Pub Date : 2024-06-01DOI: 10.1016/j.anpede.2024.05.012
Jesús Saavedra-Lozano , María Slocker-Barrio , Elena Fresán-Ruiz , Carlos Grasa , Laura Martín Pedraz , Ana Menasalvas Ruiz , Mar Santos Sebastián
Intravascular devices are essential for the diagnostic and therapeutic approach to multiple diseases in paediatrics, and central venous catheters (CVCs) are especially important. One of the most frequent complications is the infection of these devices, which is associated with a high morbidity and mortality. These infections are highly complex, requiring the use of substantial resources, both for their diagnosis and treatment, and affect vulnerable paediatric patients admitted to high-complexity units more frequently. There is less evidence on their management in paediatric patients compared to adults, and no consensus documents on the subject have been published in Spain. The objective of this document, developed jointly by the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Intensive Care (SECIP), is to provide consensus recommendations based on the greatest degree of evidence available to optimize the diagnosis and treatment of catheter-related bloodstream infections (CRBSIs). This document focuses on non-neonatal paediatric patients with CRBSIs and does not address the prevention of these infections.
{"title":"Consensus document of the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Intensive Care (SECIP) for the diagnosis and treatment of central venous catheter-related infections in paediatric care","authors":"Jesús Saavedra-Lozano , María Slocker-Barrio , Elena Fresán-Ruiz , Carlos Grasa , Laura Martín Pedraz , Ana Menasalvas Ruiz , Mar Santos Sebastián","doi":"10.1016/j.anpede.2024.05.012","DOIUrl":"10.1016/j.anpede.2024.05.012","url":null,"abstract":"<div><p>Intravascular devices are essential for the diagnostic and therapeutic approach to multiple diseases in paediatrics, and central venous catheters (CVCs) are especially important. One of the most frequent complications is the infection of these devices, which is associated with a high morbidity and mortality. These infections are highly complex, requiring the use of substantial resources, both for their diagnosis and treatment, and affect vulnerable paediatric patients admitted to high-complexity units more frequently. There is less evidence on their management in paediatric patients compared to adults, and no consensus documents on the subject have been published in Spain. The objective of this document, developed jointly by the Spanish Society of Paediatric Infectious Diseases (SEIP) and the Spanish Society of Paediatric Intensive Care (SECIP), is to provide consensus recommendations based on the greatest degree of evidence available to optimize the diagnosis and treatment of catheter-related bloodstream infections (CRBSIs). This document focuses on non-neonatal paediatric patients with CRBSIs and does not address the prevention of these infections.</p></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages 448-464"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2341287924001613/pdfft?md5=8b68dba90923648aa7a10e4f5bc3afa7&pid=1-s2.0-S2341287924001613-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141461277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.anpede.2024.05.010
María José Sánchez Malo , Lorena Miñones Suárez , Rasha Isabel Perez Ajami , María Santos González
{"title":"Phlebectasia of the right jugular vein","authors":"María José Sánchez Malo , Lorena Miñones Suárez , Rasha Isabel Perez Ajami , María Santos González","doi":"10.1016/j.anpede.2024.05.010","DOIUrl":"10.1016/j.anpede.2024.05.010","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages 482-483"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2341287924001571/pdfft?md5=c846c59cd7f2f735365fd827624944e4&pid=1-s2.0-S2341287924001571-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.anpede.2024.03.004
Juan Antonio Ortega-García , Concepción Martínez-Gómez , Albert Bach , Laura Benitez-Rodríguez , Rebeca Ramis , en representación de la Alianza GRSIA
{"title":"A growing disconnection from nature. Urgent call to action for a nature prescription global health alliance","authors":"Juan Antonio Ortega-García , Concepción Martínez-Gómez , Albert Bach , Laura Benitez-Rodríguez , Rebeca Ramis , en representación de la Alianza GRSIA","doi":"10.1016/j.anpede.2024.03.004","DOIUrl":"10.1016/j.anpede.2024.03.004","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages e10-e12"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2341287924000541/pdfft?md5=edc197c4b2a2b93cfd0629de4183758c&pid=1-s2.0-S2341287924000541-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140137604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.anpede.2024.05.003
Luis Fernandez Gonzalez , Roberto Blanco Mata , Javier Ayala Curiel , Jose Luis Zunzunegui Martinez
{"title":"Percutaneous closure of big interventricular septal defect in an infant","authors":"Luis Fernandez Gonzalez , Roberto Blanco Mata , Javier Ayala Curiel , Jose Luis Zunzunegui Martinez","doi":"10.1016/j.anpede.2024.05.003","DOIUrl":"10.1016/j.anpede.2024.05.003","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages 475-477"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S234128792400142X/pdfft?md5=c1381acfc3785bb8a3aa736492eeabc8&pid=1-s2.0-S234128792400142X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.anpede.2024.05.004
Patricia García Navas , María Yolanda Ruíz del Prado , Pablo Villoslada Blanco , Emma Recio Fernández , María Ruíz del Campo , Patricia Pérez Matute
Introduction
Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have modulatory effects on bowel function and its microbiota. Our aim was to investigate whether low levels of GH and IGF-1 in patients with GH deficiency are associated with changes in gut physiology/integrity as well as in the composition of the gut microbiota.
