心脏手术后早期细胞因子风暴反应特征的研究。

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2023-08-01 DOI:10.1089/jir.2023.0044
Danyang Zhao, Rongli Yang, Sibo Liu, Dong Ge, Xiaolei Su
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引用次数: 1

摘要

心脏手术可引起急性细胞因子风暴,可能有助于术后多器官功能障碍综合征的发展。我们前瞻性观察心脏手术患者,并将其分为重度组和轻度组。招募健康个体作为对照组进行比较。分别在心肺分流术(CPB)开始时和CPB开始后3、6、12、24、48 h记录血浆样本和临床数据。使用Luminex®技术检测细胞因子水平。39名成年人参加了这项研究(重度组14人,轻度组15人,对照组10人)。重度组细胞因子浓度明显增高。通过主成分分析,建立了细胞因子风暴强度曲线,该曲线代表了10种细胞因子的总体趋势。白细胞介素(IL)-6、IL-10和IL-16的峰值浓度分别为425.1、198.5和623.0 pg/mL,分别是正常水平的1200、1800和240倍以上。在严重组中,最大细胞因子风暴强度早于最大血管活性-肌力评分(VIS)和序贯器官衰竭评估(SOFA)评分。心脏手术后的细胞因子风暴反应发生较早,且与疾病严重程度相关。在接受心脏手术的重症患者中,应在细胞因子风暴生物标志物如IL-6、IL-10和IL-16的指导下,尽早开始干预细胞因子风暴。临床试验注册:ChiCTR1900021351。
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Study on the Characteristics of Early Cytokine Storm Response to Cardiac Surgery.

Cardiac surgery can provoke an acute cytokine storm that may contribute to the development of postoperative multiple organ dysfunction syndrome. We prospectively observed patients undergoing cardiac surgery and divided them into two groups: the severe group and the mild group. Healthy individuals were enrolled acting as the control group for comparison. Plasma samples and clinical data were recorded at the initiation of cardiac-pulmonary bypass (CPB) and 3, 6, 12, 24, and 48 h after initiation of CPB. Cytokine levels were detected using the Luminex® technique. Thirty-nine adults were enrolled in this study (14 in the severe group, 15 in the mild group, and 10 in the control group). Cytokine concentrations were significantly higher in the severe group. Principal component analysis was used to establish a cytokine storm intensity curve, which represented the overall trend of 10 cytokines. The peak concentrations of interleukin (IL)-6, IL-10, and IL-16 were 425.1, 198.5, and 623.0 pg/mL, which were more than 1,200, 1,800, and 240 times the normal level, respectively. The maximum cytokine storm intensity predated the maximum Vasoactive-Inotropic Score (VIS) and Sequential Organ Failure Assessment (SOFA) score in the severe group. Cytokine storm response to cardiac surgery occurred early and was associated with disease severity. Interventions to cytokine storm should be initiated early as guided by cytokine storm biomarkers such as IL-6, IL-10, and IL-16 in severe patients undergoing cardiac surgery. Clinical Trial Registration: ChiCTR1900021351.

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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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