Pub Date : 2018-07-10DOI: 10.18869/ACADPUB.JBUMS.20.7.71
E. Nasiri, R. Gazor, S. Fathi
BACKGROUND AND OBJECTIVE: Abnormal origin of coronary arteries, which are responsible for providing the heart with freshly oxygenated blood, can lead to complications affecting daily activity. This variation could be harmless and controlable with the aid of medication but sometimes the bad anatomical situation requires operation. In this severe types, early diagnosis is very important. The aim of thid study was to teach medical students about coronary arteries’ anomalies. CASE REPORT: Through the thorax dissection sessions of a 57 years old man, we observed that the right coronary artery along with the left main coronary artery is originated from the left sinus of Valsalva. As it passed posteriorly to the aorta, it could have been pressed by the esophagus or the right auricle of the right atrium. CONCLUSION: This study showed that the right coronary artery arises from left sinus of Valsalva. Together with the significant cardiomegaly and extra pericardial fat, this abnormally originated right coronary artery could be one of the main causes of this person’s health complications while alive.
{"title":"A Case Report of Abnormal Branched Right Coronary Artery from Left Sinus of Valsalva","authors":"E. Nasiri, R. Gazor, S. Fathi","doi":"10.18869/ACADPUB.JBUMS.20.7.71","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.71","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Abnormal origin of coronary arteries, which are responsible for providing the heart with freshly oxygenated blood, can lead to complications affecting daily activity. This variation could be harmless and controlable with the aid of medication but sometimes the bad anatomical situation requires operation. In this severe types, early diagnosis is very important. The aim of thid study was to teach medical students about coronary arteries’ anomalies. CASE REPORT: Through the thorax dissection sessions of a 57 years old man, we observed that the right coronary artery along with the left main coronary artery is originated from the left sinus of Valsalva. As it passed posteriorly to the aorta, it could have been pressed by the esophagus or the right auricle of the right atrium. CONCLUSION: This study showed that the right coronary artery arises from left sinus of Valsalva. Together with the significant cardiomegaly and extra pericardial fat, this abnormally originated right coronary artery could be one of the main causes of this person’s health complications while alive.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"7 1","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85286006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-10DOI: 10.18869/ACADPUB.JBUMS.20.7.47
M. Theri, S. Nazarian, F. Ebrahimi, Mostafa Bakhshi, Javad Fathi
J Babol Univ Med Sci; 20(7); July 2018; PP: 47-54 Received: Nov 14 2017, Revised: Mar 14 2018, Accepted: Mar 26 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Escherichia coli enterohemorrhagic (EHEC) causes diarrhea, hemolysis colitis, and uremic hemolytic syndrome. Due to the dangers of antibiotic treatment in the EHEC O157: H7 infection, vaccines offer a promising way to prevent infection. The purpose of this study was to investigate the immunity of recombinant proteins Intimin, EspA and Stx2b against infection of E. coli O157 H7. METHODS: In this research study, expression of recombinant Intimin, EspA and Stx2b proteins E.coli BL21 DE3 was induced with IPTG. Recombinant proteins were examined by Western Blot and purified using the affinity Ni-NTA chromatography. Subcutaneous and intraperitoneally immunization of mice was performed and the antibody titer was determined by ELISA. The mice were orally infected with bacteria and the bacterial loss and mortality of the mice were examined. FINDINGS: SDS-PAGE analysis showed expression of proteins with 11,17 and 34 kDa molecular weight. The recombinant proteins were confirmed by Western Blot. ELISA end point titer for humoral response to EspA, Intimin and Stx2b was 25600. The loss of bacteria in mice was 10 cfu / ml and mortality rate were reduced to 60 Percent. CONCLUSION: The results showed that immune response against EspA, Intimin and Stx2b proteins protects animals against challenges using E. coli O157: H7.
