U. Lototska-Dudyk, B. Kuzminov, Lyubov Gutor, Оleksandra Breidak, Oksana Kovalska
Introduction. The presence of a connection of metabolic syndrome (MetS) with working conditions in various professional groups dictates the necessity to use diagnostics of its presymptomatic phase in the practice of occupational medicine. The aim was to analyze the indices of anthropometric screening and blood lipid spectre among footwear industry workers with the aim of detecting early metabolic disorders.. Methods. It was conducted a cross-sectional study of 200 footwear industry workers: 119 male (59.5%) and 81 female (40.5%) aged 25 to 62. All workers were divided into groups according to their professional working experience: under 5 years, 6-14 years, 15-21 years.Anthropometric profile indexes were determined: body height (BH), body weight (BW), waist circumference (WC) and hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR). Biochemical indicators of the lipid body balance were assessed by total cholesterol (TCH), triglycerides (TG), high density lipoprotein cholesterol (HDL CH), low density lipoprotein cholesterol (LDL CH), atherogenic coefficient (AC). Results: Visceral obesity was detected among 60.56% of female workers and 30.91% male workers. It has been found that the increasing tendency of WHR was associated with the increase of working experience. The share of workers with normal body weight according to BMI accounts for 39.7-41.18%. Lipid metabolism indices among workers with working experience under 5 years do not differ from referent norm and are characterized as dyslipidemia in the experience group of 15-21 years. The signs of MetS development were detected in 5.0-5.26% (experience group under 5 years), 10.7-11.1% (6-14 years), and 23.5-31.8% (15-21 years) of footwear industry workers. It was higher in male workers (18.3%), than female (11.7%). Conclusions. Professional factors in footwear industry increase the risk of developing MetS components. Inclusion of anthropometric and lipid statuses assessments into the monitoring of health state will help to detect individuals with early dysmetabolic disturbances and to develop preventive instruments directed at saving metabolic health of workers in the branch.
{"title":"BIOMETRIC AND BIOCHEMICAL INDICATORS AS FACTORS OF METABOLIC RISK AMONG FOOTWEAR INDUSTRY WORKERS: THE RELATIONSHIP WITH WORK CONDITIONS","authors":"U. Lototska-Dudyk, B. Kuzminov, Lyubov Gutor, Оleksandra Breidak, Oksana Kovalska","doi":"10.25040/ntsh2022.02.13","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.13","url":null,"abstract":"Introduction. The presence of a connection of metabolic syndrome (MetS) with working conditions in various professional groups dictates the necessity to use diagnostics of its presymptomatic phase in the practice of occupational medicine. \u0000The aim was to analyze the indices of anthropometric screening and blood lipid spectre among footwear industry workers with the aim of detecting early metabolic disorders.. \u0000Methods. It was conducted a cross-sectional study of 200 footwear industry workers: 119 male (59.5%) and 81 female (40.5%) aged 25 to 62. All workers were divided into groups according to their professional working experience: under 5 years, 6-14 years, 15-21 years.Anthropometric profile indexes were determined: body height (BH), body weight (BW), waist circumference (WC) and hip circumference (HC), body mass index (BMI), waist-to-hip ratio (WHR). Biochemical indicators of the lipid body balance were assessed by total cholesterol (TCH), triglycerides (TG), high density lipoprotein cholesterol (HDL CH), low density lipoprotein cholesterol (LDL CH), atherogenic coefficient (AC). \u0000Results: Visceral obesity was detected among 60.56% of female workers and 30.91% male workers. It has been found that the increasing tendency of WHR was associated with the increase of working experience. The share of workers with normal body weight according to BMI accounts for 39.7-41.18%. \u0000Lipid metabolism indices among workers with working experience under 5 years do not differ from referent norm and are characterized as dyslipidemia in the experience group of 15-21 years. The signs of MetS development were detected in 5.0-5.26% (experience group under 5 years), 10.7-11.1% (6-14 years), and 23.5-31.8% (15-21 years) of footwear industry workers. It was higher in male workers (18.3%), than female (11.7%). \u0000Conclusions. Professional factors in footwear industry increase the risk of developing MetS components. Inclusion of anthropometric and lipid statuses assessments into the monitoring of health state will help to detect individuals with early dysmetabolic disturbances and to develop preventive instruments directed at saving metabolic health of workers in the branch.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129117889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Hnateiko, N. Kitsera, S. Henyk-Berezovska, N. Lukyanenko, Nataliya Hruzyntseva
