O. Prokopiv, Svitlana Lysheniuk, Lidia Segedii, H. Karmazyn
Meningococcal infection in the form of sporadic cases or minor group outbreaks, mostly among children, is registered in all countries of the world. The disease has a wide range of clinical manifestations – from an asymptomatic bacterial carriage and acute nasopharyngitis to the rapid development of meningococcemia, acute meningococcal sepsis and meningitis. The article highlights and summarizes literature data related to the incidence of meningococcal infection, ways of infection, features of the clinical course of the disease in the newborn period, and modern views on the problem. A rare clinical case of the development of severe generalized forms of meningococcal infection in 3-month-old twins with a fatal outcome in one child is described. The decisive role in the development of the disease of twins is determined by the way and duration of children’s contact with their father, who has a bacteriologically confirmed (Neisseria meningitidis, biovar C) meningococcal nasopharyngitis. Early diagnosis and treatment of all forms of meningococcal infections are important to prevent the development of GMI. The key method of MI prevention is vaccination.
{"title":"MENINGOCOCCAL INFECTION: A BRIEF REVIEW AND PERSONAL OBSERVATIONS OF THE GENERALIZED FORM OF THE DISEASE IN THREE-MONTH-OLD TWINS","authors":"O. Prokopiv, Svitlana Lysheniuk, Lidia Segedii, H. Karmazyn","doi":"10.25040/ntsh2022.02.08","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.08","url":null,"abstract":"Meningococcal infection in the form of sporadic cases or minor group outbreaks, mostly among children, is registered in all countries of the world. The disease has a wide range of clinical manifestations – from an asymptomatic bacterial carriage and acute nasopharyngitis to the rapid development of meningococcemia, acute meningococcal sepsis and meningitis. The article highlights and summarizes literature data related to the incidence of meningococcal infection, ways of infection, features of the clinical course of the disease in the newborn period, and modern views on the problem. A rare clinical case of the development of severe generalized forms of meningococcal infection in 3-month-old twins with a fatal outcome in one child is described. The decisive role in the development of the disease of twins is determined by the way and duration of children’s contact with their father, who has a bacteriologically confirmed (Neisseria meningitidis, biovar C) meningococcal nasopharyngitis. Early diagnosis and treatment of all forms of meningococcal infections are important to prevent the development of GMI. The key method of MI prevention is vaccination.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127822338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Trutyak, D. Los, V. Medzyn, Vasyl Trunkvalter, Volodymyr Zukovsky
Among the total number of wounded who entered the Military Medical Clinical Center of the Western Region from February to September 2022, combat injury to the limbs was in 63.3%. Bullet wounds caused combat injury to the limbs in 10.4%, shrapnel and mine-explosive – in 68.1%, explosive injury – in 21.5%. At the second role of medical care, emergency surgical interventions were performed on the wounded, immobilization of bone fractures with an external fixation and anti-shock therapy. At the third and fourth roles – the treatment of the wounded consisted in the use of a multidisciplinary approach with the involvement of doctors of various specialties, first of all, general surgeons, traumatologists, vascular, plastic surgeons and anesthesiologists. The most frequent surgical intervention was repeatened and secondary debridment of gunshot wounds, which was required by 93% of the wounded. The main pathogens that vegetated in wounds were Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter aerogenes, Proteus vulgaris, Enterococcus faecalis with high levels of microbial contamination – 104-108/g in tissues., Various types of plastics were used to close soft tissue defects, according to the rule of the reconstruction ladder. After healing a soft tissue wound to determine the timing of replacing the method of fixing fractures with internal osteosynthesis, were analyzed clinical and laboratory parameters and assessed the risks of complications. The main causes of amputations of the limbs were common defects in soft tissue and bones, which were not subject to reconstruction with no prognosis for bone fusion and progression of the infectious-necrotic process.
