组织生物学:寻找新的范式。

IF 11.4 1区 生物学 Q1 CELL BIOLOGY Annual review of cell and developmental biology Pub Date : 2023-10-16 Epub Date: 2023-08-22 DOI:10.1146/annurev-cellbio-120420-113830
Miri Adler, Arun R Chavan, Ruslan Medzhitov
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引用次数: 0

摘要

动物组织由多种细胞类型组成,这些细胞类型的特征越来越明显,但我们对控制组织组织的核心原理的理解仍然不完整。这在一定程度上是因为许多可观察到的组织特征,如细胞组成和空间模式,都是涌现的特性,因此,它们不能仅通过单个细胞的知识来解释。在这里,我们提出了一个复杂系统理论的视角来解决我们对组织生物学理解中的这一根本差距。我们引入了细胞类别的概念,它基于细胞关系而不是细胞身份。基于这些概念,我们讨论了组织模块化的共同原则,介绍了组成、结构和功能组织模块。细胞多样性和细胞关系为研究健康和疾病中组织组织组织的基本原理提供了新的视角。
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Tissue Biology: In Search of a New Paradigm.

Animal tissues are made up of multiple cell types that are increasingly well-characterized, yet our understanding of the core principles that govern tissue organization is still incomplete. This is in part because many observable tissue characteristics, such as cellular composition and spatial patterns, are emergent properties, and as such, they cannot be explained through the knowledge of individual cells alone. Here we propose a complex systems theory perspective to address this fundamental gap in our understanding of tissue biology. We introduce the concept of cell categories, which is based on cell relations rather than cell identity. Based on these notions we then discuss common principles of tissue modularity, introducing compositional, structural, and functional tissue modules. Cell diversity and cell relations provide a basis for a new perspective on the underlying principles of tissue organization in health and disease.

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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
期刊最新文献
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