妊娠早期血清HLA-G水平与先兆子痫发病的关系:一项系统综述和荟萃分析研究。

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2023-08-07 DOI:10.22074/ijfs.2023.559787.1349
Salome Maghsudlu, Mohamad Ghazanfari Hashemi, Vahid Talebi, Elham Vahabi, Sanaz Sharifpour, Ramtin Hajibeygi, Farajolah Maleki
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引用次数: 0

摘要

人类白细胞抗原G(HLA-G)水平是先兆子痫(PE)的生物标志物之一。本研究旨在确定妊娠初期母体血液中低可溶性HLA-G(sHLA-G)水平与随后PE之间的可能关系。我们检索了国际科学数据库Web of Science、Embase、PubMed、Cochrane和Scopus。我们使用适当的关键词提取了研究妊娠早期血清HLA-G水平与PE发病之间关系的研究。使用随机效应荟萃分析模型和STATA(第14版)对收集的数据进行分析。共有5项研究符合资格标准,总样本量为668名受试者。病例受试者的平均年龄和SD年龄为31.41±4.16岁,而对照受试者为30.56±3.5岁。根据研究结果,妊娠早期HLA-G血清水平与随后的PE发病呈负相关,标准平均差(SMD)=-1.51[95%置信区间(CI):-2.26,-0.75,I2=90.8%,P=0.000],并且sHLA-G在胎盘形成的早期阶段中的重要作用可以被证明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Association between Serum HLA-G Levels in The First Trimester of Pregnancy and The Onset of Preeclampsia: A Systematic Review and Meta-analysis Study.

Human leukocyte antigen G (HLA-G) levels are among the biomarkers suggested for pre-eclampsia (PE). This study is aimed at determining the possible relationship between low soluble HLA-G (sHLA-G) levels in maternal blood at the beginning of pregnancy and subsequent PE. We searched the international scientific databases of Web of Science, Embase, PubMed, Cochrane, and Scopus. We extracted the studies investigating the relationship between the serum levels of HLA-G in the first trimester of pregnancy and the onset of PE using the appropriate keywords. The collected data were analyzed using the random-effects meta-analysis model and STATA (version 14). A total of 5 studies met the eligibility criteria, and the total sample size was 668 subjects. The mean and SD age of case subjects was 31.41 ± 4.16 years, while it was 30.56 ± 3.5 for control subjects. According to the findings, there was an inverse relationship between HLA-G serum level in the first trimester of pregnancy and the subsequent onset of PE, standard mean difference (SMD)=-1.51 [95% confidence interval (CI): -2.26, -0.75, I2=90.8%, P=0.000]. Based on these results, low sHLA-G level in early pregnancy has a positive correlation with subsequent PE, and the significant role of sHLA-G in the early stages of placentation can be proven.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
68
审稿时长
>12 weeks
期刊介绍: International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.
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