三个系统的故事:建立肥胖症的神经免疫内分泌模型。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2021-10-06 DOI:10.1146/annurev-cellbio-120319-114106
Conan J O O'Brien, Emma R Haberman, Ana I Domingos
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引用次数: 0

摘要

肥胖症的发病率呈上升趋势。肥胖症曾被认为是一种简单的能量失衡疾病,但现在却被认为是一种由神经和免疫病理导致的复杂疾病。在这篇综述中,我们总结了目前有关肥胖症神经免疫内分泌机制的知识。除了瘦素在调节食欲方面的既定作用外,我们还研究了瘦素作用的多效应,并讨论了介导瘦素作用的神经回路,以及肥胖症如何在中枢(瘦素抵抗)和脂肪组织(交感神经病变)两方面改变瘦素的作用。最后,我们剖析了脂肪组织巨噬细胞在肥胖症中的众多因果作用,并重点介绍了近期证明其在机体能量平衡中直接作用的重要研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity.

The prevalence of obesity is on the rise. What was once considered a simple disease of energy imbalance is now recognized as a complex condition perpetuated by neuro- and immunopathologies. In this review, we summarize the current knowledge of the neuroimmunoendocrine mechanisms underlying obesity. We examine the pleiotropic effects of leptin action in addition to its established role in the modulation of appetite, and we discuss the neural circuitry mediating leptin action and how this is altered with obesity, both centrally (leptin resistance) and in adipose tissues (sympathetic neuropathy). Finally, we dissect the numerous causal and consequential roles of adipose tissue macrophages in obesity and highlight recent key studies demonstrating their direct role in organismal energy homeostasis.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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