{"title":"Immunization Evaluation of Type III Secretion System Recombinant Antigens and Shiga Like Toxin Binding Subunit of E. coli O157:H7","authors":"M. Theri, S. Nazarian, F. Ebrahimi, Mostafa Bakhshi, Javad Fathi","doi":"10.18869/ACADPUB.JBUMS.20.7.47","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.47","url":null,"abstract":"J Babol Univ Med Sci; 20(7); July 2018; PP: 47-54 Received: Nov 14 2017, Revised: Mar 14 2018, Accepted: Mar 26 2018. ABSTRACT BACKGROUND AND OBJECTIVE: Escherichia coli enterohemorrhagic (EHEC) causes diarrhea, hemolysis colitis, and uremic hemolytic syndrome. Due to the dangers of antibiotic treatment in the EHEC O157: H7 infection, vaccines offer a promising way to prevent infection. The purpose of this study was to investigate the immunity of recombinant proteins Intimin, EspA and Stx2b against infection of E. coli O157 H7. METHODS: In this research study, expression of recombinant Intimin, EspA and Stx2b proteins E.coli BL21 DE3 was induced with IPTG. Recombinant proteins were examined by Western Blot and purified using the affinity Ni-NTA chromatography. Subcutaneous and intraperitoneally immunization of mice was performed and the antibody titer was determined by ELISA. The mice were orally infected with bacteria and the bacterial loss and mortality of the mice were examined. FINDINGS: SDS-PAGE analysis showed expression of proteins with 11,17 and 34 kDa molecular weight. The recombinant proteins were confirmed by Western Blot. ELISA end point titer for humoral response to EspA, Intimin and Stx2b was 25600. The loss of bacteria in mice was 10 cfu / ml and mortality rate were reduced to 60 Percent. CONCLUSION: The results showed that immune response against EspA, Intimin and Stx2b proteins protects animals against challenges using E. coli O157: H7.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"18 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83771988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-10DOI: 10.18869/ACADPUB.JBUMS.20.7.21
AJ Mozafari Comeshtappeh, M. Feridoni, M. Falsafi, SM Esmaeilnejad Ganji
1.Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran 2.Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol I.R.Iran 3.Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran 4.Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, I.R.Iran.
{"title":"Prevalence of Musculoskeletal Pains and the Demographic Factors Related to the Pain Locations in Patients with Chronic Trauma","authors":"AJ Mozafari Comeshtappeh, M. Feridoni, M. Falsafi, SM Esmaeilnejad Ganji","doi":"10.18869/ACADPUB.JBUMS.20.7.21","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.21","url":null,"abstract":"1.Student Research Committee, Babol University of Medical Sciences, Babol, I.R.Iran 2.Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol I.R.Iran 3.Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, I.R.Iran 4.Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, I.R.Iran.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"61 1","pages":"21-27"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77160003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-10DOI: 10.18869/ACADPUB.JBUMS.20.7.28
M. Hosseinpourfeizi, S. Dianati, A. Samir, Narges Dastmalchi, N. Pouladi
1.Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, I.R.Iran 2.Department of Biology, Faculty of Sciences, Azad University of Ahar, Ahar, I.R.Iran 3.Department of Biology, Faculty of Sciences, Payam-Noor University of Rey, Rey, I.R.Iran 4.Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, I.R.Iran 5.Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, I.R.Iran
{"title":"Investigation of Mutations of Exon 11-A of BRCA1 Gene in Women with Breast Cancer in the Northwest of Iran","authors":"M. Hosseinpourfeizi, S. Dianati, A. Samir, Narges Dastmalchi, N. Pouladi","doi":"10.18869/ACADPUB.JBUMS.20.7.28","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.28","url":null,"abstract":"1.Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, I.R.Iran 2.Department of Biology, Faculty of Sciences, Azad University of Ahar, Ahar, I.R.Iran 3.Department of Biology, Faculty of Sciences, Payam-Noor University of Rey, Rey, I.R.Iran 4.Department of Animal Sciences, Faculty of Natural Sciences, University of Tabriz, Tabriz, I.R.Iran 5.Department of Biology, Faculty of Sciences, Azarbaijan Shahid Madani University, Tabriz, I.R.Iran","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"154 ","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72438843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review of the Indices of Mizaj-e-Meda (Temperament of Stomach) identification in Persian Medicine","authors":"E. Parsa, M. Mojahedi, M. C. Raghimi, R. Ilkhani, A. Zareiyan, R. Mokaberinejad, M. A. Vaghasloo, Mahmood Khodadoost","doi":"10.18869/ACADPUB.JBUMS.20.7.63","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.63","url":null,"abstract":"J Babol Univ Med Sci; 20(7); July 2018; PP: 63-70 Received: Jan 8 2018, Revised: Mar 14 2018, Accepted: Apr 1","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"298 1","pages":"63-70"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74784937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-07-10DOI: 10.18869/ACADPUB.JBUMS.20.7.33
