Pub Date : 2024-01-01DOI: 10.32598/bcn.2022.4292.1
Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi
{"title":"The Effect of Omega-3 Supplementation on Serum Levels of Antioxidant Status in Patients With Bipolar Disease: A Randomized Double-blind Controlled Clinical Trial","authors":"Dina Gholipour, Mansour Shahraki, Mohsen Saravani, Abolfazl Payandeh, Hadi Eslahi","doi":"10.32598/bcn.2022.4292.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.4292.1","url":null,"abstract":"","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"158 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-29DOI: 10.32598/bcn.2023.5693.1
Seyyed Mohammad Taghi Razavi-Toosi, Yasin Asadi, N. Aboutaleb, Masoumeh Faezi
Introduction: Stem cells isolated from amniotic membrane can produce and freedom substances that have the ability to regenerate damaged tissues and contain proteins and other factors that apply via numerous major and minor mechanisms leading to increasing angiogenesis and tissue survival. The research was conducted to prove the defensive characteristics of the secretome in the face of temporary focal cerebral ischemia in mouse stroke models. Methods: Cerebral ischemia protocol in a specific area was implemented in rats with middle cerebral artery occlusion for 60 minutes and then reperfusion was given for 6, 20 and 30 minutes. Within 30 minutes after the start of reperfusion, conditioned medium derived from human amniotic membrane (AMSC-CM) was poured into the right ventricle (ICV) with a dose of 0.5 microliters. Finally, the volume of the injury, cerebral tissue water, sensorimotor activity and the strength of the blood-brain barrier integrity were evaluated 24 hours after drug injection. Results: ICV injection of conditioned medium at the start of reperfusion phase considerably decrease the volume of the injury in 6, 20, and 30 hours after reperfusion compared MCAO operated group (p < 0.01), cerebral tissue water in the treatment group decreased considerably after intervention in comparison with the MCAO group in core and penumbral area not in the subcortical area (p < 0.05), Also, the Evans Blue penetration rate in all times in the core and penumbral area in AMSC-CM group considerably decreased paralleled with the MCAO group (p < 0.05). Conclusion: The results show that treatment with AMSC-CM during 6-30 h after ischemia-reperfusion insult exerts some beneficial effects against ischemia-reperfusion injury. These findings provide an important vision for more complementary research and treatment of stroke.
{"title":"Conditioned Medium Derived from the Human Amniotic Membrane Prevents Brain Damage against Cerebral Ischemia/Reperfusion in Three Phases, Subacute, Acute, and Chronic in a Stroke Model in Rats","authors":"Seyyed Mohammad Taghi Razavi-Toosi, Yasin Asadi, N. Aboutaleb, Masoumeh Faezi","doi":"10.32598/bcn.2023.5693.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.5693.1","url":null,"abstract":"Introduction: Stem cells isolated from amniotic membrane can produce and freedom substances that have the ability to regenerate damaged tissues and contain proteins and other factors that apply via numerous major and minor mechanisms leading to increasing angiogenesis and tissue survival. The research was conducted to prove the defensive characteristics of the secretome in the face of temporary focal cerebral ischemia in mouse stroke models. Methods: Cerebral ischemia protocol in a specific area was implemented in rats with middle cerebral artery occlusion for 60 minutes and then reperfusion was given for 6, 20 and 30 minutes. Within 30 minutes after the start of reperfusion, conditioned medium derived from human amniotic membrane (AMSC-CM) was poured into the right ventricle (ICV) with a dose of 0.5 microliters. Finally, the volume of the injury, cerebral tissue water, sensorimotor activity and the strength of the blood-brain barrier integrity were evaluated 24 hours after drug injection. Results: ICV injection of conditioned medium at the start of reperfusion phase considerably decrease the volume of the injury in 6, 20, and 30 hours after reperfusion compared MCAO operated group (p < 0.01), cerebral tissue water in the treatment group decreased considerably after intervention in comparison with the MCAO group in core and penumbral area not in the subcortical area (p < 0.05), Also, the Evans Blue penetration rate in all times in the core and penumbral area in AMSC-CM group considerably decreased paralleled with the MCAO group (p < 0.05). Conclusion: The results show that treatment with AMSC-CM during 6-30 h after ischemia-reperfusion insult exerts some beneficial effects against ischemia-reperfusion injury. These findings provide an important vision for more complementary research and treatment of stroke.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139213099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.32598/bcn.2022.2297.1
H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri
Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.
