【肢端肥大症在听力损失的鉴别诊断】。

Q4 Medicine Problemy endokrinologii Pub Date : 2023-05-11 DOI:10.14341/probl13249
L K Dzeranova, L I Lepeshkina, A S Shutova, M A Perepelova, E A Pigarova, V N Azizyan, P V Akopyan, Е G Przhialkovskaya, G A Melnichenko, N G Mokrysheva
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摘要

肢端肥大症是一种由生长激素(GH)分泌过多引起的多因素神经内分泌疾病。在95%以上的病例中,肢端肥大症的病因是gh分泌垂体腺瘤。在这种神经内分泌疾病的患者中,一个缓慢发展的复杂症状可以表现为伴随的病理状况,包括听觉功能障碍。肢端肥大症在门诊阶段的诊断困难决定了不同医学专业医生认识的重要性。我们在此报告一例垂体大腺瘤、肢端肥大症及听力丧失患者经外科及内科联合治疗后听觉功能改善的临床病例。回顾性分析:患者为肢端肥大症活动期,伴有垂体大腺瘤,尺寸为57x35x32mm,鞍前、鞍上、鞍下扩散,(Knosp III(D)、Knosp IV(S),注意到听觉功能受损。她咨询了耳鼻喉科医生,诊断为3度右侧的感觉神经性听力损失,1度左侧的感觉神经性听力损失。患者接受垂体腺瘤手术治疗,术后早期听觉功能有明显改善。6个月后复查听力学,发现听力损伤明显消退。我们所描述的病例表明可逆性肢端肥大症罕见的并发症-听力损失和跨学科方法的重要性,在患者的管理与这种病理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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[Acromegaly in the differential diagnosis of hearing loss].

Acromegaly is a multifactorial neuroendocrine disease caused by hyperproduction of growth hormone (GH). In more than 95% of cases the reason of acromegaly the GH-secreting pituitary adenoma. In patients with this neuroendocrine disease, a slowly developing complex of symptom can manifest with concomitant pathological conditions, including auditory function disordersDiagnostic difficulties of acromegaly at the ambulatory stage determine the importance of doctor`s awareness in different medical specialties.Here we demonstrate a clinical case of the improvement of the auditory function due to combined surgical and medical treatment of a patient with the pituitary macroadenoma, acromegaly and hearing loss.Anamnesis features: a patient with an active stage of acromegaly and a pituitary macroadenoma measuring 57x35x32 mm with ante-, supra-, infra-, parasellar spread, (Knosp III(D), Knosp IV(S) noted a violation of auditory function. She was consulted by an otolaryngologist, sensorineural hearing loss on the right of the 3rd degree was diagnosed, on the left of the 1st degree. The patient underwent surgical treatment of pituitary adenoma, noted a significant improvement in auditory function in the early postoperative period. Six months later, repeated audiometry was performed, marked regression of hearing damage was noted.The case described by us indicates the reversibility of a rare complication of acromegaly - hearing loss and the importance of an interdisciplinary approach in the management of patients with this pathology.

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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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