Materials and methods
We conducted a case-control study in 21 patients with GH deficiency, at baseline and after 6 months of GH treatment, and in 20 healthy controls. We analysed changes in anthropometric and laboratory characteristics and bacterial translocation and studied the composition of the microbiome by means of massive 16S rRNA gene sequencing.
Results
Growth hormone deficiency was accompanied by a significant increase in serum levels of sCD14, a marker of bacterial translocation (P < .01). This increase was reversed by GH treatment. We did not find any differences in the composition or α- or β-diversity of the gut microbiota after treatment or between cases and controls.
Conclusions
Our work is the first to demonstrate that the presence of GH deficiency is not associated with differences in gut microbiota composition in comparison with healthy controls, and changes in microbiota composition are also not found after 6 months of treatment. However, GH deficiency and low IGF-1 levels were associated with an increase in bacterial translocation, which had reversed after treatment.
{"title":"Composition of the microbiota in patients with growth hormone deficiency before and after treatment with growth hormone","authors":"Patricia García Navas , María Yolanda Ruíz del Prado , Pablo Villoslada Blanco , Emma Recio Fernández , María Ruíz del Campo , Patricia Pérez Matute","doi":"10.1016/j.anpede.2024.05.004","DOIUrl":"10.1016/j.anpede.2024.05.004","url":null,"abstract":"<div><h3>Introduction</h3><p>Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) have modulatory effects on bowel function and its microbiota. Our aim was to investigate whether low levels of GH and IGF-1 in patients with GH deficiency are associated with changes in gut physiology/integrity as well as in the composition of the gut microbiota.</p></div><div><h3>Materials and methods</h3><p>We conducted a case-control study in 21 patients with GH deficiency, at baseline and after 6 months of GH treatment, and in 20 healthy controls. We analysed changes in anthropometric and laboratory characteristics and bacterial translocation and studied the composition of the microbiome by means of massive 16S rRNA gene sequencing.</p></div><div><h3>Results</h3><p>Growth hormone deficiency was accompanied by a significant increase in serum levels of sCD14, a marker of bacterial translocation (<em>P</em> < .01). This increase was reversed by GH treatment. We did not find any differences in the composition or α- or β-diversity of the gut microbiota after treatment or between cases and controls.</p></div><div><h3>Conclusions</h3><p>Our work is the first to demonstrate that the presence of GH deficiency is not associated with differences in gut microbiota composition in comparison with healthy controls, and changes in microbiota composition are also not found after 6 months of treatment. However, GH deficiency and low IGF-1 levels were associated with an increase in bacterial translocation, which had reversed after treatment.</p></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages 404-411"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2341287924001431/pdfft?md5=588aee843a4264312dc29d3344efa340&pid=1-s2.0-S2341287924001431-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141162561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.anpede.2024.05.007
Ana Zamora Auñón , Blanca Guijo Alonso , Eva María De Andrés Esteban , Jesús Argente , Gabriel Á. Martos-Moreno
Introduction
Management of childhood obesity, based upon behavioural, physical activity and dietary guidance, usually achieves limited success and is hindered by a high attrition rate. The identification of potential predictors of either weight loss or early weight management attrition could help develop personalised management plans in order to improve patient outcomes.
