{"title":"补充博氏酵母CNCM I-1079对日本黑犊牛对一种灭活细菌疫苗反应的影响:一项田间试验","authors":"Kazusa Mori, Asato Uchiumi, Kai Yamamoto, Yuki Shimizu, Risa Ueda, Keigo Kosenda, Tomochika Fukuhara, Syunsuke Kure, Hiroyuki Fukazawa, Hiromichi Ohtsuka","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p><i>Saccharomyces boulardii</i> group (SB group) calves were fed 2.0 × 10<sup>10</sup> CFU/day of <i>S. boulardii</i> in milk replacer after 2 wk of age. All calves received inactivated vaccine for <i>Histophilus somni, Pasteurella multocida</i>, and <i>Mannheimia haemolytica</i> at 3 wk of age and 3 wk later. After vaccination, the SB group calves showed significantly higher (mean difference: 1.56-fold) antibody titer against <i>H. somni</i> than the control group. The number of calves with the antibody titer above the cut-off value for <i>M. haemolytica</i> of the SB group was significantly higher than that of the control, and the percentage was twice as high. In addition, the mRNA transcription of <i>IL4</i> and <i>IL10</i> in peripheral blood mononuclear cells at the booster of the SB group was significantly higher than those of the control. In conclusion, <i>S. boulardii</i> may have positively affected immune responses to the inactivated multi-bacterial vaccine in young calves in the field.</p>","PeriodicalId":9550,"journal":{"name":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","volume":"87 3","pages":"237-242"},"PeriodicalIF":1.1000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291731/pdf/","citationCount":"0","resultStr":"{\"title\":\"Effect of supplementation with <i>Saccharomyces boulardii</i> CNCM I-1079 on vaccine response to an inactivated bacterial vaccine in young Japanese Black calves: A field trial.\",\"authors\":\"Kazusa Mori, Asato Uchiumi, Kai Yamamoto, Yuki Shimizu, Risa Ueda, Keigo Kosenda, Tomochika Fukuhara, Syunsuke Kure, Hiroyuki Fukazawa, Hiromichi Ohtsuka\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Saccharomyces boulardii</i> group (SB group) calves were fed 2.0 × 10<sup>10</sup> CFU/day of <i>S. boulardii</i> in milk replacer after 2 wk of age. All calves received inactivated vaccine for <i>Histophilus somni, Pasteurella multocida</i>, and <i>Mannheimia haemolytica</i> at 3 wk of age and 3 wk later. After vaccination, the SB group calves showed significantly higher (mean difference: 1.56-fold) antibody titer against <i>H. somni</i> than the control group. The number of calves with the antibody titer above the cut-off value for <i>M. haemolytica</i> of the SB group was significantly higher than that of the control, and the percentage was twice as high. In addition, the mRNA transcription of <i>IL4</i> and <i>IL10</i> in peripheral blood mononuclear cells at the booster of the SB group was significantly higher than those of the control. In conclusion, <i>S. boulardii</i> may have positively affected immune responses to the inactivated multi-bacterial vaccine in young calves in the field.</p>\",\"PeriodicalId\":9550,\"journal\":{\"name\":\"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire\",\"volume\":\"87 3\",\"pages\":\"237-242\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10291731/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Veterinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian journal of veterinary research = Revue canadienne de recherche veterinaire","FirstCategoryId":"97","ListUrlMain":"","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Veterinary","Score":null,"Total":0}
Effect of supplementation with Saccharomyces boulardii CNCM I-1079 on vaccine response to an inactivated bacterial vaccine in young Japanese Black calves: A field trial.
Saccharomyces boulardii group (SB group) calves were fed 2.0 × 1010 CFU/day of S. boulardii in milk replacer after 2 wk of age. All calves received inactivated vaccine for Histophilus somni, Pasteurella multocida, and Mannheimia haemolytica at 3 wk of age and 3 wk later. After vaccination, the SB group calves showed significantly higher (mean difference: 1.56-fold) antibody titer against H. somni than the control group. The number of calves with the antibody titer above the cut-off value for M. haemolytica of the SB group was significantly higher than that of the control, and the percentage was twice as high. In addition, the mRNA transcription of IL4 and IL10 in peripheral blood mononuclear cells at the booster of the SB group was significantly higher than those of the control. In conclusion, S. boulardii may have positively affected immune responses to the inactivated multi-bacterial vaccine in young calves in the field.
期刊介绍：
The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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