suggestive of Fahr’s syndrome. Investigations revealed severe hypocalcemia, hyperphosphatemia, and low parathyroid hormone levels, which led to the identification of hypoparathyroidism as the underlying cause. The presence of pre-existing epilepsy and neck rigidity made the diagnosis difficult. The relatively rapid development of symptoms along with the presence of peripheral nerve involvement made this case even more unique. Calcium levels were corrected, and there was a marked symptomatic improvement. Conclusion. Neck rigidity and restricted neck mobility may be present in cases of Fahr’s syndrome due to calcifications of the nuchal ligament or other spinal ligaments and thus must be differentiated from meningoencephalitis. Although the symptoms of Fahr’s syndrome are generally limited to the central nervous system, there may be involvement of the peripheral nerves as well.
{"title":"Secondary Fahr’s syndrome mimicking meningoencephalitis","authors":"Kotha Vamshikrishnapatel, Vijay Kumar, Ratnadeep Biswas, Vishnu S. Ojha, A. Hegde","doi":"10.15584/ejcem.2023.4.30","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.30","url":null,"abstract":"Introduction and aim. Fahr’s disease is a rare neurological disorder characterized by bilateral basal ganglia calcifications. The aim of this report is to highlight a case of Fahr’s disease with atypical features such as neck rigidity and peripheral nerve involvement. Description of the case. Here, we present the case of a South Asian patient with secondary Fahr’s disease whose clinical presentation mimicked that of meningoencephalitis. The patient had neurological and neuropsychiatric symptoms along with abnormal body movements. She also had restricted neck mobility. Computed tomography of the head revealed bilateral dense calcifications in the basal ganglia suggestive of Fahr’s syndrome. Investigations revealed severe hypocalcemia, hyperphosphatemia, and low parathyroid hormone levels, which led to the identification of hypoparathyroidism as the underlying cause. The presence of pre-existing epilepsy and neck rigidity made the diagnosis difficult. The relatively rapid development of symptoms along with the presence of peripheral nerve involvement made this case even more unique. Calcium levels were corrected, and there was a marked symptomatic improvement. Conclusion. Neck rigidity and restricted neck mobility may be present in cases of Fahr’s syndrome due to calcifications of the nuchal ligament or other spinal ligaments and thus must be differentiated from meningoencephalitis. Although the symptoms of Fahr’s syndrome are generally limited to the central nervous system, there may be involvement of the peripheral nerves as well.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction and aim. Defects in the epidermal barrier, changes in sebum secretion and its composition, Malassezia spp. overgrowth, endocrine, immune, and neurological disorders are the main pathogenesis items of seborrheic dermatitis (SD). “The opioid system of the skin” was considered a new target in the diagnosis and treatment of SD. The study aimed to determine beta-endorphin (BE) levels in adult patients with seborrheic dermatitis and correlate them with the severity of symptoms and itching. Material and methods. 26 healthy and 62 SD people were examined. SEDASI scale were used to estimate the severity of symptoms and intensity of itching. The determination of the beta-endorphin level was carried out by the ELISA method with the test system Human BE NBP2 (78774 Novus Biologicals). Results. BE in the SD group was higher compared to the control group (35.5 pg/mL, 22. pg/mL, p<0.001). The level of BE in seborrheic patients did not depend on age and sex but was rising with severity of symptoms. Positive correlations were found between the level of BE and the SEDASI was 0.42 (p<.001), between the level of BE and itching was 0.332 (p=0.009). Conclusion. SD patients have an increased level of BE that positively correlates with itching and disease severity.