Patients and methods
We conducted a retrospective study in a cohort of 1300 patients with obesity managed in speciality clinics for up to 5 years with outpatient conservative treatment. We studied the family background and personal characteristics (demographic, behavioural, psychosocial, anthropometric and metabolic) of patients who dropped out before completing the first year of the programme and patients who achieved significant weight loss, with a separate analysis of patients who achieved substantial reductions in weight compared to the rest of the cohort.
Results
The mean age of the patients in the cohort was 10.46 years (SD, 3.48) the mean BMI z-score 4.01 (SD, 1.49); 52.8% of the patients were male, 53.3% were prepubertal, 75.8% were Caucasian and 19% Latin. We found a higher proportion of Latinla ethnicity and compulsive eating in the group of patients with early attrition from the weight management follow-up. In the group of patients with substantial weight loss, a greater proportion were male, there was a higher frequency of dietary intake control at home and obesity was more severe, and the latter factor was consistently observed in patients who achieved substantial weight loss at any point of the follow-up.
Conclusions
Some family and personal characteristics in childhood obesity are associated with an increased risk of early withdrawal from follow-up or a greater probability of successful outcomes; however, the predictive value of these variables is limited.
{"title":"Predictors of adherence to follow-up and treatment success in childhood obesity","authors":"Ana Zamora Auñón , Blanca Guijo Alonso , Eva María De Andrés Esteban , Jesús Argente , Gabriel Á. Martos-Moreno","doi":"10.1016/j.anpede.2024.05.007","DOIUrl":"10.1016/j.anpede.2024.05.007","url":null,"abstract":"<div><h3>Introduction</h3><p>Management of childhood obesity, based upon behavioural, physical activity and dietary guidance, usually achieves limited success and is hindered by a high attrition rate. The identification of potential predictors of either weight loss or early weight management attrition could help develop personalised management plans in order to improve patient outcomes.</p></div><div><h3>Patients and methods</h3><p>We conducted a retrospective study in a cohort of 1300 patients with obesity managed in speciality clinics for up to 5 years with outpatient conservative treatment. We studied the family background and personal characteristics (demographic, behavioural, psychosocial, anthropometric and metabolic) of patients who dropped out before completing the first year of the programme and patients who achieved significant weight loss, with a separate analysis of patients who achieved substantial reductions in weight compared to the rest of the cohort.</p></div><div><h3>Results</h3><p>The mean age of the patients in the cohort was 10.46 years (SD, 3.48) the mean BMI <em>z</em>-score 4.01 (SD, 1.49); 52.8% of the patients were male, 53.3% were prepubertal, 75.8% were Caucasian and 19% Latin. We found a higher proportion of Latinla ethnicity and compulsive eating in the group of patients with early attrition from the weight management follow-up. In the group of patients with substantial weight loss, a greater proportion were male, there was a higher frequency of dietary intake control at home and obesity was more severe, and the latter factor was consistently observed in patients who achieved substantial weight loss at any point of the follow-up.</p></div><div><h3>Conclusions</h3><p>Some family and personal characteristics in childhood obesity are associated with an increased risk of early withdrawal from follow-up or a greater probability of successful outcomes; however, the predictive value of these variables is limited.</p></div>","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages 428-437"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2341287924001467/pdfft?md5=0ea8dd3bc441fc58d3fb6f90c1dbac8c&pid=1-s2.0-S2341287924001467-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Annual report of the editors of Anales de Pediatría","authors":"Montserrat Antón-Gamero , Alejandro Avila-Alvarez , Josep Vicent Balaguer-Martínez , Mercedes Bueno Campaña , Rafael Galera-Martínez","doi":"10.1016/j.anpede.2024.06.001","DOIUrl":"10.1016/j.anpede.2024.06.001","url":null,"abstract":"","PeriodicalId":93868,"journal":{"name":"Anales de pediatria","volume":"100 6","pages":"Pages 393-400"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2341287924001625/pdfft?md5=cedc305918e428aacfd9343e7885e92d&pid=1-s2.0-S2341287924001625-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141294010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}