首页 > 最新文献

The Johns Hopkins medical journal最新文献

英文 中文
Clinical conferences at The Johns Hopkins Hospital: Kaposi's sarcoma. 约翰霍普金斯医院的临床会议:卡波西肉瘤。
The Johns Hopkins medical journal
Pub Date : 1982-11-01
A F Hood, E R Farmer, R A Weiss

Kaposi's sarcoma is a multifocal neoplasm of the reticuloendothelial system which has generated great interest recently because of its association with immunosuppressive therapy and its occurrence within a group of homosexual men. Our case demonstrates a relationship between the discontinuation of immunosuppressive therapy and tumor regression in a renal transplant recipient. The clustering of cases in geographic areas and within ethnic groups implies that both heriditary and environmental factors contribute to the pathogenesis of this tumor. Recently described cases have occurred in a setting of multiple infections and concurrent impairment of cell mediated immunity. This suggests that Kaposi's sarcoma may be a model of chronic antigen stimulation leading to decreased immune responsiveness and subsequent unchecked growth of transformed cells.

卡波西肉瘤是一种网状内皮系统的多灶性肿瘤，由于其与免疫抑制治疗的关系以及在同性恋男性群体中的发生，最近引起了人们的极大兴趣。我们的病例证明了停止免疫抑制治疗与肾移植受者肿瘤消退之间的关系。在地理区域和种族群体内聚集的病例表明，遗传和环境因素都有助于这种肿瘤的发病机制。最近描述的病例发生在多重感染和细胞介导免疫同时受损的情况下。这表明卡波西肉瘤可能是慢性抗原刺激导致免疫反应性下降和随后转化细胞不受控制生长的模型。
{"title":"Clinical conferences at The Johns Hopkins Hospital: Kaposi's sarcoma.","authors":"A F Hood,&nbsp;E R Farmer,&nbsp;R A Weiss","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kaposi's sarcoma is a multifocal neoplasm of the reticuloendothelial system which has generated great interest recently because of its association with immunosuppressive therapy and its occurrence within a group of homosexual men. Our case demonstrates a relationship between the discontinuation of immunosuppressive therapy and tumor regression in a renal transplant recipient. The clustering of cases in geographic areas and within ethnic groups implies that both heriditary and environmental factors contribute to the pathogenesis of this tumor. Recently described cases have occurred in a setting of multiple infections and concurrent impairment of cell mediated immunity. This suggests that Kaposi's sarcoma may be a model of chronic antigen stimulation leading to decreased immune responsiveness and subsequent unchecked growth of transformed cells.</p>","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 5","pages":"222-30"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17807335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectosigmoidal adenocarcinoma after successful pull-through for imperforate anus and rectourethral fistula: a footnote to Dr. Hugh Young's 1933 operation. 直肠乙状结肠腺癌后成功拉通肛门闭锁和直肠尿道瘘:对休·杨医生1933年手术的脚注。
The Johns Hopkins medical journal
Pub Date : 1982-10-01
H C Polk, J P Welch, H S Nagaraj, M Amin
{"title":"Rectosigmoidal adenocarcinoma after successful pull-through for imperforate anus and rectourethral fistula: a footnote to Dr. Hugh Young's 1933 operation.","authors":"H C Polk,&nbsp;J P Welch,&nbsp;H S Nagaraj,&nbsp;M Amin","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"151-4"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenoleukodystrophy: effects of dietary restriction of very long chain fatty acids and of administration of carnitine and clofibrate on clinical status and plasma fatty acids. 肾上腺脑白质营养不良:饮食限制长链脂肪酸和给予肉碱和氯贝特对临床状态和血浆脂肪酸的影响。
The Johns Hopkins medical journal
Pub Date : 1982-10-01
F R Brown, M A Van Duyn, A B Moser, J D Schulman, W B Rizzo, R D Snyder, J V Murphy, S Kamoshita, C J Migeon, H W Moser
{"title":"Adrenoleukodystrophy: effects of dietary restriction of very long chain fatty acids and of administration of carnitine and clofibrate on clinical status and plasma fatty acids.","authors":"F R Brown,&nbsp;M A Van Duyn,&nbsp;A B Moser,&nbsp;J D Schulman,&nbsp;W B Rizzo,&nbsp;R D Snyder,&nbsp;J V Murphy,&nbsp;S Kamoshita,&nbsp;C J Migeon,&nbsp;H W Moser","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"164-72"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The patient as partner: ethics in clinical oncology research. 病人作为伙伴:临床肿瘤学研究中的伦理学。
The Johns Hopkins medical journal
Pub Date : 1982-10-01
R M Veatch
{"title":"The patient as partner: ethics in clinical oncology research.","authors":"R M Veatch","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"155-61"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colitic arthritis. Colitic关节炎。
The Johns Hopkins medical journal
Pub Date : 1982-10-01
M C Hochberg, R S Feinstein, R L Moser, M J Ryan
{"title":"Colitic arthritis.","authors":"M C Hochberg,&nbsp;R S Feinstein,&nbsp;R L Moser,&nbsp;M J Ryan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"173-80"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hallucinations and delusions following a right temporoparietooccipital infarction. 右颞顶枕骨梗死后的幻觉和妄想。
The Johns Hopkins medical journal
Pub Date : 1982-10-01
S J Peroutka, B H Sohmer, A J Kumar, M Folstein, R G Robinson
{"title":"Hallucinations and delusions following a right temporoparietooccipital infarction.","authors":"S J Peroutka,&nbsp;B H Sohmer,&nbsp;A J Kumar,&nbsp;M Folstein,&nbsp;R G Robinson","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"181-5"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disability from aminoglycoside-induced vestibular paralysis. 氨基糖苷引起的前庭麻痹致残。
The Johns Hopkins medical journal
Pub Date : 1982-10-01
L R Proctor
{"title":"Disability from aminoglycoside-induced vestibular paralysis.","authors":"L R Proctor","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 4","pages":"162-3"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18137028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mannosidosis in an adult. 成人甘露甘露病。
The Johns Hopkins medical journal
Pub Date : 1982-09-01
T R Montgomery, G H Thomas, D L Valle
{"title":"Mannosidosis in an adult.","authors":"T R Montgomery,&nbsp;G H Thomas,&nbsp;D L Valle","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":" ","pages":"113-21"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40724617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pseudohypoparathyroidism. 假性甲状旁腺功能减退症。
The Johns Hopkins medical journal
Pub Date : 1982-09-01

