摩洛哥 SARS-CoV-2 Omicron 变体的遗传多样性和进化动态。

IF 4.9 4区 医学 Q1 PARASITOLOGY Pathogens and Global Health Pub Date : 2024-05-01 Epub Date: 2023-08-27 DOI:10.1080/20477724.2023.2250942
Safae El Mazouri, Abdelmounim Essabbar, Tarik Aanniz, Rachid Eljaoudi, Lahcen Belyamani, Azeddine Ibrahimi, Mouna Ouadghiri
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引用次数: 0

摘要

在全球已报道的严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)的众多变种中,Omicron 变种的出现极大地改变了冠状病毒病(COVID-19)大流行的格局。在此,我们分析了摩洛哥 SARS-CoV-2 基因组的遗传多样性,重点是摩洛哥发现 Omicron 变种一年后的情况,以了解其基因组动态、特征及其潜在的引入源。在 937 个 Omicron 基因组中,我们共发现了 999 个非独特变异,分布在 92 个 Omicron 系中,其中 13 个是摩洛哥特有的。我们的研究结果表明,摩洛哥的 Omicron 变异有多个引入源。此外,我们还发现,与其他 Omicron 支系相比,四个 Omicron 支系的传染性更强。值得注意的是,一个 Omicron 支系的传播性特别强,已成为全球的主要变种。此外,我们对受体结合域(RBD)突变的评估表明,Spike K444T 和 N460K 突变使该支系具有更强的免疫疫苗逃逸能力。总之,我们的分析凸显了摩洛哥 SARS-CoV-2 基因组中 Omicron 变体独特的遗传多样性,它有多个引种来源,并出现了高传播性支系。与全球菌株相比,摩洛哥菌株的独特性强调了持续监测和了解当地基因组动态对于在不断演变的 COVID-19 大流行中采取有效应对策略的重要性。
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Genetic diversity and evolutionary dynamics of the Omicron variant of SARS-CoV-2 in Morocco.

Among the numerous variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that have been reported worldwide, the emergence of the Omicron variant has drastically changed the landscape of the coronavirus disease (COVID-19) pandemic. Here, we analyzed the genetic diversity of Moroccan SARS-CoV-2 genomes with a focus on Omicron variant after one year of its detection in Morocco in order to understand its genomic dynamics, features and its potential introduction sources. From 937 Omicron genomes, we identified a total of 999 non-unique mutations distributed across 92 Omicron lineages, of which 13 were specific to the country. Our findings suggest multiple introductory sources of the Omicron variant to Morocco. In addition, we found that four Omicron clades are more infectious in comparison to other Omicron clades. Remarkably, a clade of Omicron is particularly more transmissible and has become the dominant variant worldwide. Moreover, our assessment of Receptor-Binding Domain (RBD) mutations showed that the Spike K444T and N460K mutations enabled a clade higher ability of immune vaccine escape. In conclusion, our analysis highlights the unique genetic diversity of the Omicron variant in Moroccan SARS-CoV-2 genomes, with multiple introductory sources and the emergence of highly transmissible clades. The distinctiveness of the Moroccan strains compared to global ones underscores the importance of ongoing surveillance and understanding of local genomic dynamics for effective response strategies in the evolving COVID-19 pandemic.

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来源期刊
Pathogens and Global Health
Pathogens and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-PARASITOLOGY
CiteScore
6.00
自引率
0.00%
发文量
60
审稿时长
6-12 weeks
期刊介绍: Pathogens and Global Health is a journal of infectious disease and public health that focuses on the translation of molecular, immunological, genomics and epidemiological knowledge into control measures for global health threat. The journal publishes original innovative research papers, reviews articles and interviews policy makers and opinion leaders on health subjects of international relevance. It provides a forum for scientific, ethical and political discussion of new innovative solutions for controlling and eradicating infectious diseases, with particular emphasis on those diseases affecting the poorest regions of the world.
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