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Antagonism of acute copper(II)-induced renal lesions by sodium 2,3-dimercaptopropanesulfonate. 2,3-二巯基丙磺酸钠拮抗急性铜(II)诱导的肾损害。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
W M Mitchell, M A Basinger, M M Jones

Acute copper(II) sulfate poisoning in the mouse induces renal tubular degeneration and necrosis. Timely administration of sodium 2,3-dimercaptopropane-sulfonate (DMPS) effectively prevented the development of the morphological renal sequelae of copper intoxication. During the time course of this study (5 days), no copper-induced hepatic lesions were observed. DMPS and its preformed copper complex possess low inherent toxicity with no hepatorenal lesions occurring over a 5-day period. These findings suggest that DMPS may be an effective antidote in acute and chronic copper poisoning in humans.

急性硫酸铜中毒小鼠可引起肾小管变性和坏死。及时给药2,3-二巯基丙烷磺酸钠(DMPS)可有效预防铜中毒肾形态后遗症的发生。在研究期间(5天)，未观察到铜诱导的肝脏病变。DMPS及其预成型铜配合物具有低固有毒性，5天内不发生肝肾损害。这些发现表明，DMPS可能是人类急性和慢性铜中毒的有效解毒剂。
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引用次数: 0
Juvenile rheumatoid arthritis. 幼年类风湿性关节炎。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
F C Arnett, L E Widman, R S Feinstein
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引用次数: 0
This is the final issue of The Johns Hopkins Medical Journal. 这是约翰·霍普金斯医学杂志的最后一期。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
S Boyer
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引用次数: 0
Fetal mortality associated with cleft lip and cleft palate. 唇腭裂与胎儿死亡率的关系。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
K R Dronamraju, D Bixler, P P Majumder

Analysis of 1,516 pregnancies in sibships of probands with cleft lip with or without cleft palate [CL(P)], and 774 pregnancies in those of probands with isolated cleft palate (CP) indicated that fetal mortality significantly increases with liability to clefting. These data are compatible with the multifactorial two-threshold model, according to which a lower threshold level of liability results in a cleft formation whereas a higher level of liability causes a fetal death.

对1516例唇裂伴或不伴腭裂的先证姐妹妊娠和774例孤立性腭裂(CP)先证姐妹妊娠的分析表明，随着唇裂倾向的增加，胎儿死亡率显著增加。这些数据与多因素双阈值模型相一致，根据该模型，较低的责任阈值水平导致唇裂形成，而较高的责任阈值水平导致胎儿死亡。
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引用次数: 0
The Rieger syndrome: a heritable disorder associated with glaucoma. 里格尔综合征:一种与青光眼相关的遗传性疾病。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
J R Heckenlively, S J Isenberg, L E Fox
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引用次数: 0
Torsion dystonia. 扭转肌张力障碍。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
R C Wachtel, M L Batshaw, R Eldridge, W Jankel, M Cataldo
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引用次数: 0
Social ramifications of control of microbial disease. 微生物疾病控制的社会后果。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
W McDermott, D E Rogers
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引用次数: 0
Cerebro-hepato-renal (Zellweger) syndrome and neonatal adrenoleukodystrophy: similarities in phenotype and accumulation of very long chain fatty acids. 脑-肝-肾(齐薇格)综合征和新生儿肾上腺白质营养不良:表型和长链脂肪酸积累的相似性。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
F R Brown, A J McAdams, J W Cummins, R Konkol, I Singh, A B Moser, H W Moser
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引用次数: 0
Hepatitis prophylaxis. 肝炎预防。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
R D Aach
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引用次数: 0
Presence of fungiform papillae in classic dysautonomia. 典型自主神经异常中真菌状乳头的存在。
The Johns Hopkins medical journal
Pub Date : 1982-12-01
N Gadoth, D Margalith, N Schlien, E Svetliza, A Litwin

Lack of fungiform papillae over the surface of the tongue is considered essential for the diagnosis of familial dysautonomia. We describe two cases with dysautonomia in which the diagnosis was delayed because numerous fungiform papillae were easily seen. Only a close inspection of the tongue with an ophthalmologic slit lamp revealed that each papilla was degenerated and atrophic. Lacking a clinical sine qua non or easily available diagnostic laboratory tests, fungiform papillae should be studied in detail to establish not only that their number is sufficient but also that their shape and structure are normal. The simple technique described enables confirmation of the diagnosis in children and newborns in whom familial dysautonomia is suspected.

舌表面缺乏真菌状乳头被认为是诊断家族性自主神经异常的必要条件。我们描述了两个病例与自主神经异常，其中诊断延迟，因为许多真菌状乳头很容易看到。只有用眼科裂隙灯仔细检查舌头，才发现每个乳头都退化和萎缩。由于缺乏临床必要条件或容易获得的诊断实验室检查，应详细研究真菌状乳头，不仅确定其数量充足，而且确定其形状和结构是否正常。所描述的简单技术能够在怀疑家族性自主神经异常的儿童和新生儿中确认诊断。
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引用次数: 0
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