{"title":"[噬菌体与肠道菌群的相互作用及其在炎性肠病中的研究进展]。","authors":"X T Shen, Z Z Zhao, X L Zhang","doi":"10.3760/cma.j.cn112138-20221020-00770","DOIUrl":null,"url":null,"abstract":"炎症性肠病(IBD)是一种自身炎症性疾病,包括溃疡性结肠炎(UC)、克罗恩病(CD)和未定型结肠炎(IC)。由于炎症性肠病的早期症状并不典型,难以早发现,并且临床上难以治愈,因此寻找炎症性肠病的新型治疗手段成为重点。近年来,研究表明肠道菌群与IBD在疾病发生发展中互相影响,例如肠道菌群失调可以加重肠道黏膜损伤,调节肠道免疫反应,引发肠道慢性炎症。而肠道慢性炎症又会影响肠道菌群,加重菌群失调。因此,治疗肠道菌群失调显得尤为重要。噬菌体因为其可以作用于肠道菌群而进入人们的视线,由于其高效性、易获取、可以裂解细菌结构等特性,近年来噬菌体与细菌如何相互作用、能否成为IBD新的治疗手段成为研究热点,本文就噬菌体与肠道菌群的相互作用及其在IBD中的研究进展进行综述。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 9","pages":"1144-1147"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The interaction between phage and intestinal flora and related research progress in inflammatory bowel disease].\",\"authors\":\"X T Shen, Z Z Zhao, X L Zhang\",\"doi\":\"10.3760/cma.j.cn112138-20221020-00770\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"炎症性肠病(IBD)是一种自身炎症性疾病,包括溃疡性结肠炎(UC)、克罗恩病(CD)和未定型结肠炎(IC)。由于炎症性肠病的早期症状并不典型,难以早发现,并且临床上难以治愈,因此寻找炎症性肠病的新型治疗手段成为重点。近年来,研究表明肠道菌群与IBD在疾病发生发展中互相影响,例如肠道菌群失调可以加重肠道黏膜损伤,调节肠道免疫反应,引发肠道慢性炎症。而肠道慢性炎症又会影响肠道菌群,加重菌群失调。因此,治疗肠道菌群失调显得尤为重要。噬菌体因为其可以作用于肠道菌群而进入人们的视线,由于其高效性、易获取、可以裂解细菌结构等特性,近年来噬菌体与细菌如何相互作用、能否成为IBD新的治疗手段成为研究热点,本文就噬菌体与肠道菌群的相互作用及其在IBD中的研究进展进行综述。.\",\"PeriodicalId\":24000,\"journal\":{\"name\":\"Zhonghua nei ke za zhi\",\"volume\":\"62 9\",\"pages\":\"1144-1147\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhonghua nei ke za zhi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn112138-20221020-00770\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20221020-00770","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}