裂谷热病毒神经发病机制的研究进展

IF 8.1 1区 医学 Q1 VIROLOGY Annual Review of Virology Pub Date : 2022-09-29 DOI:10.1146/annurev-virology-091919-065806
Kaleigh A Connors, Amy L Hartman
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引用次数: 10

摘要

裂谷热病毒(RVFV)是一种新出现的虫媒病毒病原体,可在牲畜和人类中引起疾病。裂谷热(RVF)在人类中的严重疾病表现包括出血热、眼病和脑炎。本文综述了目前对裂谷热脑炎发病机制的了解。虽然存在一些来自人类研究的数据,但几种动物模型的发展加速了对裂谷热病毒神经发病机制的研究。我们回顾了目前的动物模型并讨论了它们教给我们的关于裂谷热病毒脑炎的知识。我们简要描述了用于研究其他嗜神经虫媒病毒的替代模型,以及这些模型如何有助于我们了解裂谷热病毒脑炎。最后,我们提出了一些悬而未决的问题和未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Advances in Understanding Neuropathogenesis of Rift Valley Fever Virus.
Rift Valley fever virus (RVFV) is an emerging arboviral pathogen that causes disease in both livestock and humans. Severe disease manifestations of Rift Valley fever (RVF) in humans include hemorrhagic fever, ocular disease, and encephalitis. This review describes the current understanding of the pathogenesis of RVF encephalitis. While some data from human studies exist, the development of several animal models has accelerated studies of the neuropathogenesis of RVFV. We review current animal models and discuss what they have taught us about RVFV encephalitis. We briefly describe alternative models that have been used to study other neurotropic arboviruses and how these models may help contribute to our understanding RVFV encephalitis. We conclude with some unanswered questions and future directions.
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来源期刊
CiteScore
19.40
自引率
0.90%
发文量
28
期刊介绍: The Annual Review of Virology serves as a conduit for disseminating thrilling advancements in our comprehension of viruses spanning animals, plants, bacteria, archaea, fungi, and protozoa. Its reviews illuminate novel concepts and trajectories in basic virology, elucidating viral disease mechanisms, exploring virus-host interactions, and scrutinizing cellular and immune responses to virus infection. These reviews underscore the exceptional capacity of viruses as potent probes for investigating cellular function.
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