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بهینه سازی فرآیند اکسیداسیون پیشرفته بر پایه پرسولفات (UV/Na2S2O8/Fe2+) برای حذف فتالیک اسید از محلولهای آبی توسط روش سطح پاسخ
Q4 Medicine Pub Date : 2018-02-15 DOI: 10.18869/ACADPUB.JBUMS.20.2.13
مجتبی یگانه بادی, سودا فلاح جوکندان, علی اسرافیلی, سمیرا یوسف زاده, احسان احمدی, علی محسن پور آذری, سید احمد مختاری, سلیمه رضایی نیا, میترا غلامی
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引用次数: 1
Production of recombinant CAMP – Sialidase protein and preparation of chitosan nanoparticles carrying this protein to be used as a candidate for vaccines targeting Propionibacterium acnes 重组CAMP -唾液酸酶蛋白的制备及壳聚糖纳米颗粒的制备及其在痤疮丙酸杆菌疫苗中的应用
Q4 Medicine Pub Date : 2018-02-10 DOI: 10.18869/ACADPUB.JBUMS.20.2.64
P. Zargham, M. Heshmati, K. Mansouri, J. Amani, J. Salimian, A. Ahmadi
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引用次数: 2
The Study of Abnormal Liver Ultrasound Findings in Candidate Patients Undergoing Renal Transplantation from Brain Dead Donors 脑死亡供体肾移植候选患者肝脏超声异常表现的研究
Q4 Medicine Pub Date : 2018-02-10 DOI: 10.18869/ACADPUB.JBUMS.20.2.22
M. Sadeghi, M. Aliakbarian, Shaghayegh Beshtar, N. Samiee, E. Khaleghi
BACKGROUND AND OBJECTIVE: Chronic kidney disease in addition to kidney involvement may cause abnormalities in various systems of the body, in which liver disorders are one of the most commonly encountered disorders. Failure to identify some of these disorders can cause a serious problem in transolant patient. This study was performed to determine the frequency and type of abnormal liver ultrasound findings in renal transplant patients. METHODS: In this cross-sectional study, recorded data of 480 kidney failure patients who had received kidney transplant from brain death donors during the last 6 years in three Mashhad hospitals were investigated. Ultrasonography was considered before the transplant and abnormal liver findings were recorded in a checklist and were assesed. FINDINGS: The mean age was 39.07±12.67 years of which 52.70% were male and 42.30% were female. Liver disorders were observed in 13.12% of patients. The highest prevalence was related to fatty liver grade I (2.5%), grade II (1.46%), gallstone (1.25%) and liver cysts (1.25%). CONCLUSION: The results of the study showed that liver asymptomatic disorders in renal transplant patients have significant prevalence and because some of these disorders require treatment before transplantation, enough attention to screening before transplantation can help to prevent post-transplant complications.
背景与目的:慢性肾脏疾病除了累及肾脏外,还可引起身体各系统的异常,其中肝脏疾病是最常见的疾病之一。不能识别这些疾病中的一些可能会导致严重的问题在易感患者。本研究旨在确定肾移植患者肝脏超声异常的频率和类型。方法:在这项横断面研究中,对过去6年中在马什哈德三家医院接受脑死亡供体肾移植的480例肾衰竭患者的记录数据进行了调查。移植前考虑超声检查,肝脏异常检查结果记录在检查表中并进行评估。结果:患者平均年龄39.07±12.67岁,其中男性占52.70%,女性占42.30%。13.12%的患者出现肝脏疾病。患病率最高的是脂肪肝I级(2.5%)、II级(1.46%)、胆结石(1.25%)和肝囊肿(1.25%)。结论:本研究结果显示,肾移植患者中肝脏无症状性疾病的发生率显著,由于其中一些疾病需要在移植前治疗,因此在移植前足够重视筛查有助于预防移植后并发症。
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引用次数: 0
A Comparison of the Effect of Ondansetron and Propofol on Intrathecal Opioid-Induced itch in Elective Cesarean Section 昂丹司琼与异丙酚对选择性剖宫产术鞘内阿片瘙痒的影响比较
Q4 Medicine Pub Date : 2018-02-10 DOI: 10.18869/ACADPUB.JBUMS.20.2.7
A. Mahouri, S. Sane, E. Hassani, H. Rezaie, L. Aghasi
