Budi Wiweko, Ervan Surya, Vita Silvana, Mila Maidarti, Achmad Kemal Harzif, Gita Pratama, Kanadi Sumapraja, R Muharam, Andon Hestiantoro
{"title":"注射后12小时血清人绒毛膜促性腺激素和体重指数预测体外受精卵母细胞成熟率:一项横断面研究。","authors":"Budi Wiweko, Ervan Surya, Vita Silvana, Mila Maidarti, Achmad Kemal Harzif, Gita Pratama, Kanadi Sumapraja, R Muharam, Andon Hestiantoro","doi":"10.22074/ijfs.2023.555467.1315","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>In vitro</i> fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants.</p><p><strong>Materials and methods: </strong>A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly.</p><p><strong>Results: </strong>Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG.</p><p><strong>Conclusion: </strong>Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":null,"pages":null},"PeriodicalIF":2.3000,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/18/Int-J-Fertil-Steril-17-264.PMC10439995.pdf","citationCount":"0","resultStr":"{\"title\":\"Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts <i>In Vitro</i> Fertilization Oocyte Maturation Rate: A Cross-Sectional Study.\",\"authors\":\"Budi Wiweko, Ervan Surya, Vita Silvana, Mila Maidarti, Achmad Kemal Harzif, Gita Pratama, Kanadi Sumapraja, R Muharam, Andon Hestiantoro\",\"doi\":\"10.22074/ijfs.2023.555467.1315\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><i>In vitro</i> fertilization (IVF) remains a main treatment for infertility cases. 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Twelve Hours Post-Injection Serum Human Chorionic Gonadotropin and Body Mass Index Predicts In Vitro Fertilization Oocyte Maturation Rate: A Cross-Sectional Study.
Background: In vitro fertilization (IVF) remains a main treatment for infertility cases. Post-injection human chorionic gonadotropin (hCG) level is an essential factor in determining oocyte maturation rate in IVF. This study aimed to determine the relationship between 12 hours post-injection serum hCG level and oocyte maturation rate among IVF participants.
Materials and methods: A cross-sectional study on IVF participants was done at a tertiary hospital in Indonesia from January 2020 to December 2021. Subjects were injected with 250 μg of recombinant-hCG (r-hCG) subcutaneously. Twelve hours post-injection serum hCG levels and oocyte maturation rate data were retrieved and analyzed accordingly.
Results: Twenty-eight subjects were recruited into the study. Higher 12 hours post-injection serum hCG was related to oocyte maturation rate (P=0.046). The cut-off point of 12 hours post-injection serum hCG to predict better oocyte maturation rate was 90.15 mIU/mL (sensitivity 68.2%, specificity 83.3%). Oocyte maturation rate may be predicted using body mass index (BMI) and 12 hours post-injection serum hCG.
Conclusion: Higher 12 hours post-injection serum hCG was associated with a higher oocyte maturation rate in IVF subjects.
期刊介绍:
International Journal of Fertility & Sterility is a quarterly English publication of Royan Institute . The aim of the journal is to disseminate information through publishing the most recent scientific research studies on Fertility and Sterility and other related topics. Int J Fertil Steril has been certified by Ministry of Culture and Islamic Guidance in 2007 and was accredited as a scientific and research journal by HBI (Health and Biomedical Information) Journal Accreditation Commission in 2008. Int J Fertil Steril is an Open Access journal.