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Snapping knee in infant 婴儿膝盖折断
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.03.001
Carmen Hernández Marques , María Jesús Escribano Romero , Carlos Miranda Gorozarri
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引用次数: 0
Consensus document of the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Intensive Care (SECIP) for the diagnosis and treatment of central venous catheter-related infections in paediatric care 西班牙儿科传染病学会 (SEIP) 和西班牙儿科重症监护学会 (SECIP) 关于儿科护理中中央静脉导管相关感染诊断和治疗的共识文件。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.05.012
Jesús Saavedra-Lozano , María Slocker-Barrio , Elena Fresán-Ruiz , Carlos Grasa , Laura Martín Pedraz , Ana Menasalvas Ruiz , Mar Santos Sebastián

Intravascular devices are essential for the diagnostic and therapeutic approach to multiple diseases in paediatrics, and central venous catheters (CVCs) are especially important. One of the most frequent complications is the infection of these devices, which is associated with a high morbidity and mortality. These infections are highly complex, requiring the use of substantial resources, both for their diagnosis and treatment, and affect vulnerable paediatric patients admitted to high-complexity units more frequently. There is less evidence on their management in paediatric patients compared to adults, and no consensus documents on the subject have been published in Spain. The objective of this document, developed jointly by the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Intensive Care (SECIP), is to provide consensus recommendations based on the greatest degree of evidence available to optimize the diagnosis and treatment of catheter-related bloodstream infections (CRBSIs). This document focuses on non-neonatal paediatric patients with CRBSIs and does not address the prevention of these infections.

血管内装置对于儿科多种疾病的诊断和治疗至关重要,而中心静脉导管(CVC)尤为重要。最常见的并发症之一就是这些设备的感染,其发病率和死亡率都很高。这些感染非常复杂,在诊断和治疗方面都需要动用大量资源,而且更频繁地影响到入住复杂性高的病房的脆弱儿科患者。与成人相比,儿科患者的感染管理证据较少,西班牙也未出版过相关的共识文件。本文件由西班牙儿科传染病学会(SEIP)和西班牙儿科重症监护学会(SECIP)联合制定,旨在根据现有的最大量证据提供共识建议,以优化导管相关血流感染(CRBSI)的诊断和治疗。本文件主要针对患有 CRBSI 的非新生儿儿科患者,并不涉及这些感染的预防。
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引用次数: 0
It’s not all ingrowing nail: Childhood retronychia 不全是嵌甲:儿童甲沟炎
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.03.003
Cristina Nogueroles Blanco , Sara Fuentes Carretero , Carme Grande Moreillo , Jaume Margarit Mallol
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引用次数: 0
Phlebectasia of the right jugular vein 右颈静脉静脉扩张。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.05.010
María José Sánchez Malo , Lorena Miñones Suárez , Rasha Isabel Perez Ajami , María Santos González
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引用次数: 0
Esophageal desquamation in pediatrics. Esophagitis dissecans superficialis 儿科食管脱屑。浅表食管闭锁性食管炎。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.05.002
Bruna Surinyac-Ayats , Sara Serra Font , Jocelyn Betancourt , Justyna Szafranska , Susana Boronat
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引用次数: 0
A growing disconnection from nature. Urgent call to action for a nature prescription global health alliance 与自然日益脱节。紧急呼吁采取行动,建立自然处方全球健康联盟。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.03.004
Juan Antonio Ortega-García , Concepción Martínez-Gómez , Albert Bach , Laura Benitez-Rodríguez , Rebeca Ramis , en representación de la Alianza GRSIA
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引用次数: 0
Percutaneous closure of big interventricular septal defect in an infant 经皮关闭婴儿室间隔大缺损。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.05.003
Luis Fernandez Gonzalez , Roberto Blanco Mata , Javier Ayala Curiel , Jose Luis Zunzunegui Martinez
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引用次数: 0
Composition of the microbiota in patients with growth hormone deficiency before and after treatment with growth hormone 生长激素治疗前后生长激素缺乏症患者微生物群的组成。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.05.004
Patricia García Navas , María Yolanda Ruíz del Prado , Pablo Villoslada Blanco , Emma Recio Fernández , María Ruíz del Campo , Patricia Pérez Matute

Introduction

Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have modulatory effects on bowel function and its microbiota. Our aim was to investigate whether low levels of GH and IGF-1 in patients with GH deficiency are associated with changes in gut physiology/integrity as well as in the composition of the gut microbiota.

Materials and methods

We conducted a case-control study in 21 patients with GH deficiency, at baseline and after 6 months of GH treatment, and in 20 healthy controls. We analysed changes in anthropometric and laboratory characteristics and bacterial translocation and studied the composition of the microbiome by means of massive 16S rRNA gene sequencing.

Results

Growth hormone deficiency was accompanied by a significant increase in serum levels of sCD14, a marker of bacterial translocation (P < .01). This increase was reversed by GH treatment. We did not find any differences in the composition or α- or β-diversity of the gut microbiota after treatment or between cases and controls.

