通过贻贝启发粘合剂作为骨替代物增强磷酸钙水门汀的力学性能:它们之间相互作用的亮点。

IF 1 4区 医学 Q4 ENGINEERING, BIOMEDICAL Bio-medical materials and engineering Pub Date : 2024-01-01 DOI:10.3233/BME-230017
Rupan Yuan, Sijie Zhou, Xiong Xiong, Dan Yang, Donghu Lin, Taiyi Li, Bin He, Guihua Wei, Shuxin Qu
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引用次数: 0

摘要

背景:受天然骨骼的启发,许多有机成分被添加到磷酸钙水泥(CPC)中,以提高其机械强度。然而,这些复合 CPC 的强度受到有机成分本身强度低以及有机成分与 CPC 之间相互作用弱的限制:首先,开发了一种含有贻贝启发粘合剂聚多巴胺甲基丙烯酰胺-2-甲氧基乙基丙烯酸酯(pDM)的复合 CPC。其次,研究了 pDM 与 CPC 之间的相互作用及其对机械性能的影响:方法:采用核磁共振、激光拉曼、X 射线光电子能谱、傅立叶变换红外光谱和 X 射线衍射分析法研究 pDM 与 CPC 之间的相互作用:结果:pDM-CPC 支架的韧性和抗压强度均显著提高,这是由于 CPC 和 pDM 之间的相互作用增强了界面结合强度,而 pDM 的自氧化交联又提高了机械强度。pDM-CPC 支架的韧性随着 pDM 含量的增加而增加,而含有 35 wt.% pDM 的 pDM-CPC 支架的抗压强度最高,是 CPC 支架的五倍多:结论:机械强度高的 pDM-CPC 支架在骨再生以及颅面和骨科修复中具有潜在的应用价值。
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Enhanced mechanic properties of calcium phosphate cements via mussel-inspired adhesive as bone substitute: Highlights of their interactions.

Background: Inspired by natural bones, many organic components were added to Calcium Phosphate Cements (CPCs) to improve their mechanical strength. However, the strength of these composite CPCs is limited by the low strength of organic components itself and the weak interaction between organic components and CPCs.

Objective: Firstly, a composite CPC containing mussel-inspired adhesive, Poly-(Dopamine Methacrylamide-co-2-methoxy Ethylacrylate) (pDM) was developed. Secondly, the interactions between pDM and CPC and their effect on mechanical properties were investigated.

Methods: The interactions between pDM and CPC were performed by Nuclear Magnetic Resonance, Laser Raman, X-ray Photoelectron Spectroscopy, Fourier Transform-Infrared Spectroscopy and X-ray Diffraction Analysis.

Results: The toughness and compressive strength of pDM-CPC scaffold were both significantly enhanced, because of the enhanced interface binding strength among CPC and pDM due to their interaction and the improved mechanical strength of pDM owing to its self-oxidation cross-linking. The toughness of pDM-CPC scaffolds increased with the increased contents of pDM, while pDM-CPC scaffold containing 35 wt.% pDM had the highest compressive strength of all, which the latter was more than five times compared to that of CPC.

Conclusion: The mechanically strong pDM-CPC scaffolds has potential application in bone regeneration as well as in craniofacial and orthopedic repair.

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来源期刊
Bio-medical materials and engineering
Bio-medical materials and engineering 工程技术-材料科学:生物材料
CiteScore
1.80
自引率
0.00%
发文量
73
审稿时长
6 months
期刊介绍: The aim of Bio-Medical Materials and Engineering is to promote the welfare of humans and to help them keep healthy. This international journal is an interdisciplinary journal that publishes original research papers, review articles and brief notes on materials and engineering for biological and medical systems. Articles in this peer-reviewed journal cover a wide range of topics, including, but not limited to: Engineering as applied to improving diagnosis, therapy, and prevention of disease and injury, and better substitutes for damaged or disabled human organs; Studies of biomaterial interactions with the human body, bio-compatibility, interfacial and interaction problems; Biomechanical behavior under biological and/or medical conditions; Mechanical and biological properties of membrane biomaterials; Cellular and tissue engineering, physiological, biophysical, biochemical bioengineering aspects; Implant failure fields and degradation of implants. Biomimetics engineering and materials including system analysis as supporter for aged people and as rehabilitation; Bioengineering and materials technology as applied to the decontamination against environmental problems; Biosensors, bioreactors, bioprocess instrumentation and control system; Application to food engineering; Standardization problems on biomaterials and related products; Assessment of reliability and safety of biomedical materials and man-machine systems; and Product liability of biomaterials and related products.
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