{"title":"依达拉奉和诺卡平对白化 Wistar 大鼠行为和神经系统的影响","authors":"Mamsa Rumaiza Hafizur Rehman, Angel Pavalu Godad, Gaurav Mahesh Doshi","doi":"10.1080/0361073X.2023.2250227","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the study was to explore Edaravone and Noscapine in anAlCl3-induced Alzheimer's disease (AD) model.</p><p><strong>Methods: </strong>Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology.</p><p><strong>Results: </strong>On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant. The NOR showeddiscrimination and recognition index scores and Y-maze, revealed arise in spontaneous alterations. TNF-α, IL-1, IL-6, amyloid-β, CATand MDA levels increased, while SOD levels dropped. The results werefound to be significant for combination full and half doses (***<i>p</i> <0.001, **<i>p</i> < 0.01). The treated group's histology ofbrain revealed mild neurodegeneration with hippocampal pyknoticnuclei.</p><p><strong>Conclusions: </strong>Thus, Edaravone and Noscapine can be used for thetreatment of AD. .</p>","PeriodicalId":12240,"journal":{"name":"Experimental Aging Research","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Behavioral and Neurological Effects of Edaravone and Noscapine in Albino Wistar Rats.\",\"authors\":\"Mamsa Rumaiza Hafizur Rehman, Angel Pavalu Godad, Gaurav Mahesh Doshi\",\"doi\":\"10.1080/0361073X.2023.2250227\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The purpose of the study was to explore Edaravone and Noscapine in anAlCl3-induced Alzheimer's disease (AD) model.</p><p><strong>Methods: </strong>Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology.</p><p><strong>Results: </strong>On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant. The NOR showeddiscrimination and recognition index scores and Y-maze, revealed arise in spontaneous alterations. TNF-α, IL-1, IL-6, amyloid-β, CATand MDA levels increased, while SOD levels dropped. The results werefound to be significant for combination full and half doses (***<i>p</i> <0.001, **<i>p</i> < 0.01). The treated group's histology ofbrain revealed mild neurodegeneration with hippocampal pyknoticnuclei.</p><p><strong>Conclusions: </strong>Thus, Edaravone and Noscapine can be used for thetreatment of AD. .</p>\",\"PeriodicalId\":12240,\"journal\":{\"name\":\"Experimental Aging Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental Aging Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/0361073X.2023.2250227\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/8/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental Aging Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/0361073X.2023.2250227","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/24 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
研究目的研究目的：探讨依达拉奉和诺卡平在AlCl3诱导的阿尔茨海默病（AD）模型中的作用：方法：进行莫里斯水迷宫（MWM）、新物体识别（NOR）和Y迷宫测试，并检测TNF-α、IL-1、IL-6、淀粉样蛋白-β、CAT、SOD和MDA水平，然后进行脑组织学检查：在探究试验中，MWM 表现出逃避潜伏期缩短，随后目标象限增加。NOR显示了分辨和识别指数得分，Y-迷宫显示了自发改变。TNF-α、IL-1、IL-6、淀粉样蛋白-β、CAT和MDA水平升高，而SOD水平下降。结果表明，全剂量和半剂量联合治疗效果显著（***p p < 0.01）。处理组的脑组织学显示轻度神经变性，海马出现凋亡核：因此，依达拉奉和诺卡平可用于治疗AD。.
Behavioral and Neurological Effects of Edaravone and Noscapine in Albino Wistar Rats.
Objective: The purpose of the study was to explore Edaravone and Noscapine in anAlCl3-induced Alzheimer's disease (AD) model.
Methods: Morris Water Maze (MWM), Novel Object Recognition (NOR), andY-maze tests with TNF-α, IL-1, IL-6, amyloid-β, CAT, SOD and MDAlevels were performed, followed by brain histology.
Results: On the probe trial, the MWM demonstrated a decrease in escape latencyfollowed by an increase in the target quadrant. The NOR showeddiscrimination and recognition index scores and Y-maze, revealed arise in spontaneous alterations. TNF-α, IL-1, IL-6, amyloid-β, CATand MDA levels increased, while SOD levels dropped. The results werefound to be significant for combination full and half doses (***p <0.001, **p < 0.01). The treated group's histology ofbrain revealed mild neurodegeneration with hippocampal pyknoticnuclei.
Conclusions: Thus, Edaravone and Noscapine can be used for thetreatment of AD. .
期刊介绍：
Experimental Aging Research is a life span developmental and aging journal dealing with research on the aging process from a psychological and psychobiological perspective. It meets the need for a scholarly journal with refereed scientific papers dealing with age differences and age changes at any point in the adult life span. Areas of major focus include experimental psychology, neuropsychology, psychobiology, work research, ergonomics, and behavioral medicine. Original research, book reviews, monographs, and papers covering special topics are published.
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