导言：众所周知，甲基苯丙胺（MA）作为一种精神兴奋剂，会导致长期的认知障碍。以往的研究表明，锂作为一种情绪稳定剂，可促进大多数脑部疾病患者的认知能力。本研究探讨了锂对暴露于 METH 的大鼠的空间记忆、海马凋亡和脑水肿的影响。研究方法本研究使用 32 只 Wistar 大鼠来研究锂对 Morris 水迷宫空间记忆、TUNEL 法检测海马凋亡以及 MA 给药后脑水肿的影响。结果研究结果表明，锂治疗能明显改善 MA 治疗大鼠的空间学习和记忆损伤。此外，研究结果表明，锂治疗能明显减轻 MA 暴露大鼠的脑水肿和 CA1 神经元的凋亡。结论研究结果表明，锂能部分改善 MA 诱导的大鼠神经认知缺陷，这可能与锂对海马的保护作用有关。
{"title":"Investigating Facilitatory Effects of Lithium on Methamphetamine-induced Spatial Memory Impairments in Rat","authors":"H. Ghazvini, F. Tirgar, Mehdi Khodamoradi, Seyedeh Masoumeh Seyedhosseini Tamijani, Saba Niknamfar, E. Akbari, Mohammad Nekahi, Nabiollah Tarjani, Hossein Ghalehnoei, Motahareh Rouhi Ardeshiri","doi":"10.32598/bcn.2022.2297.1","DOIUrl":"https://doi.org/10.32598/bcn.2022.2297.1","url":null,"abstract":"Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA –induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-01DOI: 10.32598/bcn.2022.3830.2
Mohammad Saleh Khajeh Hosseini, Mohammad Pourmir Firoozabadi, Kambiz Badie, Parviz Azad Fallah
Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19–30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.
{"title":"Electroencephalograph Emotion Classification Using a Novel Adaptive Ensemble Classifier Considering Personality Traits","authors":"Mohammad Saleh Khajeh Hosseini, Mohammad Pourmir Firoozabadi, Kambiz Badie, Parviz Azad Fallah","doi":"10.32598/bcn.2022.3830.2","DOIUrl":"https://doi.org/10.32598/bcn.2022.3830.2","url":null,"abstract":"Introduction: The study explores the use of Electroencephalograph (EEG) signals as a means to uncover various states of the human brain, with a specific focus on emotion classification. Despite the potential of EEG signals in this domain, existing methods face challenges. Features extracted from EEG signals may not accurately represent an individual's emotional patterns due to interference from time-varying factors and noise. Additionally, higher-level cognitive factors, such as personality, mood, and past experiences, further complicate emotion recognition. The dynamic nature of EEG data in terms of time series introduces variability in feature distribution and interclass discrimination across different time stages. Methods: To address these challenges, the paper proposes a novel adaptive ensemble classification method. The study introduces a new method for providing emotional stimuli, categorizing them into three groups (sadness, neutral, and happiness) based on their valence-arousal (VA) scores. The experiment involved 60 participants aged 19–30 years, and the proposed method aimed to mitigate the limitations associated with conventional classifiers. Results: The results demonstrate a significant improvement in the performance of emotion classifiers compared to conventional methods. The classification accuracy achieved by the proposed adaptive ensemble classification method is reported at 87.96%. This suggests a promising advancement in the ability to accurately classify emotions using EEG signals, overcoming the limitations outlined in the introduction. Conclusion: In conclusion, the paper introduces an innovative approach to emotion classification based on EEG signals, addressing key challenges associated with existing methods. By employing a new adaptive ensemble classification method and refining the process of providing emotional stimuli, the study achieves a noteworthy improvement in classification accuracy. This advancement is crucial for enhancing our understanding of the complexities of emotion recognition through EEG signals, paving the way for more effective applications in fields such as neuroinformatics and affective computing.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139346844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.32598/bcn.2023.4724.1
J. Mehvari, Zeinab Jaafari, Mohamad Zare, N. Tabrizi, Alireza Khosravi Farsani