Introduction. The frequency of children with birth defects (BD) according to the WHO reaches 4-6% of the total number of newborns. Objectives. The purpose of this work was to determine the probable risk factors for “model” BDs in newborns. Methods. Analysis of clinical-epidemiological and medical-statistic data from the primary documentation on newborns in 2002-2020 with BDs by the “case-control” method filling out registration cards in maternity hospitals of Lviv region was conducted. Results. There were filled 1204 healthy newborns’ cards and 1211 cards of newborns with BDs. In the structure of “model” BD, the deformations of the musculoskeletal system composed 272 (22.5%) cases, clefts of the lip and palate accounted for 193 (15.9%) cases, chromosomal abnormalities comprised 174 (14.4%) cases. We observed statistically significant risk (р<0.05) of BDs for newborns with increased numbers of pregnancies in mothers. There was a statistically significant difference [OR=3.97; 95%CI: 1.97; 7.99] in the medical history relative to stillbirths (3.2%) in mothers with BD newborns as compared to women in the control group (0.8%). The prevalence of pathological structure of the placenta in women of the study group (32.8%) was higher [OR=3.71; 95%CI:3.01; 4.56] than in those of the control group (16.8%). Mothers of both groups showed no statistically significant difference in anemia, preeclampsia, the interval between pregnancies, and the number of abortions and miscarriages (p> 0.05). Conclusions. Further research in this area should be directed to determine the contributions of genetic factors in BD occurrence, considering the genealogical history of each family.
{"title":"ASSESSMENT OF RISK FACTORS FOR DEVELOPMENT OF BIRTH DEFECTS AMONG NEWBORNS IN LVIV REGION IN 2002-2020 (PART 1)","authors":"O. Hnateiko, N. Kitsera, S. Henyk-Berezovska, N. Lukyanenko, Nataliya Hruzyntseva","doi":"10.25040/ntsh2022.02.15","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.15","url":null,"abstract":"Introduction. The frequency of children with birth defects (BD) according to the WHO reaches 4-6% of the total number of newborns. \u0000Objectives. The purpose of this work was to determine the probable risk factors for “model” BDs in newborns. \u0000Methods. Analysis of clinical-epidemiological and medical-statistic data from the primary documentation on newborns in 2002-2020 with BDs by the “case-control” method filling out registration cards in maternity hospitals of Lviv region was conducted. \u0000Results. There were filled 1204 healthy newborns’ cards and 1211 cards of newborns with BDs. In the structure of “model” BD, the deformations of the musculoskeletal system composed 272 (22.5%) cases, clefts of the lip and palate accounted for 193 (15.9%) cases, chromosomal abnormalities comprised 174 (14.4%) cases. We observed statistically significant risk (р<0.05) of BDs for newborns with increased numbers of pregnancies in mothers. There was a statistically significant difference [OR=3.97; 95%CI: 1.97; 7.99] in the medical history relative to stillbirths (3.2%) in mothers with BD newborns as compared to women in the control group (0.8%). The prevalence of pathological structure of the placenta in women of the study group (32.8%) was higher [OR=3.71; 95%CI:3.01; 4.56] than in those of the control group (16.8%). \u0000Mothers of both groups showed no statistically significant difference in anemia, preeclampsia, the interval between pregnancies, and the number of abortions and miscarriages (p> 0.05). \u0000Conclusions. Further research in this area should be directed to determine the contributions of genetic factors in BD occurrence, considering the genealogical history of each family.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124982433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The article provides a brief description of the heroic work of Ukrainian physicians- volunteers, including allergists, during Russia's brutal war against Ukraine. Examples of the evacuation of Ukrainian residents, including patients with bronchial asthma, respiratory allergies, COVID-19 and other diseases that worsened under the influence of stress, are given. It is briefly described about the destroyed hospitals throughout the territory of Ukraine. In such a critical situation, Ukrainian doctors continue to provide assistance to patients, improve their scientific level, each in his place does everything to Victory. The light will defeat the darkness!