Conclusions

Our work is the first to demonstrate that the presence of GH deficiency is not associated with differences in gut microbiota composition in comparison with healthy controls, and changes in microbiota composition are also not found after 6 months of treatment. However, GH deficiency and low IGF-1 levels were associated with an increase in bacterial translocation, which had reversed after treatment.

导言:生长激素(GH)和胰岛素样生长因子-1(IGF-1)对肠道功能及其微生物群具有调节作用。我们的目的是研究 GH 缺乏症患者体内的低水平 GH 和 IGF-1 是否与肠道生理/完整性以及肠道微生物群组成的变化有关:我们对 21 名 GH 缺乏症患者(基线和接受 6 个月 GH 治疗后)和 20 名健康对照者进行了病例对照研究。我们分析了人体测量和实验室特征以及细菌易位的变化,并通过大量 16S rRNA 基因测序研究了微生物群的组成:结果:在生长激素缺乏的同时,血清中的 sCD14 水平显著增加,而 sCD14 是细菌易位的标志物:我们的研究首次证明,与健康对照组相比,生长激素缺乏症与肠道微生物群组成的差异无关,而且在治疗 6 个月后也未发现微生物群组成的变化。然而,GH 缺乏症和低 IGF-1 水平与细菌易位的增加有关,这种情况在治疗后发生了逆转。
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引用次数: 0
Predictors of adherence to follow-up and treatment success in childhood obesity 儿童肥胖症患者坚持随访和治疗成功的预测因素。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.05.007
Ana Zamora Auñón , Blanca Guijo Alonso , Eva María De Andrés Esteban , Jesús Argente , Gabriel Á. Martos-Moreno

Introduction

Management of childhood obesity, based upon behavioural, physical activity and dietary guidance, usually achieves limited success and is hindered by a high attrition rate. The identification of potential predictors of either weight loss or early weight management attrition could help develop personalised management plans in order to improve patient outcomes.

Patients and methods

We conducted a retrospective study in a cohort of 1300 patients with obesity managed in speciality clinics for up to 5 years with outpatient conservative treatment. We studied the family background and personal characteristics (demographic, behavioural, psychosocial, anthropometric and metabolic) of patients who dropped out before completing the first year of the programme and patients who achieved significant weight loss, with a separate analysis of patients who achieved substantial reductions in weight compared to the rest of the cohort.

Results

The mean age of the patients in the cohort was 10.46 years (SD, 3.48) the mean BMI z-score 4.01 (SD, 1.49); 52.8% of the patients were male, 53.3% were prepubertal, 75.8% were Caucasian and 19% Latin. We found a higher proportion of Latinla ethnicity and compulsive eating in the group of patients with early attrition from the weight management follow-up. In the group of patients with substantial weight loss, a greater proportion were male, there was a higher frequency of dietary intake control at home and obesity was more severe, and the latter factor was consistently observed in patients who achieved substantial weight loss at any point of the follow-up.

Conclusions

Some family and personal characteristics in childhood obesity are associated with an increased risk of early withdrawal from follow-up or a greater probability of successful outcomes; however, the predictive value of these variables is limited.

导言:基于行为、体育锻炼和饮食指导的儿童肥胖症管理通常收效甚微,并受到高减员率的阻碍。确定体重减轻或早期体重管理减员的潜在预测因素有助于制定个性化的管理计划,从而改善患者的治疗效果:我们对 1300 名肥胖症患者进行了一项回顾性研究,这些患者在专科门诊接受了长达 5 年的门诊保守治疗。我们研究了未完成第一年治疗计划而辍学的患者和体重明显减轻的患者的家庭背景和个人特征(人口学、行为学、社会心理学、人体测量学和代谢),并对与其他患者相比体重明显减轻的患者进行了单独分析:队列中患者的平均年龄为 10.46 岁(SD,3.48),平均体重指数 z 值为 4.01(SD,1.49);52.8% 的患者为男性,53.3% 的患者青春期前,75.8% 的患者为白种人,19% 的患者为拉丁人。我们发现,在体重管理随访早期流失的患者群体中,拉丁裔和强迫性进食的比例较高。在体重大幅下降的患者群体中,男性比例更高,在家中控制饮食摄入的频率更高,肥胖程度更严重:结论:儿童肥胖症患者的一些家庭和个人特征与早期退出随访的风险增加或更有可能取得成功结果有关;但是,这些变量的预测价值有限。
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引用次数: 0
Annual report of the editors of Anales de Pediatría Anales de Pediatría 编辑的年度报告。
Pub Date : 2024-06-01 DOI: 10.1016/j.anpede.2024.06.001
Montserrat Antón-Gamero , Alejandro Avila-Alvarez , Josep Vicent Balaguer-Martínez , Mercedes Bueno Campaña , Rafael Galera-Martínez
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Anales de pediatria
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