J Babol Univ Med Sci; 20(2); Feb 2018; PP: 7-12 Received: Jun 12 2017, Revised: Sep 23 2017, Accepted: Dec 2 2017. ABSTRACT BACKGROUND AND OBJECTIVE: Itch is one of the most common and uncomfortable side effects of neuraxial anesthesia. Its incidence is higher especially in cesarean section. The aim of this study was to compare the effect of ondansetron and propofol at doses lower than the hypnotic dose on the treatment of itch induced by intrathecal fentanyl in cesarean section. METHODS: In this prospective study, 90 patients with American Society of Anesthesiologists (ASA) class I and class II with an average age of 30 years and first time cesarean section underwent intra-spinal anesthesia with 25 μg fentanyl and 10 mg bupivacaine 0.5%. Women were randomly divided into two groups of 45. One group received 4 mg ondansetron and another group received 10 mg propofol at first and then 10 μg/kg / min through infusion. The incidence and severity of itch were recorded on the basis of the visual scoring system during operation and during recovery. FINDINGS:The highest incidence of itch was 30 to 60 minutes after injection. The incidence of itch during surgery was 2.22% and 7.26%, and during recovery was 7.6% and 8.8%, in the ondansetron and propofol groups, respectively (p=0.5, p=0.4). The mean itch severity scores during surgery were 1.85±0.69 and 1.66±0.81, and during the recovery were 1.33±0.57 and 1.25±0.5, in the ondansetron and propofol groups, respectively (p=0.65) (p=0.84). CONCLUSION: Based on the results of this study, ondansetron and propofol at doses lower than the hypnotic dose were well tolerated. Considering the effect of both drugs on the treatment of itch caused by intrathecal fentanyl, both of them can be used clinically.
巴宝勒大学医学杂志;20 (2);2018年2月;收稿日期:2017年6月12日,修稿日期:2017年9月23日,收稿日期:2017年12月2日。背景与目的:瘙痒是神经轴麻最常见和最不舒服的副作用之一。其发病率较高,尤其是剖宫产。本研究的目的是比较低于催眠剂量的昂丹司琼和异丙酚对剖宫产术中芬太尼鞘内致痒的治疗效果。方法:在本前瞻性研究中,90例平均年龄30岁的美国麻醉学会(ASA) I类和II类首次剖宫产患者行芬太尼25 μg + 0.5%布比卡因10 mg脊髓内麻醉。女性被随机分为两组,每组45人。一组患者先给予昂丹西琼4 mg,另一组患者先给予异丙酚10 mg,后经静脉滴注10 μg/kg / min。根据视觉评分系统记录手术期间和恢复期间瘙痒的发生率和严重程度。发现:注射后30 ~ 60分钟瘙痒发生率最高。昂丹司琼组和异丙酚组术中瘙痒发生率分别为2.22%和7.26%,恢复期间瘙痒发生率分别为7.6%和8.8% (p=0.5, p=0.4)。昂丹司琼组和异丙酚组手术时瘙痒严重程度平均评分分别为1.85±0.69和1.66±0.81,恢复时瘙痒严重程度平均评分分别为1.33±0.57和1.25±0.5 (p=0.65) (p=0.84)。结论:根据本研究结果,低于催眠剂量的昂丹司琼和异丙酚耐受性良好。考虑到两种药物治疗鞘内芬太尼引起的瘙痒的效果,两种药物均可在临床上使用。
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引用次数: 0
The Role of Iron Oxide Nanoparticles and Magnetic Field on Apoptosis and Bax Gene Expression in Rat Hippocampus after Ischemic Reperfusion 氧化铁纳米颗粒和磁场对大鼠缺血再灌注后海马细胞凋亡和Bax基因表达的影响
Q4 Medicine Pub Date : 2018-02-10 DOI: 10.18869/ACADPUB.JBUMS.20.2.42
Sh Bagheri Tari, Z. K. Koohpar, M. Falahati
J Babol Univ Med Sci; 20(2); Feb 2018; PP: 42-8 Received: Jan 7 2017, Revised: Oct 22 2017, Accepted: Dec 12 2017. ABSTRACT BACKGROUND AND OBJECTIVE: Stroke is the second leading cause of mortality in the worldwide. After a stroke, many neurons in the ischemic penumbra will undergo apoptosis. The aim of this study was investigation of effects of iron oxide nanoparticles and magnetic field on apoptosis reduction after ischemic reperfusion in rat model. METHODS: In this experimental study, 50 male Wistar rats weighing 220-250g were randomly divided into five groups of 10 rats each: including control, sham (ischemic reperfusion model), ischemic reperfusion+iron oxide nanoparticles (10mg/kg), ischemic reperfusion +magnetic field (1 Tesla, 20 min in 4 days), and ischemic reperfusion+iron oxide nanoparticles and magnetic field groups. Injections were performed intraperitoneally. After Four days, the hippocampi were