{"title":"THE WORK OF AN ALLERGIST AND SCIENTIST DURING THE FULL-SCALE WAR IN UKRAINE","authors":"S. Zubchenko","doi":"10.25040/ntsh2022.02.18","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.18","url":null,"abstract":"The article provides a brief description of the heroic work of Ukrainian physicians- volunteers, including allergists, during Russia's brutal war against Ukraine. Examples of the evacuation of Ukrainian residents, including patients with bronchial asthma, respiratory allergies, COVID-19 and other diseases that worsened under the influence of stress, are given. It is briefly described about the destroyed hospitals throughout the territory of Ukraine. In such a critical situation, Ukrainian doctors continue to provide assistance to patients, improve their scientific level, each in his place does everything to Victory. The light will defeat the darkness!","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133894701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dear Reader! Today marked the 299th day of the war for the independence of Ukraine. Besides the Armed Forces of Ukraine, the frontline of our battle against the aggressor is being held by healthcare professionals whose selfless work saves lives and the health of patients and ensures the existence of Ukraine. From now on, along with experimental and clinical medicine, there is war medicine in Ukraine, and the entire world is fascinated by its results. NATO Parliamentary Assembly has recently recognized our enemy as a terrorist state and called for creating a specialized international tribunal to punish all criminals. However, the full-scale invasion of the enemy with air raid alerts, shelling, scheduled and emergency blackouts did not stop Ukrainians in their love for education, scientific and research work, and awareness-raising activities. The words once uttered by great Ukrainian Hryhoriy Skovoroda, whose 300th anniversary we are celebrating this year, “The one who thinks of science, loves it, and the one who loves it, will never stop learning, no matter how passive he might seem”, are now more levant than ever. After all, they represent Ukrainian healthcare professionals and scientists. Progressive colleagues from across the globe – people of all races, all ages, ethnicities and religious orientations stand in solidarity with them. Together, they use all available possibilities and talents to bring victory closer and strengthen the positive image of Ukraine in the world. At this time the war situation is complex, with a labile standstill at the front in the east of Ukraine. Meanwhile is it an established fact that an independent Ukraine will continue to exist. Nevertheless, the loss of human lives and the destruction of society and infrastructure continues. Ukraine has shown an exceptional brave perseverance and strength. Now it is time to move forward with wise policies. Life must have to return to normal, without serious threats of war attacks. People have to build up Ukraine and healthcare professionals and scientists need to go back to their regular work finding improvements in daily living for the population. Our journal has a dual mission: 1) to enshrine the confident and attractive image of the journal, which is read in 154 countries of the world, in Ukraine and on the scientific map of the world; and 2) to unite progressive medical communities to share experiences and help Ukraine in the time of war. We would like to extend our sincere gratitude to members of the editorial board, who helped in the making of the journal in 2019-2020. Proudly and confidently, we present our readers with a new issue of our journal. This issue saw the light of day thanks to the extraordinary efforts and incredible responsibility of our authors, reviewers, and editors. Review the detailed report on the 6th International Symposium SMARTLION 2022. Medicine and War, which gathered participating lecturers not just from Ukraine, but also the USA, Germany, F
{"title":"SCIENCE IS THE WEAPON FOR THE FUTURE OF UKRAINE","authors":"Oksana Zayachkivska, A. Coenen","doi":"10.25040/ntsh2022.02.05","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.05","url":null,"abstract":"Dear Reader! \u0000Today marked the 299th day of the war for the independence of Ukraine. Besides the Armed Forces of Ukraine, the frontline of our battle against the aggressor is being held by healthcare professionals whose selfless work saves lives and the health of patients and ensures the existence of Ukraine. From now on, along with experimental and clinical medicine, there is war medicine in Ukraine, and the entire world is fascinated by its results. NATO Parliamentary Assembly has recently recognized our enemy as a terrorist state and called for creating a specialized international tribunal to punish all criminals. However, the full-scale invasion of the enemy with air raid alerts, shelling, scheduled and emergency blackouts did not stop Ukrainians in their love for education, scientific and research work, and awareness-raising activities. The words once uttered by great Ukrainian Hryhoriy Skovoroda, whose 300th anniversary we are celebrating this year, “The one who thinks of science, loves it, and the one who loves it, will never stop learning, no matter how passive he might seem”, are now more levant than ever. After all, they represent Ukrainian healthcare professionals and scientists. Progressive colleagues from across the globe – people of all races, all ages, ethnicities and religious orientations stand in solidarity with them. Together, they use all available possibilities and talents to bring victory closer and strengthen the positive image of Ukraine in the world. \u0000At this time the war situation is complex, with a labile standstill at the front in the east of Ukraine. Meanwhile is it an established fact that an independent Ukraine will continue to exist. Nevertheless, the loss of human lives and the destruction of society and infrastructure continues. Ukraine has shown an exceptional brave perseverance and strength. Now it is time to move forward with wise policies. Life must have to return to normal, without serious threats of war attacks. People have to build up Ukraine and healthcare