比沙芬可引起斑马鱼（Danio rerio）的肝毒性和胰腺毒性。

IF 2.4 4区环境科学与生态学 Q2 ECOLOGY Ecotoxicology Pub Date : 2023-09-01 Epub Date: 2023-08-19 DOI:10.1007/s10646-023-02687-y

Yini Wang, Huihan Peng, Hailing Yu

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引用次数: 0

摘要

Bixafen（BIX）是一种在农业疾病控制中广泛使用的琥珀酸脱氢酶抑制剂，由于其对水生生物的有害影响而引起了人们的极大关注。在这项研究中，我们将斑马鱼胚胎暴露于0.1、0.2和0.3 μM BIX，以探讨BIX对肝脏和胰腺的影响。结果表明，BIX导致斑马鱼胚胎畸形和功能障碍，包括脊柱弯曲、心包水肿、心率下降和孵化延迟。此外，BIX显著影响斑马鱼肝脏和胰腺的发育，并下调斑马鱼fabp10a基因的表达。总的来说，这项研究为BIX对斑马鱼肝脏和胰腺的潜在毒性提供了有力的证据。研究结果可能为评价BIX对水生生物的影响提供新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bixafen causes hepatotoxicity and pancreas toxicity in zebrafish (Danio rerio).

Bixafen (BIX), a widely used succinate dehydrogenase inhibitor (SDHI) in agricultural disease control, has garnered significant attention due to its known hazardous effects on aquatic organisms. In this study, we exposed zebrafish embryos to 0.1, 0.2, and 0.3 μM BIX, to explore the impact of BIX on liver and pancreas. The results showed that BIX caused deformities and dysfunction in zebrafish embryos, including spinal curvature, pericardial edema, heart rate decrease, and hatching delay. Moreover, BIX significantly affected the development of the liver and pancreas in zebrafish and downregulated zebrafish fabp10a gene expression. Overall, this study presents strong evidence for BIX's potential toxicity to zebrafish liver and pancreas. The results may provide new insights into the evaluation of BIX'S impact on aquatic organisms.

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来源期刊

Ecotoxicology 环境科学-毒理学

CiteScore

5.30

自引率

3.70%

发文量

107

审稿时长

4.7 months

期刊介绍： Ecotoxicology is an international journal devoted to the publication of fundamental research on the effects of toxic chemicals on populations, communities and terrestrial, freshwater and marine ecosystems. It aims to elucidate mechanisms and processes whereby chemicals exert their effects on ecosystems and the impact caused at the population or community level. The journal is not biased with respect to taxon or biome, and papers that indicate possible new approaches to regulation and control of toxic chemicals and those aiding in formulating ways of conserving threatened species are particularly welcome. Studies on individuals should demonstrate linkage to population effects in clear and quantitative ways. Laboratory studies must show a clear linkage to specific field situations. The journal includes not only original research papers but technical notes and review articles, both invited and submitted. A strong, broadly based editorial board ensures as wide an international coverage as possible.