导言和目的。表皮屏障缺陷、皮脂分泌及其成分变化、马拉色菌过度生长、内分泌、免疫和神经紊乱是脂溢性皮炎（SD）的主要发病机制。"皮肤的阿片系统 "被认为是诊断和治疗脂溢性皮炎的新目标。本研究旨在确定成年脂溢性皮炎患者体内的β-内啡肽（BE）水平，并将其与症状和瘙痒的严重程度相关联。材料和方法对 26 名健康人和 62 名脂溢性皮炎患者进行了研究。采用 SEDASI 量表评估症状严重程度和瘙痒强度。β-内啡肽水平的测定采用 ELISA 法，检测系统为人 BE NBP2（78774 Novus Biologicals）。结果与对照组相比，SD 组的 BE 含量更高（35.5 pg/mL，22. pg/mL，p<0.001）。脂溢性皮炎患者的 BE 水平与年龄和性别无关，但随着症状的严重程度而上升。BE 水平与 SEDASI 之间的正相关为 0.42（p<.001），BE 水平与瘙痒之间的正相关为 0.332（p=0.009）。结论SD患者的BE水平升高与瘙痒和疾病严重程度呈正相关。
{"title":"Plasma level of beta endorphin in seborrheic dermatitis patients","authors":"V. Vysochanska","doi":"10.15584/ejcem.2023.4.3","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.3","url":null,"abstract":"Introduction and aim. Defects in the epidermal barrier, changes in sebum secretion and its composition, Malassezia spp. overgrowth, endocrine, immune, and neurological disorders are the main pathogenesis items of seborrheic dermatitis (SD). “The opioid system of the skin” was considered a new target in the diagnosis and treatment of SD. The study aimed to determine beta-endorphin (BE) levels in adult patients with seborrheic dermatitis and correlate them with the severity of symptoms and itching. Material and methods. 26 healthy and 62 SD people were examined. SEDASI scale were used to estimate the severity of symptoms and intensity of itching. The determination of the beta-endorphin level was carried out by the ELISA method with the test system Human BE NBP2 (78774 Novus Biologicals). Results. BE in the SD group was higher compared to the control group (35.5 pg/mL, 22. pg/mL, p<0.001). The level of BE in seborrheic patients did not depend on age and sex but was rising with severity of symptoms. Positive correlations were found between the level of BE and the SEDASI was 0.42 (p<.001), between the level of BE and itching was 0.332 (p=0.009). Conclusion. SD patients have an increased level of BE that positively correlates with itching and disease severity.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction and aim. Over the past decades, the hypotheses that ascorbic acid (AA) can play a role as an anti-neoplastic therapy have generated many conflicting reports. Despite the controversies, mounting evidence has shown that AA has the potential to play a role as an anti-neoplastic agent. Recent studies have unraveled its pharmacokinetics and various mechanism of action on cancer cells. This has spawned different preclinical studies with reports of good activities against various cancers. Material and methods. A review of the literature regarding ascorbic acid in the management of cancer was performed using the PubMed database. The research was limited to abstracts and available full-text articles. Analysis of the literature. Clinical trials have also demonstrated its safety and tolerability across different dosages. AA has been noted as a multitargeting agent that acts as a pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator. AA has also been shown act synergistically with standard chemotherapy regimens in different cancers. Despite its potentials, phase III clinical trials are seriously lacking. The recent phase III VITALITY study shows that AA may play a role as an adjunct targeted therapy for ras-mutated cancers. Therefore, there is need to for more standardized clinical trials to help identify cancer subtypes and AA combination regimens that can show the most benefits. In this review, the pleiotropic mechanism of action of AA was explored as well as various preclinical and clinical studies in cancer therapy. In addition, recommendations were also made for effective strategies towards an AA and standard cancer regimens in treatment as well as future directions. Ascorbic acid has been shown to induce cell death in various cancer types through different mechanisms of action. Several clinical trials and case reports have shown its efficacy in combination chemotherapy, and the pharmacological route of action can be either intravenous or oral. However, it can impair the actions of some drugs when given in combination. Also, dosage should be determined for maximal pharmacologic action. Conclusion. Ascorbic acid has the potential to provide safe and cost-effective antineoplastic treatment option especially in combination therapy. Its potential needs to be further investigated through clinical trials.