professionals and scientists need to go back to their regular work finding improvements in daily living for the population. \u0000Our journal has a dual mission: 1) to enshrine the confident and attractive image of the journal, which is read in 154 countries of the world, in Ukraine and on the scientific map of the world; and 2) to unite progressive medical communities to share experiences and help Ukraine in the time of war. \u0000We would like to extend our sincere gratitude to members of the editorial board, who helped in the making of the journal in 2019-2020. \u0000Proudly and confidently, we present our readers with a new issue of our journal. This issue saw the light of day thanks to the extraordinary efforts and incredible responsibility of our authors, reviewers, and editors. Review the detailed report on the 6th International Symposium SMARTLION 2022. Medicine and War, which gathered participating lecturers not just from Ukraine, but also the USA, Germany, F","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116198566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Prostate cancer (PC) is one of the most common cancers among men over 50. Nowadays in Ukraine, the number of new cases of PC tends to increase according to statistics. Objectives. The aim of the study is to identify the main problems in the life quality of patients with PC (C61) to optimize medical care for them. Methods. The main aspects of the quality of life of PC patients are studied by means of EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. Results. In Ukraine, as of the pre-war period (November 2021 – February 2022), the quality of life of patients with PC amounted to 52.31 on a 100-point scale. The worst indicators within the functional scale QLQ-C30 belonged to the subscale “Role functioning” (65.44). According to the QLQ-C30 symptoms scale, the highest score among the complaints of Ukrainian patients is fatigue (48.58). Given the results of our research on the QLQ-PR25 symptom scale, patients with PC were the most worried about “Urinary symptoms”, with a score of 38.54 out of 100. According to the functional scale QLQ-PR25, the worst indicators were for “Sexual activity”, which is equal to 32.22 points on a 100-point scale. Conclusions. It is important to create socio-psychological support for patients with PC and their families, which will include the development and implementation of standardized psychological care at all stages of diagnosis, treatment and rehabilitation.
{"title":"MEDICAL AND SOCIAL SUBSTANTIATION OF THE PROBLEM OF QUALITY OF LIFE OF PATIENTS WITH PROSTATE CANCER","authors":"V. Zub, O. Tolstanov","doi":"10.25040/ntsh2022.02.11","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.11","url":null,"abstract":"Introduction. Prostate cancer (PC) is one of the most common cancers among men over 50. Nowadays in Ukraine, the number of new cases of PC tends to increase according to statistics. \u0000Objectives. The aim of the study is to identify the main problems in the life quality of patients with PC (C61) to optimize medical care for them. \u0000Methods. The main aspects of the quality of life of PC patients are studied by means of EORTC QLQ-C30 and EORTC QLQ-PR25 questionnaires. \u0000Results. In Ukraine, as of the pre-war period (November 2021 – February 2022), the quality of life of patients with PC amounted to 52.31 on a 100-point scale. The worst indicators within the functional scale QLQ-C30 belonged to the subscale “Role functioning” (65.44). According to the QLQ-C30 symptoms scale, the highest score among the complaints of Ukrainian patients is fatigue (48.58). Given the results of our research on the QLQ-PR25 symptom scale, patients with PC were the most worried about “Urinary symptoms”, with a score of 38.54 out of 100. According to the functional scale QLQ-PR25, the worst indicators were for “Sexual activity”, which is equal to 32.22 points on a 100-point scale. \u0000Conclusions. It is important to create socio-psychological support for patients with PC and their families, which will include the development and implementation of standardized psychological care at all stages of diagnosis, treatment and rehabilitation.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124922673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viktoria Serhiyenko, K. Holzmann, S. Holota, Zenovii Derkach, A. Nersesyan, Stanislav Melnyk, O. Chernysh, O. Yatskevych, M. Mišík, V. Bubalo, O. Strilbytska, B. Vatseba, O. Lushchak, S. Knasmüller, A. Cherkas
Introduction. The incidence of post-traumatic stress disorder (PTSD) is increasing due to war in Ukraine is of growing importance as this disorder is a serious risk factor for alcohol/drug abuse, depression, suicide and functional dysregulation of internal organs, in particular cardiovascular, endocrine, immune systems. PTSD can also lead to social inadaptation in family and at work. This makes PTSD a very important social problem in Ukraine that causes significant economic damage, since most of the PTSD patients are young and in working age. Objectives. The purpose of this paper is to describe the rationale, key elements of design, methodology and future prospects of the ongoing project “Exploratory study of health related physiological and biochemical parameters to identify simple, robust and relevant biomarkers for therapeutic interventions for PTSD patients”. Methods. Short time ECG records (5 minutes in supine position and 6 minutes in orthostatic test) recorded by “CARDIOLAB” (Kharkiv, Ukraine) digital ECG device with software to analyze HRV was used to calculate time-domain and frequency-domain parameters of HRV. Results. The pattern of HRV changes indicates suppression of parasympathetic activity, low overall spectral power and dominance of sympathetic branch of autonomic nervous system in participants with PTSD. Conclusions. PTSD has no effective treatment so far and the best clinical practices rarely reach efficacy of 50%. The realization of the exploratory clinical study described in this paper will provide insights in the mechanisms underlying systemic consequences of PTSD and will build the evidence enabling clinical trial(s) for studying treatment intervention for patients with PTSD.
