{"title":"胰岛β细胞再生:糖尿病治疗的机遇与挑战。","authors":"J Li, R Wei, T P Hong","doi":"10.3760/cma.j.cn112138-20230309-00144","DOIUrl":null,"url":null,"abstract":"恢复功能性胰岛β细胞数量（β细胞再生）是治疗糖尿病的重要策略。诱导干细胞定向分化、促进体细胞重编程、修复原有β细胞表型和功能是促进β细胞再生的重要路径，有望改变糖尿病的自然病程。然而，目前大多数干预方案面临β细胞再生效率低、难以获得功能完全成熟的β细胞、安全性尚待检验等挑战，未来需要进一步优化干预方案，并积累高质量的临床研究证据。.","PeriodicalId":24000,"journal":{"name":"Zhonghua nei ke za zhi","volume":"62 9","pages":"1046-1051"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Pancreatic β cell regeneration: the opportunities and challenges in diabetes therapies].\",\"authors\":\"J Li, R Wei, T P Hong\",\"doi\":\"10.3760/cma.j.cn112138-20230309-00144\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"恢复功能性胰岛β细胞数量（β细胞再生）是治疗糖尿病的重要策略。诱导干细胞定向分化、促进体细胞重编程、修复原有β细胞表型和功能是促进β细胞再生的重要路径，有望改变糖尿病的自然病程。然而，目前大多数干预方案面临β细胞再生效率低、难以获得功能完全成熟的β细胞、安全性尚待检验等挑战，未来需要进一步优化干预方案，并积累高质量的临床研究证据。.\",\"PeriodicalId\":24000,\"journal\":{\"name\":\"Zhonghua nei ke za zhi\",\"volume\":\"62 9\",\"pages\":\"1046-1051\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhonghua nei ke za zhi\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/cma.j.cn112138-20230309-00144\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua nei ke za zhi","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/cma.j.cn112138-20230309-00144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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