The current understanding of the adenylate cyclase complex has permitted us to regard PHP has a heterogeneous group of disorders related to each other through the common feature of resistance to PTH. Patients may present with hormone resistance limited to PTH, or with a metabolic disorder attributable to the resistance of multiple tissues to hormones that activate adenylate cyclase. The majority of the latter patients show deficient G-unit activity. The clinical expression of multiple hormone resistance in patients with the G-unit defect appears to be rather variable, despite an identical quantitative defect; hormone resistance seems incomplete, and patients may be hypocalcemic despite the presence of hyperparathyroid bone disease. It is therefore likely that the detailed biochemical study of patients with PHP may ultimately reveal a multiplicity of abnormalities in the hormone-receptor adenylate cyclase system that will explain the variability of hormone resistance.

目前对腺苷酸环化酶复合物的了解使我们认为PHP具有异质性的疾病组，通过对甲状旁腺激素的抗性的共同特征相互关联。患者可能表现为局限于甲状旁腺激素的激素抵抗，或者由于多种组织对激活腺苷酸环化酶的激素的抵抗而出现代谢紊乱。后一种患者多数表现为g单位活性不足。g单位缺陷患者的多种激素抵抗的临床表现似乎是相当可变的，尽管有相同的数量缺陷;激素抵抗似乎不完全，尽管存在甲状旁腺功能亢进骨病，患者仍可能出现低钙血症。因此，对PHP患者的详细生化研究可能最终揭示激素受体腺苷酸环化酶系统的多种异常，这将解释激素耐药性的变异性。
{"title":"Pseudohypoparathyroidism.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The current understanding of the adenylate cyclase complex has permitted us to regard PHP has a heterogeneous group of disorders related to each other through the common feature of resistance to PTH. Patients may present with hormone resistance limited to PTH, or with a metabolic disorder attributable to the resistance of multiple tissues to hormones that activate adenylate cyclase. The majority of the latter patients show deficient G-unit activity. The clinical expression of multiple hormone resistance in patients with the G-unit defect appears to be rather variable, despite an identical quantitative defect; hormone resistance seems incomplete, and patients may be hypocalcemic despite the presence of hyperparathyroid bone disease. It is therefore likely that the detailed biochemical study of patients with PHP may ultimately reveal a multiplicity of abnormalities in the hormone-receptor adenylate cyclase system that will explain the variability of hormone resistance.</p>","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 3","pages":"137-46"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17349046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sperm nuclear packing and regulation during spermatogenesis and fertilization. 精子发生和受精过程中精子核的包装和调控。
The Johns Hopkins medical journal
Pub Date : 1982-09-01
B R Zirkin, D A Soucek, T S Chang
{"title":"Sperm nuclear packing and regulation during spermatogenesis and fertilization.","authors":"B R Zirkin,&nbsp;D A Soucek,&nbsp;T S Chang","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":22609,"journal":{"name":"The Johns Hopkins medical journal","volume":"151 3","pages":"101-12"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17862607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
类型
全部 化学•材料 生命科学 医学 物理 工程技术 环境•农林 材料科学 地球科学 法学 管理学 化学 环境科学与生态学 计算机科学 教育学 经济学 农林科学 人文科学 生物学 数学 物理与天体物理 心理学 综合性期刊 其他 工业工程 理学 历史学 农学 文学 信息工程
数据库
全部 ACS Publications Elsevier ieeexplore Springer The Royal Society of Chemistry Wiley
期刊
The Johns Hopkins medical journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
﹀
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们：info@booksci.cn
Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1