{"title":"AN EXPLORATORY STUDY OF PHYSIOLOGICAL AND BIOCHEMICAL PARAMETERS TO IDENTIFY SIMPLE, ROBUST AND RELEVANT BIOMARKERS FOR THERAPEUTIC INTERVENTIONS FOR PTSD: STUDY RATIONALE, KEY ELEMENTS OF DESIGN AND A CONTEXT OF WAR IN UKRAINE","authors":"Viktoria Serhiyenko, K. Holzmann, S. Holota, Zenovii Derkach, A. Nersesyan, Stanislav Melnyk, O. Chernysh, O. Yatskevych, M. Mišík, V. Bubalo, O. Strilbytska, B. Vatseba, O. Lushchak, S. Knasmüller, A. Cherkas","doi":"10.25040/ntsh2022.02.14","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.14","url":null,"abstract":"Introduction. The incidence of post-traumatic stress disorder (PTSD) is increasing due to war in Ukraine is of growing importance as this disorder is a serious risk factor for alcohol/drug abuse, depression, suicide and functional dysregulation of internal organs, in particular cardiovascular, endocrine, immune systems. PTSD can also lead to social inadaptation in family and at work. This makes PTSD a very important social problem in Ukraine that causes significant economic damage, since most of the PTSD patients are young and in working age. \u0000Objectives. The purpose of this paper is to describe the rationale, key elements of design, methodology and future prospects of the ongoing project “Exploratory study of health related physiological and biochemical parameters to identify simple, robust and relevant biomarkers for therapeutic interventions for PTSD patients”. \u0000Methods. Short time ECG records (5 minutes in supine position and 6 minutes in orthostatic test) recorded by “CARDIOLAB” (Kharkiv, Ukraine) digital ECG device with software to analyze HRV was used to calculate time-domain and frequency-domain parameters of HRV. \u0000Results. The pattern of HRV changes indicates suppression of parasympathetic activity, low overall spectral power and dominance of sympathetic branch of autonomic nervous system in participants with PTSD. \u0000Conclusions. PTSD has no effective treatment so far and the best clinical practices rarely reach efficacy of 50%. The realization of the exploratory clinical study described in this paper will provide insights in the mechanisms underlying systemic consequences of PTSD and will build the evidence enabling clinical trial(s) for studying treatment intervention for patients with PTSD.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114344069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Orlyk, B. Kondratskyi, Mariya Vynarchyk, Sofia Prymak, Halyna Savuliak, Vasyl Novak
Introduction. In modern transfusion practice, both in peacetime and in military conditions, red blood cells (RBCs) are widely used as the main component of donor blood. Cryopreserved red blood cells are considered the most safe and high-quality RBC-containing environment. However, the storage period of thawed RBCs after cryopreservation is limited to 24 hours, and significantly complicates their use. Therefore, extending the storage period of thawed RBCs is relevant for the blood service. Research objective: study the RBCs morphological state and functional completeness that were cryopreserved at -40ºС and stored for 7 days at a temperature of +2ºС - +4ºС after thawing. Materials and methods. The object of the study were RBCs that were cryopreserved at -40ºС and stored for 7 days at a temperature of +2ºС - +4ºС after thawing. Deglycerolization of the thawed red blood cells, cryopreserved at -40ºС, required three time washing by using reverse cytoagglomeration. Thawed RBCs were re-suspended in lactate-sucrose-phosphate solution. After RBC thawing and storage for 7 days (186 doses) in the suspension the following indicators were studied: free hemoglobin, extracellular potassium, adenosine triphosphoric acid (ATP), 2,3-diphosphoglycerate (2,3-DPG), hematocrit, degree of hemoglobin affinity to oxygen (P50,), viscosity coefficient, osmotic stability, electrophoretic mobility of erythrocytes. as well as the total number of cells lost and recovered. Results. After storage for 7 days of suspension of thawed RBCs at a temperature of +2ºС - +4ºС indicators of free hemoglobin (0,62±0,02 g/l), extracellular potassium (2,7±0,3 mmol/l), hematocrit (0,4±0,02 l/l) were