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Journal of NBC Protection Corps最新文献

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Frontmatter
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-fm
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引用次数: 0
NBC Time Line NBC时间线
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-025
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引用次数: 0
2. “Always in Friendly Competition”: NBC and CBS in the First Decade of National Broadcasting 2. “永远在友好竞争中”:NBC和CBS在国家广播的第一个十年
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-005
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引用次数: 1
Illustrations 插图
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-001
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引用次数: 0
Introduction to Part One: Broadcasting Begins, 1919–38 第一部分导言:广播开始,1919-38年
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-003
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引用次数: 0
8. NBC, J. Walter Thompson, and the Struggle for Control of Television Programming, 1946–58 8. NBC、j·沃尔特·汤普森与电视节目控制权之争,1946 - 1958
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-012
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引用次数: 1
12. The Little Program That Could: The Relationship between NBC and Star Trek 12. 小节目:NBC和星际迷航的关系
Pub Date : 2019-12-31 DOI: 10.1525/9780520940604-017
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引用次数: 0
Immunotropic and Immunogenic Properties of Nonspecific Yersinia Porins 非特异性耶尔森菌孔蛋白的免疫亲和性和免疫原性
Pub Date : 2019-12-05 DOI: 10.35825/2587-5728-2019-3-4-350-372
The purpose of the study is to summarize our own data and literature data on the signifi cance of poreforming proteins of the outer membrane of Yersinia as factors of their pathogenicity and as diagnostic and protective antigens, and their role in pathological processes considered non-infectious. In the last decades of the last century, the epidemic signifi cance of intestinal yersiniosis caused by the bacteria of Yersinia genus, Yersinia pseudotuberculosis and Yersinia enterocolitica, which are the «doubles» of the plague pathogen (Yersinia pestis) by genetic, cultural, biochemical, and other properties, has signifi cantly increased. It has been established that acute yersiniosis infections without eff ective treatment can pass into secondary focal forms, leading to the development of systemic diseases that were not previously considered infectious (for example, Grave’s disease). Th ey are characterized by multiple organ lesions, dysfunctions of the cardiovascular and nervous systems, musculoskeletal system, urinary system and gastrointestinal tract, which is a consequence of autoimmune processes based on the ability of Yersinia to molecular mimicry. Th e paper shows that porins play a signifi cant role in the development of the infectious process and can be considered as pathogenic factors of bacteria. Together with other components of the outer membrane of gram negative bacteria, they provide adhesion, invasion and colonization of the cells of the host organism by bacteria. Porins can aff ect a number of eukaryotic cell functions, including cytokine expression, receptor activation, apoptosis induction, and regulation of the actin cytoskeleton. It has been established that pore-forming Yersinia proteins are protective antigens. The administration of them to laboratory animals induces the formation of species-specifi c immunity, which allows us to recommend porin protein as a component of chemical and genetic engineering vaccines. Porins are promising for the development of ELISA test systems for the diagnosis of pseudotuberculosis and intestinal yersiniosis, as well as immunopathologies caused by Yersinia bacteria. Given the high degree of similarity of the primary structures of Yersinia porins, it can be assumed that protective preparations created on their basis will protect against infections caused by intestinal yersiniosis, pseudotuberculosis and plague pathogens
本研究的目的是总结我们自己的资料和文献资料,关于耶尔森氏菌外膜的孔改造蛋白作为其致病性因素和诊断性和保护性抗原的意义,以及它们在被认为是非传染性的病理过程中的作用。在上世纪最后几十年,由鼠疫病原体(鼠疫耶尔森氏菌)的遗传、培养、生化和其他特性的“双重”耶尔森氏菌属、假结核耶尔森氏菌和小肠结肠炎耶尔森氏菌引起的肠道耶尔森氏菌病的流行意义显著增加。已经确定的是,未经有效治疗的急性耶尔森菌病感染可以转变为继发性局灶形式,导致以前不被认为具有传染性的全身性疾病的发展(例如格雷夫斯病)。它们的特点是多器官病变,心血管和神经系统、肌肉骨骼系统、泌尿系统和胃肠道功能障碍,这是基于耶尔森菌分子模仿能力的自身免疫过程的结果。本文表明,孔蛋白在感染过程的发展中起着重要的作用,可以认为是细菌的致病因素。它们与革兰氏阴性菌外膜的其他成分一起,提供细菌对宿主细胞的粘附、侵袭和定植。孔蛋白可以影响许多真核细胞功能,包括细胞因子表达、受体激活、细胞凋亡诱导和肌动蛋白细胞骨架的调节。已经确定形成孔的耶尔森氏菌蛋白是保护性抗原。将它们施用于实验动物可诱导形成物种特异性免疫,这使我们能够推荐将孔蛋白作为化学和基因工程疫苗的组成部分。在开发用于诊断假结核和肠道耶尔森菌病以及由耶尔森菌引起的免疫病变的ELISA检测系统方面,孔蛋白是有希望的。鉴于耶尔森氏菌孔蛋白初级结构的高度相似性,可以假设在其基础上制备的保护性制剂将防止肠道耶尔森氏菌病、假结核和鼠疫病原体引起的感染
