Yao Chen, Quanyao Chen, Can Cai, Xiuxian Lin, Weiwei Yu, Huiqiong Huang, Wenmin Xie, Min Lin, Weida Chen, Hui Wu, Tingting Su, Lingsong Wang
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引用次数: 0
摘要
背景：本研究探讨了COMT G1947A和OPRM1 A118G多态性作为舒芬太尼硬膜外镇痛预测标志物的应用。方法：采用视觉模拟量表（VAS）评分和136对舒芬太尼联合利多卡因和罗哌卡因硬膜外镇痛产妇的舒芬太尼用量进行分析。结果：与AA携带者相比，OPRM1AG/GG在第5分钟和第0分钟的VAS评分差异较低（1.55 vs 1.87；p=0.012），消耗量较高（19.65μg vs 17.11μg；p=0.049）。结论：舒芬太尼对OPRM1-AA和COMT-GA/AA的硬膜外分娩镇痛效果优于OPRM1-AG/GG和COMT-GG。临床试验注册：ChiCTR1900026897（中国临床试验中心注册处）。
Effect of OPRM1/COMT gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching.
Background: This study investigated the use of COMT G1947A and OPRM1 A118G polymorphisms as predictive markers for sufentanil epidural analgesia. Methods: The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. Results:OPRM1 AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers. COMT GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). Conclusion: Sufentanil may provide better epidural labor analgesia in OPRM1 AA and COMT GA/AA carriers compared with OPRM1 AG/GG and COMT GG carriers. Clinical Trial Registration: ChiCTR1900026897 (Chinese Clinical Trial Center Registry).
期刊介绍：
Pharmacogenomics (ISSN 1462-2416) is a peer-reviewed journal presenting reviews and reports by the researchers and decision-makers closely involved in this rapidly developing area. Key objectives are to provide the community with an essential resource for keeping abreast of the latest developments in all areas of this exciting field.
Pharmacogenomics is the leading source of commentary and analysis, bringing you the highest quality expert analyses from corporate and academic opinion leaders in the field.
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