within normal limits. Osmotic resistance (0,46±0,02%), electrophoretic mobility (0,94±0,04 µm·cm·V-1·s-1) of RBCs, suspension viscosity factor (5,5±0,20mPa·С) did not exhibit changes in comparison with normal values. High levels of ATP indicators (3,0±0,2 µmol/gHb) and 2,3-DPG (10,5±1,3 µmol/gHb) were established. Indicator Р50 (24,1±1,3 hPa) corresponded to low hemoglobine affinity for oxygen. After 7-day storage at +2ºС - +4ºС total cell loss was insignificant and amounted to 5,6±0,4%. High percentage of viable thawed RBCs 94,4±0,5% was shown. Conclusions. Deglycerolization of thawed red blood cells, cryopreserved at -40ºС, by reverse cytoagglomeration, as well as use of lactate-sucrose-phosphate solution for washed RBCs resuspending promote prolongation of thawed RBCs storage period up to 7 days at +2ºС - +4ºС in viable condition.
{"title":"PROLONGED STORAGE OF THAWED RED BLOOD CELLS","authors":"V. Orlyk, B. Kondratskyi, Mariya Vynarchyk, Sofia Prymak, Halyna Savuliak, Vasyl Novak","doi":"10.25040/ntsh2022.02.10","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.10","url":null,"abstract":"Introduction. In modern transfusion practice, both in peacetime and in military conditions, red blood cells (RBCs) are widely used as the main component of donor blood. Cryopreserved red blood cells are considered the most safe and high-quality RBC-containing environment. However, the storage period of thawed RBCs after cryopreservation is limited to 24 hours, and significantly complicates their use. Therefore, extending the storage period of thawed RBCs is relevant for the blood service. Research objective: study the RBCs morphological state and functional completeness that were cryopreserved at -40ºС and stored for 7 days at a temperature of +2ºС - +4ºС after thawing. \u0000Materials and methods. The object of the study were RBCs that were cryopreserved at -40ºС and stored for 7 days at a temperature of +2ºС - +4ºС after thawing. Deglycerolization of the thawed red blood cells, cryopreserved at -40ºС, required three time washing by using reverse cytoagglomeration. Thawed RBCs were re-suspended in lactate-sucrose-phosphate solution. After RBC thawing and storage for 7 days (186 doses) in the suspension the following indicators were studied: free hemoglobin, extracellular potassium, adenosine triphosphoric acid (ATP), 2,3-diphosphoglycerate (2,3-DPG), hematocrit, degree of hemoglobin affinity to oxygen (P50,), viscosity coefficient, osmotic stability, electrophoretic mobility of erythrocytes. as well as the total number of cells lost and recovered. \u0000Results. After storage for 7 days of suspension of thawed RBCs at a temperature of +2ºС - +4ºС indicators of free hemoglobin (0,62±0,02 g/l), extracellular potassium (2,7±0,3 mmol/l), hematocrit (0,4±0,02 l/l) were within normal limits. Osmotic resistance (0,46±0,02%), electrophoretic mobility (0,94±0,04 µm·cm·V-1·s-1) of RBCs, suspension viscosity factor (5,5±0,20mPa·С) did not exhibit changes in comparison with normal values. High levels of ATP indicators (3,0±0,2 µmol/gHb) and 2,3-DPG (10,5±1,3 µmol/gHb) were established. Indicator Р50 (24,1±1,3 hPa) corresponded to low hemoglobine affinity for oxygen. After 7-day storage at +2ºС - +4ºС total cell loss was insignificant and amounted to 5,6±0,4%. High percentage of viable thawed RBCs 94,4±0,5% was shown. \u0000Conclusions. Deglycerolization of thawed red blood cells, cryopreserved at -40ºС, by reverse cytoagglomeration, as well as use of lactate-sucrose-phosphate solution for washed RBCs resuspending promote prolongation of thawed RBCs storage period up to 7 days at +2ºС - +4ºС in viable condition.