M. Pitka, H. Shafi, A. Nazemi
{"title":"T375c Mutation of FGFR3 Gene in Bladder Epithelial Cells of Patients with Bladder Cancer","authors":"M. Pitka, H. Shafi, A. Nazemi","doi":"10.18869/ACADPUB.JBUMS.20.7.33","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.33","url":null,"abstract":"","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"61 1","pages":"33-39"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80481137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inhaled Beclomethasone with or whiteout Montelukast in the Management of Pediatric Persistent Asthma","authors":"I. Mohammadzadeh, A. Modanloo, R. Alizadeh-Navaei","doi":"10.18869/ACADPUB.JBUMS.20.7.7","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.7.7","url":null,"abstract":"J Babol Univ Med Sci; 20(7); July 2018; PP: 7-13 Received: Nov 25 2017, Revised: Feb 1","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"4 1","pages":"7-13"},"PeriodicalIF":0.0,"publicationDate":"2018-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90998578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-06-15DOI: 10.18869/ACADPUB.JBUMS.20.6.36
Z. Lorigooini, S. Ghasemi, N. Dehkordi, M. Motamedi
BACKGROUND AND OBJECTIVE: Tricin as a flavone compound, in many food sources, has anti-inflammatory and anti-proliferative effects in several cancer cell lines. Considering the importance of using natural anti-cancer drugs in treatment-resistant cancers such as prostate cancer, the aim of this study was to investigate the effect of tricin on cell growth and proliferation and induction of apoptosis in human PC3 prostate cancer cell line. METHODS: In this experimental study, the PC3 cell line was prepared from the Pasteur Institute of Iran and cultivated. Extraction and purification of Tricin were performed using column chromatography and re-crystallization of Alliuum atrovoilaceum extract. The cytotoxic effect of Tricin in concentrations of 60,80,100,120, and 140 μM was evaluated by MTT method. Apoptotic effect was evaluated in the treated cell group with the IC50 concentration of Tricin and untreated cells (control group), using an Annexin-V kit and flow cytometry. FINDINGS: The viability of cells at different tricin concentrations were 85.66±1.52, 76±3.60, 66.33±4.16, 44±3.60, and 36.66±3.21, respectively (p<0.01). The IC50 concentration of tricin was 117.5±4.4 μM for PC3 cell line. The apoptosis rate in PC3 cells after 48 hours of treatment with IC50 concentration of tricin was 24.3±0.58%, which was not significant in comparison with control cells (23.3±0.58%). CONCLUSION: The results of this study showed that Tricin resulted in cell death in the PC3 cell line, but the cell death mechanism was not apoptosis.
{"title":"Effect of Isolated Tricin from Arial Part of Allium atrovoilaceum Boiss. on Proliferation and Apoptosis in PC3 Cell Line","authors":"Z. Lorigooini, S. Ghasemi, N. Dehkordi, M. Motamedi","doi":"10.18869/ACADPUB.JBUMS.20.6.36","DOIUrl":"https://doi.org/10.18869/ACADPUB.JBUMS.20.6.36","url":null,"abstract":"BACKGROUND AND OBJECTIVE: Tricin as a flavone compound, in many food sources, has anti-inflammatory and anti-proliferative effects in several cancer cell lines. Considering the importance of using natural anti-cancer drugs in treatment-resistant cancers such as prostate cancer, the aim of this study was to investigate the effect of tricin on cell growth and proliferation and induction of apoptosis in human PC3 prostate cancer cell line. \u0000METHODS: In this experimental study, the PC3 cell line was prepared from the Pasteur Institute of Iran and cultivated. Extraction and purification of Tricin were performed using column chromatography and re-crystallization of Alliuum atrovoilaceum extract. The cytotoxic effect of Tricin in concentrations of 60,80,100,120, and 140 μM was evaluated by MTT method. Apoptotic effect was evaluated in the treated cell group with the IC50 concentration of Tricin and untreated cells (control group), using an Annexin-V kit and flow cytometry. \u0000FINDINGS: The viability of cells at different tricin concentrations were 85.66±1.52, 76±3.60, 66.33±4.16, 44±3.60, and 36.66±3.21, respectively (p<0.01). The IC50 concentration of tricin was 117.5±4.4 μM for PC3 cell line. The apoptosis rate in PC3 cells after 48 hours of treatment with IC50 concentration of tricin was 24.3±0.58%, which was not significant in comparison with control cells (23.3±0.58%). \u0000CONCLUSION: The results of this study showed that Tricin resulted in cell death in the PC3 cell line, but the cell death mechanism was not apoptosis.","PeriodicalId":15108,"journal":{"name":"Journal of Babol University of Medical Sciences","volume":"27 1","pages":"36-40"},"PeriodicalIF":0.0,"publicationDate":"2018-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82574542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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