Introduction: Sudden unexpected death in epilepsy (SUDEP) is the substantial cause of death in patients with epilepsy (PWE). Electroconductive disorders leading to life-threatening arrhythmia are mostly hypothesized to play a crucial role; however, there is paucity of knowledge in variable among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls. Methods: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. ECGs were taken when admitted at the hospital (base line), immediately after a seizure incidence and within an hour after the end of the seizure from the cases compared with a random ECG of the controls considering parameters including PR-, RR-, and corrected QT interval (QTc), P wave duration and heart rate (HR) variability. Results: Shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P-value=0.017) in the base line taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P-value=0.005) and heart rate (P-value=0.005). Post-ictal ECGs did not differ between the groups (P-value>0.05). Conclusion: According to the findings of this study, shortened QTc interval at base line ECGs, shortened RR interval and increased HR during the seizure were the ECG elements affected in drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.
{"title":"The Assessments of Electrocardiographic Parameters in the Patients with Drug-Resistant Temporal Lobe Epilepsy; A Case-Control Study","authors":"J. Mehvari, Zeinab Jaafari, Mohamad Zare, N. Tabrizi, Alireza Khosravi Farsani","doi":"10.32598/bcn.2023.4724.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.4724.1","url":null,"abstract":"Introduction: Sudden unexpected death in epilepsy (SUDEP) is the substantial cause of death in patients with epilepsy (PWE). Electroconductive disorders leading to life-threatening arrhythmia are mostly hypothesized to play a crucial role; however, there is paucity of knowledge in variable among the patients with drug-resistant temporal lobe epilepsy (TLE) compared to the healthy controls. Methods: The current case-control study has been conducted on 50 drug-resistant TLE patients as the cases and 50 age- and gender-matched healthy subjects selected from their first-degree family members. ECGs were taken when admitted at the hospital (base line), immediately after a seizure incidence and within an hour after the end of the seizure from the cases compared with a random ECG of the controls considering parameters including PR-, RR-, and corrected QT interval (QTc), P wave duration and heart rate (HR) variability. Results: Shorter corrected QTc interval was notified among the drug-resistant TLE patients compared to the controls (P-value=0.017) in the base line taken ECGs, while the assessments immediately after the seizure revealed significant differences in terms of RR-interval (P-value=0.005) and heart rate (P-value=0.005). Post-ictal ECGs did not differ between the groups (P-value>0.05). Conclusion: According to the findings of this study, shortened QTc interval at base line ECGs, shortened RR interval and increased HR during the seizure were the ECG elements affected in drug-resistant TLE patients; however, to generalize the outcomes, further studies are required.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75660581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.32598/bcn.2023.2368.1
H. Aliyari, Mohsen Hosseinian, M. Menhaj, H. Sahraei, Mohsen Shabani, M. Kazemi
High-voltage (HV) power transmission lines running near cities and villages can cause severe damage (Mental and physical). Due to the magnetic and electric fields they produce. This study aimed to investigate the effects of high-voltage (HV) electric fields on the spiking neural network model of the brain and biological and behavioral models of visual working memory. To achieve this goal, macaques were studied for their cognitive functions, expression of the NMDA receptor gene, MRI-assisted analysis of brain anatomy, and variations in blood sodium and potassium concentrations. The experimental group of macaques was exposed to a 3kV/m high-voltage field for four hours a day for one month. Computational models were then evaluated using experimental parameters. According to the results, it was observed that being exposed to high-voltage electric fields led to a reduction in the expression of the NMDA receptor gene, as well as a decrease in the levels of Sodium and potassium ions in the blood plasma. Additionally, analysis assisted by MRI showed a decrease in the volume of the hippocampus and amygdala after exposure to the electric field. In conclusion, the results of cognitive, genetic, blood, and MRI tests, along with the spiking neural network model, elucidate the mechanism of the visual working memory deterioration in macaques due to high-voltage electric field exposure.