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"126 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124457474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Being unable to use the usual form of education focused mainly on the teacher, higher education institutions are forced to introduce rules and instructions that would be focused on education seekers and help facilitate the perception of educational material. The consequence of the current situation is the growth of the general interest in distance learning during the pandemic, which later continued during the Russian aggression. In the case of clinical disciplines, certain features determine the use of methods and elements of simulation and individualized training for students of medical faculties, interns and students of the faculty of postgraduate education. Objective. To study the peculiarities of distance learning during the pandemic of acute respiratory disease COVID-19, caused by SARS-CoV-2, and martial law, the identification of the main determinants for the successful arrangement of the online education process. The logical method was used to create instructions for optimizing the conditions and means of learning and teaching. The article reflects the peculiarities of distance learning, introduced during the pandemic and continued under circumstances of martial law caused by the armed aggression of the Russian Federation. Positive aspects of an adequate visual presentation of information during clinical lectures are determined. The results of the survey conducted to determine the attitude of education seekers and scientific and teaching staff to distance learning are presented to identify the shortcomings of this form of education and the development and implementation of Internet resources based on methods and tools that can be used in training to increase the level of student success. Based on its results, the most important features that have the biggest effect on the quality of education were identified.
{"title":"DISTANCE LEARNING EXPERIENCE FOR MEDICAL STUDENTS DURING A PANDEMIC AND MARTIAL LAW","authors":"S. Yagelo, A. Vergun, Halyna Stechak, O. Vergun","doi":"10.25040/ntsh2022.02.19","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.19","url":null,"abstract":"Being unable to use the usual form of education focused mainly on the teacher, higher education institutions are forced to introduce rules and instructions that would be focused on education seekers and help facilitate the perception of educational material. The consequence of the current situation is the growth of the general interest in distance learning during the pandemic, which later continued during the Russian aggression. In the case of clinical disciplines, certain features determine the use of methods and elements of simulation and individualized training for students of medical faculties, interns and students of the faculty of postgraduate education. Objective. To study the peculiarities of distance learning during the pandemic of acute respiratory disease COVID-19, caused by SARS-CoV-2, and martial law, the identification of the main determinants for the successful arrangement of the online education process. The logical method was used to create instructions for optimizing the conditions and means of learning and teaching. The article reflects the peculiarities of distance learning, introduced during the pandemic and continued under circumstances of martial law caused by the armed aggression of the Russian Federation. Positive aspects of an adequate visual presentation of information during clinical lectures are determined. The results of the survey conducted to determine the attitude of education seekers and scientific and teaching staff to distance learning are presented to identify the shortcomings of this form of education and the development and implementation of Internet resources based on methods and tools that can be used in training to increase the level of student success. Based on its results, the most important features that have the biggest effect on the quality of education were identified.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126476381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olga Lapshyna, O. Samchuk, N. Matolinets, T. Keck, Jens Scholz, H. Lapshyn
The key areas of scientific and practical cooperation between the University of Lübeck, the University Clinic of Schleswig-Holstein (Germany), Danylo Halytsky Lviv National Medical University and hospitals of Ukraine are presented. The active position of the University Clinic Schleswig-Holstein (UKSH) made it possible to organize the transfer of significant humanitarian aid to Ukraine during the full-scale invasion of Russia.