引言和目的。在过去的几十年里，关于抗坏血酸（AA）可作为抗肿瘤疗法发挥作用的假设产生了许多相互矛盾的报道。尽管存在争议，但越来越多的证据表明，抗坏血酸具有作为抗肿瘤药物发挥作用的潜力。最近的研究揭示了 AA 的药代动力学和对癌细胞的各种作用机制。这催生了不同的临床前研究，有报告称 AA 对各种癌症具有良好的活性。材料和方法。使用 PubMed 数据库对有关抗坏血酸治疗癌症的文献进行了综述。研究仅限于摘要和可用的全文文章。文献分析。临床试验也证明了不同剂量抗坏血酸的安全性和耐受性。人们注意到 AA 是一种多靶点制剂，可作为促氧化细胞毒制剂、抗癌表观遗传调节剂和免疫调节剂。在不同的癌症中，AA 还能与标准化疗方案产生协同作用。尽管 AA 潜力巨大，但目前仍严重缺乏 III 期临床试验。最近的 VITALITY III 期研究表明，AA 可作为一种辅助靶向疗法用于治疗 ras 基因突变的癌症。因此，有必要进行更多标准化临床试验，以帮助确定癌症亚型和能产生最大疗效的 AA 组合方案。在这篇综述中，探讨了 AA 的多效应作用机制以及癌症治疗中的各种临床前和临床研究。此外，还就 AA 和标准癌症治疗方案的有效策略以及未来发展方向提出了建议。研究表明，抗坏血酸可通过不同的作用机制诱导各种癌症类型的细胞死亡。一些临床试验和病例报告显示了其在联合化疗中的疗效，其药理作用途径可以是静脉注射或口服。不过，联合用药时可能会影响某些药物的作用。此外，应确定剂量以发挥最大药理作用。结论抗坏血酸具有提供安全、经济的抗肿瘤治疗选择的潜力，尤其是在联合治疗中。其潜力需要通过临床试验进一步研究。
{"title":"Ascorbic acid in cancer management – time for a second look","authors":"Izuegbuna Ogochukwu","doi":"10.15584/ejcem.2023.4.7","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.7","url":null,"abstract":"Introduction and aim. Over the past decades, the hypotheses that ascorbic acid (AA) can play a role as an anti-neoplastic therapy have generated many conflicting reports. Despite the controversies, mounting evidence has shown that AA has the potential to play a role as an anti-neoplastic agent. Recent studies have unraveled its pharmacokinetics and various mechanism of action on cancer cells. This has spawned different preclinical studies with reports of good activities against various cancers. Material and methods. A review of the literature regarding ascorbic acid in the management of cancer was performed using the PubMed database. The research was limited to abstracts and available full-text articles. Analysis of the literature. Clinical trials have also demonstrated its safety and tolerability across different dosages. AA has been noted as a multitargeting agent that acts as a pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator. AA has also been shown act synergistically with standard chemotherapy regimens in different cancers. Despite its potentials, phase III clinical trials are seriously lacking. The recent phase III VITALITY study shows that AA may play a role as an adjunct targeted therapy for ras-mutated cancers. Therefore, there is need to for more standardized clinical trials to help identify cancer subtypes and AA combination regimens that can show the most benefits. In this review, the pleiotropic mechanism of action of AA was explored as well as various preclinical and clinical studies in cancer therapy. In addition, recommendations were also made for effective strategies towards an AA and standard cancer regimens in treatment as well as future directions. Ascorbic acid has been shown to induce cell death in various cancer types through different mechanisms of action. Several clinical trials and case reports have shown its efficacy in combination chemotherapy, and the pharmacological route of action can be either intravenous or oral. However, it can impair the actions of some drugs when given in combination. Also, dosage should be determined for maximal pharmacologic action. Conclusion. Ascorbic acid has the potential to provide safe and cost-effective antineoplastic treatment option especially in combination therapy. Its potential needs to be further investigated through clinical trials.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139139814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.24
Hande Yardımcı Kurtoğlu, Sevecen Çelik İnce
Introduction and aim. Individuals with severe mental illness experience more physical health problems than the general population and their life expectancy may be shorter. Therefore, the physical care provided to these patients is very important.This study aims to examine the attitudes, practices, and training needs of nurses working in psychiatry clinics towards physical health care of individuals with severe mental illness. Material and methods. This descriptive, cross-sectional study collected data from 139 nurses in psychiatry clinics using the Personal Information Form and Physical Health Attitude Scale. Results. This study found that nurses often provide physical healthcare as part of their routine care for individuals with severe mental illness. However, the