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引用次数: 0
The Possibilities of Working Capacity Maintenance at Organophosphorous Compounds Intoxication 有机磷化合物中毒后工作能力维持的可能性
Pub Date : 2019-12-05 DOI: 10.35825/2587-5728-2019-3-4-311-318
Th e experience of modern local armed confl icts and the monitoring of terrorist activity in the world indicate the possibility of the aff ection of people by organophosphorus compounds (OPs) in combat and as a result of industrial accidents and terrorist acts. It can be predicted that in case of timely use of PPE by the personnel, in addition to lethal and severe aff ections, up to 30 ± 5% of them will be mild forms of intoxication. It is shown in the article, that the actoprotectors with diff erent mechanism of action (hypoxene, octodrine and meldonium) increase the endurance of experimental animals with mild poisoning of OPs in case of single oral administration. Moreover, the degree of inhibition of peripheral blood acetylcholinesterase of all animals treated with model OPs did not diff er between groups and ranged from 8 to 24%. As a result of the experiments on animals, the preparations were distributed in the following order: meldonium
现代地方武装冲突的经验和世界上对恐怖主义活动的监测表明,在战斗中以及由于工业事故和恐怖主义行为,人们可能受到有机磷化合物的伤害。可以预见,在人员及时使用个人防护装备的情况下,除了致命和严重的中毒外,高达30±5%的人会出现轻度中毒。结果表明,不同作用机制的活性保护剂(亚氧苯、奥克得林和米屈肼)在单次口服的情况下,可提高OPs轻度中毒实验动物的耐力。此外,模型OPs对各组动物外周血乙酰胆碱酯酶的抑制程度无差异,在8% ~ 24%之间。动物实验结果显示,制剂的分布顺序为:米屈肼<奥克得林<亚氧二烯。联合口服试验物质不伴有活性保护作用的增强。可以确定的是,所研究的肌动保护剂的联合使用与米屈肼的单独给药相当,与使用奥克特林相比没有优势,在起效率上超过了亚氧芬,但在严重程度和持续时间上不如它。这些事实表明,使用所研究的活性保护剂在OPs(亚氧苯)中毒威胁下防止战备状态下降,在轻度aff(八克膦)中毒情况下紧急增加,以及在有机磷(OPs)中毒(米屈肼、亚氧苯)的复杂治疗方面是可行的。
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引用次数: 1
The Development of Special Interactive Teaching Computer Programs for the Training of the Specialists of Radiological, Chemical and Biological Defence Troops 放射、化学和生物防御部队专家培训专用交互式计算机教学程序的开发
Pub Date : 2019-12-05 DOI: 10.35825/2587-5728-2019-3-4-373-380
Th e development of any weapon system is carried out by the implementation of new technologies into the military equipment. Th e complexity and costliness of their adaptation require the increase of the intensity of personnel training with the simultaneous reduction of material and fi nancial costs. In this connection, it is an urgent task to arrange the conditions for the mass training of military specialists by the elaboration of the training facilities system that allow the trainees to acquire proper skills of the maintenance and combat employment of the weapons and the equipment of radiological, chemical and biological (RChB) defence in an accelerated manner. In order to solve this problem, the subprogram of the development of the system of technical means of training is developed within the framework of the Interspecifi c complex target program «Th e Development of the weapon system of the Russian Federation Land forces for the period to 2025». One of the purposes of this subprogram is to reduce the period of training of formations and military units of the Land forces to the required level with the help of computer-based forms of training. Th e conducted research is aimed at the solution of the problem of the accelerated education of military specialists and at the improvement of the quality of adaptation of new arms and equipment of RChB defence. Th e purpose of our study is to develop the proposals for the improvement of the organization of combat training by the introduction of interactive teaching computer programs into the system of technical means of training in the educational centers, military units of RChB defence, as well as into the computer work-stations of the special vehicles. Th e research uses dialectical, informational, analytical and logical methods, a complex of pedagogical and psychological methods, as well as methods of visualization of colormaterials and interactive learning. We propose the concept of an interactive teaching computerprogram, which allows to increase the intensity of training of RChB defence troops personell
任何武器系统的发展都是通过将新技术应用到军事装备中来实现的。适应的复杂性和高成本要求在减少物质和财政成本的同时,增加人员培训的强度。在这方面,一项紧迫的任务是通过制订训练设施制度,为大规模训练军事专家创造条件,使受训人员能够更快地掌握维护和战斗使用武器和辐射、化学和生物防御设备的适当技能。为了解决这一问题,在“至2025年俄罗斯联邦陆军武器系统发展”的跨部门复杂目标计划框架内制定了培训技术手段系统发展的子计划。本次级方案的目的之一是利用以计算机为基础的训练形式,将陆军各编队和军事单位的训练时间缩短到所需的水平。所进行的研究旨在解决军事专家的加速教育问题,提高俄军国防新武器装备的适应质量。本研究的目的是通过将交互式计算机教学程序引入国防教育中心、军事单位的技术训练手段系统以及特种车辆的计算机工作站,提出改进作战训练组织的建议。该研究运用了辩证、信息、分析和逻辑的方法,综合运用了教学和心理学的方法,以及彩色材料可视化和互动学习的方法。我们提出了交互式教学计算机程序的概念,这可以增加RChB国防部队人员的训练强度
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引用次数: 0
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Journal of NBC Protection Corps
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