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Reading and the Art of Librarianship最新文献

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Carnegie Libraries 卡内基图书馆
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-73
John B. Nicholson
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引用次数: 0
Fairy Tales 童话故事
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-38
John B. Nicholson
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引用次数: 0
Book Shops 书店
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-56
John B. Nicholson
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引用次数: 0
A Matter of Taste 品味问题
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-5
J. Lichter
......................................................................................................................2 DEDICATION ......................................................................................................................3 ACKNOWLEDGMENTS ....................................................................................................4 LIST OF FIGURES ..............................................................................................................6
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引用次数: 0
Austin Tappan Wright 奥斯汀·塔潘·赖特
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-46
John B. Nicholson
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引用次数: 0
Treasure Hunt 寻宝游戏
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-53
John B. Nicholson
Learning to navigate towards a goal location involves both spatial memory and reward (goal) encoding, and hippocampal pyramidal cells play roles in both. How goal location is encoded is not well understood, but here, Gauthier and Tank identify a subpopulation of cells in hippocampal CA1 and subiculum that are dedicated to this role. The authors designed a virtual reality task in which head-fixed mice ran on a linear track while a virtual environment was projected on a surrounding screen. This set-up allowed water-restricted mice to be trained to ‘traverse’ this virtual environment towards a particular location where they would receive a water reward (the goal); neural activity in CA1 and subiculum was monitored simultaneously using two-photon imaging. As expected, in both subiculum and CA1 the authors found numerous cells that respond differently depending on position on the track, with a greater density of place fields occurring near the reward location. Although the place fields of most cells remained the same when the location of the reward was changed, a few cells tracked the new reward location. The authors determined that these cells constituted a small, discrete population of cells separate from place cells, which they termed reward-associated cells (RACs). RACs consistently produced reward-associated responses across different virtual environments and accounted for the increased density of cell responses near the reward location. Within this population, some fired before the reward (reward-predictive cells, RPCs), and when the reward location and/or environment was changed, the sequence of activation and timing of RPCs remained highly consistent, suggesting that these cells are highly specialized for encoding reward location. RPC firing in both CA1 and subiculum coincided with anticipatory behaviours, such as slowing down on approach to the reward location and anticipatory licking. The authors found that RPC firing at the current reward location was approximately five times greater than at a previously-trained reward location, whereas anticipatory behaviours were similar at both locations, suggesting that RPCs do not directly encode behaviour. Overall, these data reveal a population of cells in both subiculum and CA1 that encode the location of a reward with high consistency, even when the location or environment containing the reward changes.
学习导航到目标位置涉及空间记忆和奖励(目标)编码,海马体锥体细胞在两者中都起作用。目标定位是如何编码的还不是很清楚,但在这里,Gauthier和Tank确定了海马CA1和下托的一个细胞亚群,专门负责这个角色。作者设计了一个虚拟现实任务,在这个任务中,头部固定的老鼠在线性轨道上奔跑,而虚拟环境投射在周围的屏幕上。这种设置允许限制水的老鼠经过训练,“穿越”这个虚拟环境,到达一个特定的位置,在那里它们将获得水奖励(目标);双光子成像同时监测CA1和耻骨下的神经活动。正如预期的那样,在耻骨下和CA1中,作者发现许多细胞根据轨道上的位置做出不同的反应,在奖励位置附近出现更大的位置场密度。虽然当奖赏的位置改变时,大多数细胞的位置域保持不变,但少数细胞跟踪新的奖赏位置。作者确定,这些细胞构成了一个小的、离散的细胞群,与位置细胞分开,他们称之为奖励相关细胞(RACs)。rac在不同的虚拟环境中始终产生与奖励相关的反应,并解释了奖励位置附近细胞反应密度的增加。在这个群体中,一些细胞在奖励出现之前被激活(奖励预测细胞,RPCs),当奖励位置和/或环境发生变化时,RPCs的激活顺序和时间保持高度一致,这表明这些细胞高度专门编码奖励位置。在CA1和耻骨下的RPC放电与预期行为相一致,例如在接近奖励位置时减慢速度和预期舔食。作者发现,RPC在当前奖励位置的放电大约是先前训练的奖励位置的五倍,而预期行为在两个位置相似,这表明RPC并不直接编码行为。总的来说,这些数据表明,即使在包含奖励的位置或环境发生变化时,耻骨下和CA1中的细胞群也会对奖励的位置进行高度一致的编码。
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引用次数: 0
Across Canada 在加拿大
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-32
John B. Nicholson
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引用次数: 0
Exceptional Pleasures 特殊的乐趣
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-17
John B. Nicholson
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引用次数: 0
The Act of Reading 阅读的行为
Pub Date : 2019-12-05 DOI: 10.4324/9780367809416-9
John B. Nicholson
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引用次数: 0
Literary Criticism 文学批评
Pub Date : 2019-12-05 DOI: 10.4324/9781351320689-9
John B. Nicholson
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引用次数: 0
期刊
Reading and the Art of Librarianship
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