study also revealed that nurses require additional education to better provide this type of care. Despite this, the nurses generally displayed a positive attitude towards physical health. The average total score on the physical health attitude scale was 80.33±10.14. Conclusion. The study concluded that nurses have a positive attitude towards physical health in general. The role of nurses working in psychiatry clinics is crucial in evaluating and caring for physical health of individuals with severe mental illness, as it is an important aspect of holistic nursing care. It is necessary to make nurses aware of their shortcomings in providing physical health care and support them in improving in this area.
{"title":"Determination of attitudes and practices of nurses working in the psychiatry clinic towards physical health care of individuals with severe mental illness","authors":"Hande Yardımcı Kurtoğlu, Sevecen Çelik İnce","doi":"10.15584/ejcem.2023.4.24","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.24","url":null,"abstract":"Introduction and aim. Individuals with severe mental illness experience more physical health problems than the general population and their life expectancy may be shorter. Therefore, the physical care provided to these patients is very important.This study aims to examine the attitudes, practices, and training needs of nurses working in psychiatry clinics towards physical health care of individuals with severe mental illness. Material and methods. This descriptive, cross-sectional study collected data from 139 nurses in psychiatry clinics using the Personal Information Form and Physical Health Attitude Scale. Results. This study found that nurses often provide physical healthcare as part of their routine care for individuals with severe mental illness. However, the study also revealed that nurses require additional education to better provide this type of care. Despite this, the nurses generally displayed a positive attitude towards physical health. The average total score on the physical health attitude scale was 80.33±10.14. Conclusion. The study concluded that nurses have a positive attitude towards physical health in general. The role of nurses working in psychiatry clinics is crucial in evaluating and caring for physical health of individuals with severe mental illness, as it is an important aspect of holistic nursing care. It is necessary to make nurses aware of their shortcomings in providing physical health care and support them in improving in this area.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139141028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.10
Igor Grygus, A. Nogas
Introduction and aim. Rheumatoid arthritis is a chronic progressive systemic disease of the connective tissue affecting the joints, mainly small, of the erosive-destructive polyarthritis type, and frequent systemic inflammatory damage to internal organs. The purpose of the research is to evaluate the effectiveness of physical therapy on the muscles of upper limbs in patients with rheumatoid arthritis by the dynamics of muscle strength and strength index. Material and methods. To determine the strength of the muscles of the affected upper limbs were used dynamometry, calculated strength index as a percentage to assess the functional ability of the affected limb. All patients were divided into control (n=92) and main (n=96) groups, taking into account the functional insufficiency of the joints. Results. After 6 months of physical therapy, muscle strength indicators in the main group of patients with 1st degree of functional joints insufficiency (FJI) in the affected right limb increased by 3.1 kg, in the left by 3 kg; with 2nd degree FJI – in the right limb by 4.2 kg, in the left – by 3.7 kg, significantly exceeded the same indicators in patients of the control group (р<0.05). Similarly, there was an increase in the strength index in the patients of the main group. Conclusion. Physical therapy technology has been developed and implemented effectively influenced the increase in muscle strength and strength index of affected upper limbs of the main group of patients with rheumatoid arthritis.