removed for studying of Apoptosis Induction (by TUNEL technique) and changes in Bax gene expression (by Q-PCR method). FINDINGS: After induction of ischemic reperfusion, TUNEL+ cells number treated with iron oxide nanoparticles (7±2) and or the magnetic field (12±2) had significant decrease (p<0.01) relative to ischemic reperfusion group (27±5) during 4 days. But simultaneous treatment with nanoparticles and magnetic field (23±2.6) did not show significant difference compared to ischemic reperfusion group (27±5) during 4 days. Furthermore Bax gene expression decreased in iron oxide nanoparticles treated group (2.46±0.22) or the magnetic field exposed group (3.28±0.33) significantly (p<0.01)compared to ischemic reperfusion model (5.21±0.73).. CONCLUSION: It seems that iron oxide nanoparticles as well as magnetic field to be two effective methods in decrease of apoptosis after ischemic reperfusion.
巴宝勒大学医学杂志;20 (2);2018年2月;收稿日期:2017年1月7日,修稿日期:2017年10月22日,收稿日期:2017年12月12日。背景与目的:脑卒中是全球第二大死亡原因。脑卒中后,缺血半暗带的许多神经元发生凋亡。本研究旨在探讨氧化铁纳米颗粒和磁场对大鼠缺血再灌注后细胞凋亡减少的影响。方法:选取体重220 ~ 250g的雄性Wistar大鼠50只,随机分为5组,每组10只:对照组、假手术(缺血再灌注模型)、缺血再灌注+氧化铁纳米颗粒(10mg/kg)组、缺血再灌注+磁场组(1 Tesla, 4 d 20 min)、缺血再灌注+氧化铁纳米颗粒+磁场组。采用腹腔注射。4 d后,取海马进行凋亡诱导(TUNEL法)和Bax基因表达变化(Q-PCR法)的研究。结果:缺血再灌注诱导后4 d内,氧化铁纳米颗粒(7±2)和磁场(12±2)处理的TUNEL+细胞数量较缺血再灌注组(27±5)显著减少(p<0.01)。但与缺血再灌注组(27±5)相比,纳米颗粒与磁场同时处理(23±2.6)天无显著差异。与缺血再灌注模型(5.21±0.73)相比,氧化铁纳米颗粒处理组(2.46±0.22)和磁场暴露组(3.28±0.33)Bax基因表达显著降低(p<0.01)。结论:氧化铁纳米颗粒和磁场是减少缺血再灌注后细胞凋亡的两种有效方法。
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引用次数: 1
Relationship between Severity of Nasal Septum Deviation and Pneumatization of Mastoid Cells and Chronic Otitis Media 鼻中隔偏曲程度与乳突细胞气化与慢性中耳炎的关系
Q4 Medicine Pub Date : 2018-02-10 DOI: 10.18869/ACADPUB.JBUMS.20.2.27
E. Shobeiri, M. Salehi, A. Jalalvandian
J Babol Univ Med Sci; 20(2); Feb 2018; PP: 27-32 Received: Oct 15 2017, Revised: Jan 23 2018, Accepted: Mar 3 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Nasal septum deviation (NSD) is one of the leading causes of chronic otitis media and pneumatization of mastoid air cells. In this study, the effect of NSD on pneumatization of mastoid cells and the relationship between NSD and chronic otitis media were investigated using CT scan. METHODS: In this cross-sectional study, 75 paranasal sinus CT scans with NSD and mastoid view were investigated. Patients were divided into three groups based on the severity of NSD: mild (deviation less than 9 degrees, 25 patients), moderate (deviation from 9 to 15 degrees, 25 patients) and severe (deviation equal to or greater than 15 degrees, 25 patients). Chronic otitis media is defined as the presence of bone destruction or sclerosis accompanied by mass fluid or structural changes in temporal bone air cells. The pneumatization of mastoid cells was determined visually and as formation of mastoid air cells. FINDINGS: There was no significant difference in the frequency of pneumatization of mastoid cells between mild (25 patients, 100%), moderate (25 patients, 100%) and severe (23 patients, 92%) nasal septum deviation (p = 0.128). However, the prevalence of chronic otitis media was significantly higher in severe NSD (13 patients, 52%) compared to mild (4 patients, 16%) and moderate (9 patients, 36%) NSD (p = 0.028) CONCLUSION: The results of the study showed that the severity of NSD does not have an effect on pneumatization of mastoid cells, but severe NSD increases the frequency of otitis media.