{"title":"Uncovering the Neurobiological Consequences of High-Voltage Electrical Field Exposure on the Visual Working Memory of Macaques and Also Using Spiking Neural Network Model","authors":"H. Aliyari, Mohsen Hosseinian, M. Menhaj, H. Sahraei, Mohsen Shabani, M. Kazemi","doi":"10.32598/bcn.2023.2368.1","DOIUrl":"https://doi.org/10.32598/bcn.2023.2368.1","url":null,"abstract":"High-voltage (HV) power transmission lines running near cities and villages can cause severe damage (Mental and physical). Due to the magnetic and electric fields they produce. This study aimed to investigate the effects of high-voltage (HV) electric fields on the spiking neural network model of the brain and biological and behavioral models of visual working memory. To achieve this goal, macaques were studied for their cognitive functions, expression of the NMDA receptor gene, MRI-assisted analysis of brain anatomy, and variations in blood sodium and potassium concentrations. The experimental group of macaques was exposed to a 3kV/m high-voltage field for four hours a day for one month. Computational models were then evaluated using experimental parameters. According to the results, it was observed that being exposed to high-voltage electric fields led to a reduction in the expression of the NMDA receptor gene, as well as a decrease in the levels of Sodium and potassium ions in the blood plasma. Additionally, analysis assisted by MRI showed a decrease in the volume of the hippocampus and amygdala after exposure to the electric field. In conclusion, the results of cognitive, genetic, blood, and MRI tests, along with the spiking neural network model, elucidate the mechanism of the visual working memory deterioration in macaques due to high-voltage electric field exposure.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79355819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-26DOI: 10.32598/bcn.2023.1206.2
Hoda Taghilou, Mazaher Rezaei, M. Nazari, Alireza Valizadeh
Aims: Hypnosis is a multifaceted phenomenon and refers to suggestions that are used to create desirable changes in behavior, experience and physiology. Most EEG research in hypnosis have allocated people into two groups of high and low hypnotizables. Hence, the empirical data are somewhat controversial, and there is no general agreement about the neurophysiology of hypnosis. On the other hand, dissociation theory of hypnosis posits that people candidates for hypnosis are typically prone to dissociation and individuals divide into two groups with high dissociative (HD) and low dissociative (LD). If this assumption is true, we can expect such a state should be visible as a distinct pattern of changes in absolute power and functional connectivity between brain districts after a hypnotic induction in high but not low dissociative suggestible. Methods: The final sample consisted of 20 participants who scored six or higher on the SHSS: C. then we completed DES on them. To assess the electrical activity of the brain during hypnosis, nineteen channel EEG was recorded from 10 HD and 10 LD participants with their eyes closed before (baseline) and after the induction of hypnosis. We use EEG to measure absolute power and functional connectivity using coherence (COH). We expected that the two groups would have dissimilar pattern of EEG signals in spite of equivalent hypnotizability. Findings: We found that in in bands of delta, theta, alpha, beta, and gamma, both groups were different from the baseline to hypnosis. In addition, both groups showed different connectivity in hypnosis in four bands (delta, theta, alpha, and beta). Conclusion: These findings indicate that although the two LD low and HD groups had equal hypnotizability, the episodic prospection tasks did not involve the same neural networks in the two groups.