{"title":"The effect of a physical therapy programme on the condition of upper limb muscles in patients with rheumatoid arthritis","authors":"Igor Grygus, A. Nogas","doi":"10.15584/ejcem.2023.4.10","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.10","url":null,"abstract":"Introduction and aim. Rheumatoid arthritis is a chronic progressive systemic disease of the connective tissue affecting the joints, mainly small, of the erosive-destructive polyarthritis type, and frequent systemic inflammatory damage to internal organs. The purpose of the research is to evaluate the effectiveness of physical therapy on the muscles of upper limbs in patients with rheumatoid arthritis by the dynamics of muscle strength and strength index. Material and methods. To determine the strength of the muscles of the affected upper limbs were used dynamometry, calculated strength index as a percentage to assess the functional ability of the affected limb. All patients were divided into control (n=92) and main (n=96) groups, taking into account the functional insufficiency of the joints. Results. After 6 months of physical therapy, muscle strength indicators in the main group of patients with 1st degree of functional joints insufficiency (FJI) in the affected right limb increased by 3.1 kg, in the left by 3 kg; with 2nd degree FJI – in the right limb by 4.2 kg, in the left – by 3.7 kg, significantly exceeded the same indicators in patients of the control group (р<0.05). Similarly, there was an increase in the strength index in the patients of the main group. Conclusion. Physical therapy technology has been developed and implemented effectively influenced the increase in muscle strength and strength index of affected upper limbs of the main group of patients with rheumatoid arthritis.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139137487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-12-30DOI: 10.15584/ejcem.2023.4.25
I. Dolu, Feyza Demir Bozkurt
Introduction and aim. Health promotion is one of the common elements of sustainable development goals. The aim of this study was to identify the impact of “Healthy Life and Environment” course on nursing student’s awareness of sustainable development and healthy life, and health-promoting lifestyle behaviours. Material and methods. A pre-, and post-test control group quasi-experimental research design was used. One nursing department located in Nortwest Blacksea region, Turkey. A total of 160 nursing students pursuing bachelor nursing programs. Students from first and second years who enrolled in the “Healthy Life and Environment” course assigned to intervention group, those who did not attend the course assigned to control group. Results. Female students had higher level of HPLP II and SDA than male. SDA had a weak correlation with HLA and a very week correlation with HPLP II at baseline. Intervention group had an improvement of .03 points in HPLP II, no change in HLA, and a slight improvement of .01 points in SDA, however these differences were not statistically important. Conclusion. The results of our study highlighted that nursing curricula need to be modified to incorporate sustainable development methodology using student-centered learning.
导言和目的。促进健康是可持续发展目标的共同要素之一。本研究旨在确定 "健康生活与环境 "课程对护理专业学生的可持续发展和健康生活意识以及促进健康的生活方式行为的影响。材料和方法采用前测和后测对照组的准实验研究设计。研究对象为土耳其西北黑海地区的一个护理系。共有 160 名护理专业本科生。选修 "健康生活与环境 "课程的一、二年级学生为干预组，未选修该课程的学生为对照组。结果显示女生的 HPLP II 和 SDA 水平高于男生。SDA 与 HLA 的相关性较弱，而与 HPLP II 的相关性很低。干预组的 HPLP II 提高了 0.03 分，HLA 没有变化，SDA 略微提高了 0.01 分，但这些差异在统计学上并不重要。结论我们的研究结果表明，需要对护理课程进行修改，采用以学生为中心的学习方法，融入可持续发展的理念。
{"title":"Nursing students’ awareness of health-promoting lifestyle profile and sustainable development goals – a quasi-experimental study","authors":"I. Dolu, Feyza Demir Bozkurt","doi":"10.15584/ejcem.2023.4.25","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.25","url":null,"abstract":"Introduction and aim. Health promotion is one of the common elements of sustainable development goals. The aim of this study was to identify the impact of “Healthy Life and Environment” course on nursing student’s awareness of sustainable development and healthy life, and health-promoting lifestyle behaviours. Material and methods. A pre-, and post-test control group quasi-experimental research design was used. One nursing department located in Nortwest Blacksea region, Turkey. A total of 160 nursing students pursuing bachelor nursing programs. Students from first and second years who enrolled in the “Healthy Life and Environment” course assigned to intervention group, those who did not attend the course assigned to control group. Results. Female students had higher level of HPLP II and SDA than male. SDA had a weak correlation with HLA and a very week correlation with HPLP II at baseline. Intervention group had an improvement of .03 points in HPLP II, no change in HLA, and a slight improvement of .01 points in SDA, however these differences were not statistically important. Conclusion. The results of our study highlighted that nursing curricula need to be modified to incorporate sustainable development methodology using student-centered learning.