注射后12小时血清人绒毛膜促性腺激素和体重指数预测体外受精卵母细胞成熟率：一项横断面研究。

IF 2.3 Q2 OBSTETRICS & GYNECOLOGY International Journal of Fertility & Sterility Pub Date : 2023-08-07 DOI:10.22074/ijfs.2023.555467.1315

Budi Wiweko, Ervan Surya, Vita Silvana, Mila Maidarti, Achmad Kemal Harzif, Gita Pratama, Kanadi Sumapraja, R Muharam, Andon Hestiantoro

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引用次数: 0

摘要

背景：体外受精（IVF）仍然是不孕病例的主要治疗方法。注射后人绒毛膜促性腺激素（hCG）水平是决定体外受精卵母细胞成熟率的重要因素。本研究旨在确定IVF参与者注射后12小时血清hCG水平与卵母细胞成熟率之间的关系。材料和方法：2020年1月至2021年12月，在印度尼西亚的一家三级医院对试管婴儿参与者进行了横断面研究。受试者皮下注射250μg重组人绒毛膜促性腺激素（r-hCG）。检索并分析注射后12小时血清hCG水平和卵母细胞成熟率数据。结果：28名受试者被纳入研究。注射后12小时血清hCG越高，卵母细胞成熟率越高（P=0.046）。注射后12 h血清hCG预测卵母细胞更好成熟率的临界点为90.15 mIU/mL（敏感性68.2%，特异性83.3%）。可通过体重指数（BMI）和注射后12 hCG预测卵子成熟率hCG与IVF受试者较高的卵母细胞成熟率相关。

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Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts In Vitro Fertilization Oocyte Maturation Rate: A Cross-Sectional Study.

Background: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants.

Materials and methods: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly.

Results: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG.

Conclusion: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects.

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来源期刊

International Journal of Fertility & Sterility 医学-妇产科学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.