{"title":"EEG Oscillations during Prehypnosis and Hypnosis in Subjects with High and Low Dissociative Experiences","authors":"Hoda Taghilou, Mazaher Rezaei, M. Nazari, Alireza Valizadeh","doi":"10.32598/bcn.2023.1206.2","DOIUrl":"https://doi.org/10.32598/bcn.2023.1206.2","url":null,"abstract":"Aims: Hypnosis is a multifaceted phenomenon and refers to suggestions that are used to create desirable changes in behavior, experience and physiology. Most EEG research in hypnosis have allocated people into two groups of high and low hypnotizables. Hence, the empirical data are somewhat controversial, and there is no general agreement about the neurophysiology of hypnosis. On the other hand, dissociation theory of hypnosis posits that people candidates for hypnosis are typically prone to dissociation and individuals divide into two groups with high dissociative (HD) and low dissociative (LD). If this assumption is true, we can expect such a state should be visible as a distinct pattern of changes in absolute power and functional connectivity between brain districts after a hypnotic induction in high but not low dissociative suggestible. Methods: The final sample consisted of 20 participants who scored six or higher on the SHSS: C. then we completed DES on them. To assess the electrical activity of the brain during hypnosis, nineteen channel EEG was recorded from 10 HD and 10 LD participants with their eyes closed before (baseline) and after the induction of hypnosis. We use EEG to measure absolute power and functional connectivity using coherence (COH). We expected that the two groups would have dissimilar pattern of EEG signals in spite of equivalent hypnotizability. Findings: We found that in in bands of delta, theta, alpha, beta, and gamma, both groups were different from the baseline to hypnosis. In addition, both groups showed different connectivity in hypnosis in four bands (delta, theta, alpha, and beta). Conclusion: These findings indicate that although the two LD low and HD groups had equal hypnotizability, the episodic prospection tasks did not involve the same neural networks in the two groups.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89779750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarieh Ghasempour, N. Maghsoudi, H. Manaheji, Rasoul Ghasemi, Ali Jaafari Suha, J. Zaringhalam
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is identified by the gradual decline in memory and cognitive function. It is classified by the deposition of Aβ plaques, the build-up of intracellular neurofibrillary tangle and neuron loss. Neurotrophic factors play critical role in the treatment of Alzheimer's disease. However, the utilization of such neurotrophins has encountered certain difficulties and side effects. Novel technological advancements prioritize innovative dipeptides usage, which offer fewer side effects. The present study endeavors to analyze the compound hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine) (Lab name: H-MGL), a newly discovered neurotrophin mimetic dipeptide, with the aim of alleviating memory impairment in an intracerebroventricular single dose streptozotocin (STZ)-induced Alzheimer model in rats. We arranged 4 groups consist of sham, groups receiving STZ and STZ+H-MGL (1 and 2mg/kg). The H-MGL was administered consecutively for 14 days following STZ injection subsequently, the Morris Water Maze test was performed. The findings suggest that administration of STZ caused significantly increment in mean escape latency and mean traveled distance in acquisition days. H-MGL at a dosage of 1mg/kg failed to yield any notable improvement in rats when compared to STZ. By contrast, a dosage of 2mg/kg of H-MGL led to a significant decrease in the latency to first platform crossing and frequency of platform crossings. Consequently, the aforementioned findings have engendered the notion that H-MGL partially ameliorate cognitive impairment so it may hold promise for having low side effects to alleviate cognitive deficits in Alzheimer's disease, or potentially decreases the symptoms associated with its progression.