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139138937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Makkar, Sandeep Gupta, Aiana Singh, Smriti Rohilla
Introduction and aim. One of the imperative reasons for endodontic failure is an extra or missed root and root canals. Permanent mandibular lateral incisors generally present as monoradicular tooth with one or two canals, but aberrancies in the form of extra root are also rarely seen. There is insufficiency in the literary work regarding the presence of an extra root in permanent mandibular lateral incisor. We hereby report two illustrious cases of biradicular permanent mandibular lateral incisors and their endodontic management and brief review regarding the case reports published so far regarding the existence of an extra root in permanent mandibular lateral incisor in the literature. Also, we intend to apprise the scientific documentation with the aforementioned. Description of the cases. Case 1. A twenty-two-year-old male patient of Indian origin was referred to endodontic clinic for intentional root canal therapy. Pre-operative radiograph revealed 32 exhibited aberrancy in the form of an extra root, with normal periodontal structures and bone architecture. Case 2. A sixty-two-year-old male patient came to the Department of Conservative Dentistry and Endodontics with the chief complaint of pain in the lower anterior tooth region. Radiographic examination revealed root caries on the mesial side and two roots with two canals with bifurcation at the level of middle third of root. Conclusion. Clinicians should be well prepared in advance for management of any anatomical aberrancy in their clinical practice by having a scrupulous knowledge of root canal system.
{"title":"Demystifying the intricacies – a rare report of two cases of biradicular permanent mandibular lateral incisor and their endodontic management","authors":"S. Makkar, Sandeep Gupta, Aiana Singh, Smriti Rohilla","doi":"10.15584/ejcem.2023.4.9","DOIUrl":"https://doi.org/10.15584/ejcem.2023.4.9","url":null,"abstract":"Introduction and aim. One of the imperative reasons for endodontic failure is an extra or missed root and root canals. Permanent mandibular lateral incisors generally present as monoradicular tooth with one or two canals, but aberrancies in the form of extra root are also rarely seen. There is insufficiency in the literary work regarding the presence of an extra root in permanent mandibular lateral incisor. We hereby report two illustrious cases of biradicular permanent mandibular lateral incisors and their endodontic management and brief review regarding the case reports published so far regarding the existence of an extra root in permanent mandibular lateral incisor in the literature. Also, we intend to apprise the scientific documentation with the aforementioned. Description of the cases. Case 1. A twenty-two-year-old male patient of Indian origin was referred to endodontic clinic for intentional root canal therapy. Pre-operative radiograph revealed 32 exhibited aberrancy in the form of an extra root, with normal periodontal structures and bone architecture. Case 2. A sixty-two-year-old male patient came to the Department of Conservative Dentistry and Endodontics with the chief complaint of pain in the lower anterior tooth region. Radiographic examination revealed root caries on the mesial side and two roots with two canals with bifurcation at the level of middle third of root. Conclusion. Clinicians should be well prepared in advance for management of any anatomical aberrancy in their clinical practice by having a scrupulous knowledge of root canal system.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139137704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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