{"title":"UNIVERSITY MEDICAL CENTER SCHLESWIG-HOLSTEIN – CONTRIBUTION IN DEVELOPMENT OF UKRAINIAN MEDICINE AND SUPPORT IN THE WAR TIME","authors":"Olga Lapshyna, O. Samchuk, N. Matolinets, T. Keck, Jens Scholz, H. Lapshyn","doi":"10.25040/ntsh2022.02.17","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.17","url":null,"abstract":"The key areas of scientific and practical cooperation between the University of Lübeck, the University Clinic of Schleswig-Holstein (Germany), Danylo Halytsky Lviv National Medical University and hospitals of Ukraine are presented. The active position of the University Clinic Schleswig-Holstein (UKSH) made it possible to organize the transfer of significant humanitarian aid to Ukraine during the full-scale invasion of Russia.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114342680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background. Antimicrobial therapy is a common practice in pediatrics. Aim. The main objective was to determine and characterize the profile of antibiotic prescriptions in pediatric outpatients. Methods. This was a retrospective observational study performed in two pharmacies in Lviv (October 2021). 113 written doctor’s prescriptions for outpatient children were collected. Results. Antibiotics were administered for 44.2% (95%CI 34.9%–53.9%) of patients. The main reasons for antibiotic prescriptions were acute tonsillitis (30.0%) and acute upper respiratory tract infections (26.0%). Macrolides, cephalosporins, penicillins, and sulfonamides with trimethoprim presented 40.0%, 36.0%, 20.0%, and 4.0% of antibiotic prescriptions, respectively. Antimicrobials from the Access group accounted for 26.0% of antibiotic prescriptions (instead of at least 60.0%, WHO) and antibiotics from the Watch group constituted 74.0% (instead of a maximum of 40.0%, WHO). Antibiotics were prescribed to 61.9% of outpatients with acute upper respiratory tract infections, 93.7% of patients with acute tonsillitis, and 45.5% – with otitis media instead of recommended 0-20% (ESAC-Net). The first-line antibiotics were used in 23.1% of cases of acute upper respiratory infections, 26.7% of cases of acute tonsillitis, and 40.0% of otitis media, which is below the acceptable range (80–100%, ESAC-Net). In total, 22 antibiotic-associated drug-related problems (DRPs) were found in 34.0% of written doctor’s prescriptions with antimicrobials. The most common were: (1) excessive length of therapy (36.4%) and (2) potential drug-drug interactions (31.8%). Conclusions. The rate of antibiotic prescriptions for children is high and associated with different DRPs. The majority of antibiotic prescription quality indicators are outside the recommended ranges. Thus, effective interventions and campaigns to improve antibiotic therapy in children are needed.
{"title":"THE PROFILE OF ANTIBIOTIC PRESCRIPTIONS IN PEDIATRIC OUTPATIENTS: A RETROSPECTIVE OBSERVATIONAL STUDY","authors":"O. Horodnycha, A. Zimenkovsky","doi":"10.25040/ntsh2022.02.09","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.09","url":null,"abstract":"Background. Antimicrobial therapy is a common practice in pediatrics. \u0000Aim. The main objective was to determine and characterize the profile of antibiotic prescriptions in pediatric outpatients. \u0000Methods. This was a retrospective observational study performed in two pharmacies in Lviv (October 2021). 113 written doctor’s prescriptions for outpatient children were collected. \u0000Results. Antibiotics were administered for 44.2% (95%CI 34.9%–53.9%) of patients. The main reasons for antibiotic prescriptions were acute tonsillitis (30.0%) and acute upper respiratory tract infections (26.0%). Macrolides, cephalosporins, penicillins, and sulfonamides with trimethoprim presented 40.0%, 36.0%, 20.0%, and 4.0% of antibiotic prescriptions, respectively. Antimicrobials from the Access group accounted for 26.0% of antibiotic prescriptions (instead of at least 60.0%, WHO) and antibiotics from the Watch group constituted 74.0% (instead of a maximum of 40.0%, WHO). Antibiotics were prescribed to 61.9% of outpatients with acute upper respiratory tract infections, 93.7% of patients with acute tonsillitis, and 45.5% – with otitis media instead of recommended 0-20% (ESAC-Net). The first-line antibiotics were used in 23.1% of cases of acute upper respiratory infections, 26.7% of cases of acute tonsillitis, and 40.0% of otitis media, which is below the acceptable range (80–100%, ESAC-Net). In total, 22 antibiotic-associated drug-related problems (DRPs) were found in 34.0% of written doctor’s prescriptions with antimicrobials. The most common were: (1) excessive length of therapy (36.4%) and (2) potential drug-drug interactions (31.8%). \u0000Conclusions. The rate of antibiotic prescriptions for children is high and associated with different DRPs. The majority of antibiotic prescription quality indicators are outside the recommended ranges. Thus, effective interventions and campaigns to improve antibiotic therapy in children are needed.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125700022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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