巴宝勒大学医学杂志;20 (2);2018年2月;收稿日期:2017年10月15日,修稿日期:2018年1月23日,收稿日期:2018年3月3日。背景与目的:鼻中隔偏曲(NSD)是慢性中耳炎和乳突空气细胞气化的主要原因之一。本研究通过CT扫描探讨了NSD对乳突细胞气化的影响以及NSD与慢性中耳炎的关系。方法:在这个横断面研究中,研究了75副鼻窦CT扫描的NSD和乳突视图。根据NSD的严重程度将患者分为轻度(偏差小于9度,25例)、中度(偏差9 ~ 15度,25例)和重度(偏差等于或大于15度,25例)三组。慢性中耳炎定义为伴有颞骨空气细胞大量液体或结构改变的骨破坏或硬化症。目测乳突细胞气化及乳突空气细胞形成。结果:轻度(25例,100%)、中度(25例,100%)和重度(23例,92%)鼻中隔偏曲的乳突细胞气化频率无显著差异(p = 0.128)。而重度NSD(13例,52%)的慢性中耳炎患病率明显高于轻度(4例,16%)和中度(9例,36%)的NSD (p = 0.028)。结论:研究结果表明,NSD的严重程度对乳突细胞的气化没有影响,但重度NSD增加了中耳炎的发生频率。
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引用次数: 3
مقایسه کارایی نسبی بیمارستانهای وابسته به علوم پزشکی بابل و مازندران قبل و بعد از طرح تحول سلامت با تکنیک تحلیل پوششی داده ها
Q4 Medicine Pub Date : 2018-01-15 DOI: 10.18869/acadpub.jbums.20.1.68
اباذر عموزاده دوغیکلا, رضا شاه وردی, فرزاد رضائی بالف
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引用次数: 0
Effect of Ursodeoxycholic Acid on Pentylenetetrazole Kindling and Kindling Induced Memory Impairment in Rat 熊去氧胆酸对戊四唑点火及点火所致大鼠记忆损伤的影响
Q4 Medicine Pub Date : 2018-01-15 DOI: 10.18869/ACADPUB.JBUMS.20.1.56
مریم نادری, ابوالفضل ژند, یحیی ژند, تینا رهجو, محمدرضا پالیزوان
BACKGROUND AND OBJECTIVE: Epilepsy is one of the common diseases of the brain that about 30-40 of patients with epilepsy experience recurent attacks due to drug resistance. Recently, the beneficial effects of Ursodeoxycholic acid on brain disorders have been considered. The aim of this study was to evaluate the effect of Ursodeoxycholic acid(UDCA)on the Pentylenetetrazole (PTZ) induced kindling, and related learning and memory impairments on Morris water maze. METHODS: This experimental study was done on 32 male Winstar rats divided into 4 groups. The first(n=7)and the second (n=9) groups have received three injections of 0.5 ml NaCl or 50 mg/kg of UDCA respectively and third(n=7) and fourth(n=9) groups have received fifteen injections of 0.5 ml NaCl or 50 mg/kg of UDCA respectively. All injections were given intraperitoneally(ip)(every 48 hours). In all groups, chemical kindling were started after third injections. Twenty-four hour after the last injection, spatial memory was investigated in the Morris water maze. FINDING: Fifteen injections of UDCA significantly reduced the seizure stage from 3.5±0.17 to 3.08±0.11 and duration of stages five from 12.38±1.2 to 8.61±0.58 and increased time to reach the stage five seizures from 1021.65±72.07 to 1252.41±49.63 as compared to control group. However, three injections of UDCA have no effect on the kindling process. However, three time administration of UDCA significantly increased reference memory from 18.72±1.2 s to 26.11±1.8 s. CONCLUSION: Ursodeoxycholic acid inhibits chemical kindling and improves kindling induced memory impairment. © 2018, Babol University of Medical Sciences. All rights reserved.
