甘油三酯葡萄糖指数在急性心肌梗死患者中的预后价值。

IF 2.5 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiovascular Pharmacology and Therapeutics Pub Date : 2023-01-01 DOI:10.1177/10742484231181846
Qian Hao, Zhao Yuanyuan, Chen Lijuan
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引用次数: 1

摘要

目的:甘油三酯-葡萄糖(TyG)指数是一种简单可靠的胰岛素抵抗指标。最近的研究表明,TyG指数是心血管疾病的独立预测指标。然而,TyG指数对急性心肌梗死(AMI)患者的预后价值仍不确定。因此,本研究旨在评估TyG指数对AMI患者的预后价值。方法:对2018年至2020年入住中大医院的AMI患者进行连续入组。在筛选纳入标准后,1144名患者根据TyG指数分布的三分位数分为三组。患者作为门诊患者或通过电话联系患者,随访1年,并记录全因死亡的发生和时间。结果:急性心肌梗死患者的TyG指数与心力衰竭(HF)显著相关。TyG指数高的患者(第3组)(比值比:9.070,95%置信区间[CI]4.359-18.875,P<.001)的HF发生率明显高于TyG指数中等的患者(2组)。同样,在1年的随访中,第3组的全因死亡发生率显著高于第2组(危险比:2.996,95%CI 1.058-8.487,P = .039)。结论:TyG指数与HF密切相关,可能是预测AMI患者长期预后的一个有价值的指标。
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The Prognostic Value of the Triglyceride Glucose Index in Patients With Acute Myocardial Infarction.

Objective: The triglyceride-glucose (TyG) index is a simple and reliable surrogate for insulin resistance. Recent studies have suggested that the TyG index is an independent predictor of cardiovascular disease. However, the prognostic value of the TyG index in patients with acute myocardial infarction (AMI) remains uncertain. Thus, this study aimed to evaluate the prognostic value of the TyG index in patients with AMI. Methods: AMI patients admitted to Zhongda Hospital from 2018 to 2020 were successively enrolled. After screening the inclusion criteria, 1144 patients were divided into three groups according to the tertiles of the TyG index distribution. Patients were followed up for 1 year as outpatients or contacted via telephone, and the occurrence and timing of all-cause deaths were recorded. Results: The TyG index was significantly correlated with heart failure (HF) in AMI patients. Patients with a high TyG index (group 3) (odds ratio: 9.070, 95% confidence interval [CI] 4.359-18.875, P<.001) had a significantly higher incidence of HF compared with patients with median TyG index (group 2). Similarly, the incidence of all-cause death in group 3 was significantly higher than that in group 2 during the 1-year follow-up (hazard ratio: 2.996, 95% CI 1.058-8.487, P = .039). Conclusion: The TyG index is closely related to HF and may be a valuable indicator to predict the long-term prognosis of patients with AMI.

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来源期刊
CiteScore
6.00
自引率
0.00%
发文量
33
审稿时长
6-12 weeks
期刊介绍: Journal of Cardiovascular Pharmacology and Therapeutics (JCPT) is a peer-reviewed journal that publishes original basic human studies, animal studies, and bench research with potential clinical application to cardiovascular pharmacology and therapeutics. Experimental studies focus on translational research. This journal is a member of the Committee on Publication Ethics (COPE).
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