{"title":"A New Dipeptide H-MGL Partially Ameliorates Memory Impairment in an STZ-Induced Alzheimer Model in Male Rats","authors":"Sarieh Ghasempour, N. Maghsoudi, H. Manaheji, Rasoul Ghasemi, Ali Jaafari Suha, J. Zaringhalam","doi":"10.32598/bcn.2023.401.3","DOIUrl":"https://doi.org/10.32598/bcn.2023.401.3","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is identified by the gradual decline in memory and cognitive function. It is classified by the deposition of Aβ plaques, the build-up of intracellular neurofibrillary tangle and neuron loss. Neurotrophic factors play critical role in the treatment of Alzheimer's disease. However, the utilization of such neurotrophins has encountered certain difficulties and side effects. Novel technological advancements prioritize innovative dipeptides usage, which offer fewer side effects. The present study endeavors to analyze the compound hexamethylenediamide bis-(N-monosuccinyl-glutamyl-lysine) (Lab name: H-MGL), a newly discovered neurotrophin mimetic dipeptide, with the aim of alleviating memory impairment in an intracerebroventricular single dose streptozotocin (STZ)-induced Alzheimer model in rats. We arranged 4 groups consist of sham, groups receiving STZ and STZ+H-MGL (1 and 2mg/kg). The H-MGL was administered consecutively for 14 days following STZ injection subsequently, the Morris Water Maze test was performed. The findings suggest that administration of STZ caused significantly increment in mean escape latency and mean traveled distance in acquisition days. H-MGL at a dosage of 1mg/kg failed to yield any notable improvement in rats when compared to STZ. By contrast, a dosage of 2mg/kg of H-MGL led to a significant decrease in the latency to first platform crossing and frequency of platform crossings. Consequently, the aforementioned findings have engendered the notion that H-MGL partially ameliorate cognitive impairment so it may hold promise for having low side effects to alleviate cognitive deficits in Alzheimer's disease, or potentially decreases the symptoms associated with its progression.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87207091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Atefeh Fadaei, M. Najafi, H. Miladi-Gorji, Mohammad Ali Tajik Mansoury, Mohammad Afkar
Introduction: In this study, we investigated whether neurofeedback (NFB) training and swimming exercise would decrease the electroencephalographic (EEG) changes and visual image-induced craving in methamphetamine (METH)-dependent patients. Methods: This study was a randomized controlled trial design. 32 METH-dependent patients were allocated randomly to four groups; control, NFB, Swim, and NFB/Swim. The EEG and visual image-induced craving were recorded before and after the intervention in all four groups. Results: We found that the NFB, Swim, and NFB/Swim groups showed significantly lower absolute power for 4 frequency bands. Also, the swim and NFB/Swim groups had less and greater relative power in the alpha and delta bands, respectively. In addition, NFB/Swim group exhibited an increase in delta/alpha power ratio than the control and the NFB groups. Also, the NFB/Swim group showed a significant reduction in visual image-induced craving score than the control, swim, and NFB groups. Conclusion: This study provides novel evidence that the NFB training along with swimming exercise during METH-abstinence was effective in the normalization of METH-induced EEG changes, which may help patients to manage their cravings.
{"title":"Effect of Neurofeedback Training Along with Swimming Exercise on the Electroencephalographic Changes and Visual Image-Induced Craving in Methamphetamine-Dependent Patients","authors":"Atefeh Fadaei, M. Najafi, H. Miladi-Gorji, Mohammad Ali Tajik Mansoury, Mohammad Afkar","doi":"10.32598/bcn.2023.886.4","DOIUrl":"https://doi.org/10.32598/bcn.2023.886.4","url":null,"abstract":"Introduction: In this study, we investigated whether neurofeedback (NFB) training and swimming exercise would decrease the electroencephalographic (EEG) changes and visual image-induced craving in methamphetamine (METH)-dependent patients. Methods: This study was a randomized controlled trial design. 32 METH-dependent patients were allocated randomly to four groups; control, NFB, Swim, and NFB/Swim. The EEG and visual image-induced craving were recorded before and after the intervention in all four groups. Results: We found that the NFB, Swim, and NFB/Swim groups showed significantly lower absolute power for 4 frequency bands. Also, the swim and NFB/Swim groups had less and greater relative power in the alpha and delta bands, respectively. In addition, NFB/Swim group exhibited an increase in delta/alpha power ratio than the control and the NFB groups. Also, the NFB/Swim group showed a significant reduction in visual image-induced craving score than the control, swim, and NFB groups. Conclusion: This study provides novel evidence that the NFB training along with swimming exercise during METH-abstinence was effective in the normalization of METH-induced EEG changes, which may help patients to manage their cravings.","PeriodicalId":8728,"journal":{"name":"Basic and Clinical Neuroscience Journal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85283687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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