背景与目的:癫痫是脑部常见疾病之一,约30- 40%的癫痫患者因耐药而反复发作。最近,熊去氧胆酸对脑部疾病的有益作用已被考虑。本研究旨在探讨熊去氧胆酸(UDCA)对戊四唑(PTZ)诱导的Morris水迷宫学习记忆障碍的影响。方法:选用雄性Winstar大鼠32只,分为4组。第一组(n=7)和第二组(n=9)分别注射3次0.5 ml NaCl或50 mg/kg UDCA,第三组(n=7)和第四组(n=9)分别注射15次0.5 ml NaCl或50 mg/kg UDCA。所有注射均为腹腔注射(ip)(每48小时)。所有组均在第三次注射后开始化学点火。末次注射24小时后,Morris水迷宫观察空间记忆。结果:与对照组相比,15次注射UDCA可将癫痫发作期从3.5±0.17缩短至3.08±0.11,将五期持续时间从12.38±1.2缩短至8.61±0.58,将达到五期癫痫发作的时间从1021.65±72.07缩短至1252.41±49.63。然而,三次注射UDCA对点燃过程没有影响。然而,三次给药UDCA显著增加参考记忆,从18.72±1.2 s增加到26.11±1.8 s。结论:熊去氧胆酸可抑制化学引燃,改善引燃引起的记忆障碍。©2018,巴博勒医学科学大学。版权所有。
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引用次数: 1
اثربخشی آب، شیر و آب لیموی طبیعی درترشح کبدی-صفراوی رادیوداروی99mTc-MIBI دراسکن پرفیوژن قلب
Q4 Medicine Pub Date : 2018-01-10 DOI: 10.18869/acadpub.jbums.20.1.12
سید حسین موسوی انیجدان, امیر غلامی
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引用次数: 1
A Case Report of Asymptomatic Glandular Odontogenic Cyst Mimicking as a Nasopalatine Duct Cyst 无症状腺源性牙源性囊肿酷似鼻腭管囊肿1例
Q4 Medicine Pub Date : 2018-01-10 DOI: 10.18869/acadpub.jbums.20.1.7
S. Nafarzadeh, A. Pournabi, F. Bijani
BACKGROUND AND OBJECTIVE: Glandular odontogenic cyst is a rare developmental odontogenic cyst which most frequently occures in mandible. According to low incidence and unusual shape and location of this case, we decided to report the case. CASE REPORT: Here we present an asymptomatic case in anterior part of maxilla that radiographically was small and unilacular mimicking as a nasopalatine duct cyst. We have found it incidentally through radiographic evaluation before implant insertion. After enucleation and curettage, histopathologic evaluation revealed a glandular odontogenic cyst. In three months follow-up, no complication or recurrence was noticed, and the site of the lesion has filled with
背景与目的:腺性牙源性囊肿是一种罕见的发育性牙源性囊肿,常见于下颌骨。鉴于该病例发病率低,且形状和位置不寻常,我们决定报告该病例。病例报告:在这里我们提出一个无症状的病例,在上颌前部的x线片是小的和单束模拟鼻腭管囊肿。我们是在植入前通过x线片评估偶然发现的。在去核和刮除后,组织病理学检查显示为腺性牙源性囊肿。随访3个月,未见并发症和复发,病灶部位充盈
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引用次数: 0
期刊
Journal of Babol University of Medical Sciences
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