{"title":"TREATMENT OF COMBAT SURGICAL TRAUMA OF THE LIMBS IN THE CONDITIONS OF MODERN WAR","authors":"I. Trutyak, D. Los, V. Medzyn, Vasyl Trunkvalter, Volodymyr Zukovsky","doi":"10.25040/ntsh2022.02.16","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.16","url":null,"abstract":"Among the total number of wounded who entered the Military Medical Clinical Center of the Western Region from February to September 2022, combat injury to the limbs was in 63.3%. Bullet wounds caused combat injury to the limbs in 10.4%, shrapnel and mine-explosive – in 68.1%, explosive injury – in 21.5%. At the second role of medical care, emergency surgical interventions were performed on the wounded, immobilization of bone fractures with an external fixation and anti-shock therapy. At the third and fourth roles – the treatment of the wounded consisted in the use of a multidisciplinary approach with the involvement of doctors of various specialties, first of all, general surgeons, traumatologists, vascular, plastic surgeons and anesthesiologists. The most frequent surgical intervention was repeatened and secondary debridment of gunshot wounds, which was required by 93% of the wounded. The main pathogens that vegetated in wounds were Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter aerogenes, Proteus vulgaris, Enterococcus faecalis with high levels of microbial contamination – 104-108/g in tissues., Various types of plastics were used to close soft tissue defects, according to the rule of the reconstruction ladder. After healing a soft tissue wound to determine the timing of replacing the method of fixing fractures with internal osteosynthesis, were analyzed clinical and laboratory parameters and assessed the risks of complications. The main causes of amputations of the limbs were common defects in soft tissue and bones, which were not subject to reconstruction with no prognosis for bone fusion and progression of the infectious-necrotic process.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126435633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. One of the frequent complications of the type 2 diabetes mellitus (T2DM) is a metabolic-associated fatty liver disease (MAFLD). Aim. To study the composition of gut microbiota in patients with a combination of T2DM and MAFLD and to compare it with the microbiota in isolated T2DM and MAFLD. Methods. 111 patients were studied. The main group consisted of 56 patients with a combination of MAFLD and T2DM; the 1st group included 28 patients with MAFLD and the 2nd - 27 patients with T2DM. The control group consisted of 30 practically healthy people. Diagnosis was made by steatometry, shear wave elastography, lactulose H2 breath test, qPCR of feces using primers targeting the 16S rRNA gene, and stool culture. Results. In the the main group SIBO was found in 48.2%, in 1st – 35.7%, in 2nd – 33.3%, compared to 10% in the control group. When compared with healthy people, the number of "other" microorganisms significantly increased in the group with isolated T2DM and Clostridium, Proteus and Candida were cultured; in the case of isolated MAFLD, a decrease in Bacteroidetes and an increase in the Firmicutes/Bacteroidetes ratio, as well as an increase in Klebsiella and Clostridium. In the main group, an increase in Actinobacteria, "other" microorganisms, a ratio of Firmicutes/Bacteroidetes and a decrease in Bacteroidetes were found, when cultured - an increase in Clostridium, Klebsiella and Candida. Conclusions. Only the group of MAFLD with T2DM was characterized by increased Actinobacteria; decreased absolute number of Bifidobacterium and Lactobacillus and increased Escherichia, including with altered enzymatic properties in the stool culture.
{"title":"STATE OF THE GUT MICROBIOTA IN PATIENTS WITH METABOLIC-ASSOCIATED FATTY LIVER DISEASE WITH TYPE 2 DIABETES MELLITUS","authors":"A. Dorofeyev, Mykola L. Rudenko, Т. Cheverda","doi":"10.25040/ntsh2022.02.12","DOIUrl":"https://doi.org/10.25040/ntsh2022.02.12","url":null,"abstract":"Introduction. One of the frequent complications of the type 2 diabetes mellitus (T2DM) is a metabolic-associated fatty liver disease (MAFLD). Aim. To study the composition of gut microbiota in patients with a combination of T2DM and MAFLD and to compare it with the microbiota in isolated T2DM and MAFLD. \u0000Methods. 111 patients were studied. The main group consisted of 56 patients with a combination of MAFLD and T2DM; the 1st group included 28 patients with MAFLD and the 2nd - 27 patients with T2DM. The control group consisted of 30 practically healthy people. Diagnosis was made by steatometry, shear wave elastography, lactulose H2 breath test, qPCR of feces using primers targeting the 16S rRNA gene, and stool culture. \u0000Results. In the the main group SIBO was found in 48.2%, in 1st – 35.7%, in 2nd – 33.3%, compared to 10% in the control group. When compared with healthy people, the number of \"other\" microorganisms significantly increased in the group with isolated T2DM and Clostridium, Proteus and Candida were cultured; in the case of isolated MAFLD, a decrease in Bacteroidetes and an increase in the Firmicutes/Bacteroidetes ratio, as well as an increase in Klebsiella and Clostridium. In the main group, an increase in Actinobacteria, \"other\" microorganisms, a ratio of Firmicutes/Bacteroidetes and a decrease in Bacteroidetes were found, when cultured - an increase in Clostridium, Klebsiella and Candida. \u0000Conclusions. Only the group of MAFLD with T2DM was characterized by increased Actinobacteria; decreased absolute number of Bifidobacterium and Lactobacillus and increased Escherichia, including with altered enzymatic properties in the stool culture.","PeriodicalId":345961,"journal":{"name":"Proceeding of the Shevchenko Scientific Society. Medical Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130365862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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