RNA2Immune:一个实验支持的数据数据库,将非编码RNA调节与免疫系统联系起来。

IF 11.5 2区 生物学 Q1 GENETICS & HEREDITY Genomics, Proteomics & Bioinformatics Pub Date : 2023-04-01 DOI:10.1016/j.gpb.2022.05.001
Jianjian Wang , Shuang Li , Tianfeng Wang , Si Xu , Xu Wang , Xiaotong Kong , Xiaoyu Lu , Huixue Zhang , Lifang Li , Meng Feng , Shangwei Ning , Lihua Wang
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引用次数: 2

摘要

非编码RNA(ncRNA),如微小RNA(miRNA)、长非编码RNA和环状RNA(circRNA),已成为免疫系统的重要调节因子,并参与免疫细胞生物学、疾病发病机制和疫苗反应的控制。ncRNA免疫关联库将有助于我们理解免疫系统中的ncRNA依赖性机制,并促进免疫疾病的治疗和预防的发展。在此,我们描述了一个综合数据库RNA2Immune,旨在提供一个高质量的实验支持数据库资源,将ncRNA调节机制与免疫细胞功能、免疫疾病、癌症免疫学和疫苗联系起来。RNA2Immune的当前版本记录了42个宿主物种中的50433个免疫ncRNA关联,包括(1)6690个具有免疫功能的ncRNA关联涉及31种免疫细胞类型;(2) 38672个ncRNA与348种免疫性疾病相关;(3) 4833个ncRNA与癌症免疫学的相关性;和(4)238个ncRNA与疫苗反应的关联,涉及针对22种疾病的26种疫苗类型。RNA2Immune提供了一个用户友好的界面,用于浏览、搜索和下载ncRNA免疫系统关联。总的来说,RNA2Immune提供了关于ncRNA如何影响免疫细胞功能、这些ncRNA的失调如何导致病理后果(免疫疾病和癌症)以及ncRNAs如何影响对疫苗的免疫反应的重要信息。RNA2Immune可在http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp.
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RNA2Immune: A Database of Experimentally Supported Data Linking Non-coding RNA Regulation to The Immune System

Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), have emerged as important regulators of the immune system and are involved in the control of immune cell biology, disease pathogenesis, as well as vaccine responses. A repository of ncRNA–immune associations will facilitate our understanding of ncRNA-dependent mechanisms in the immune system and advance the development of therapeutics and prevention for immune disorders. Here, we describe a comprehensive database, RNA2Immune, which aims to provide a high-quality resource of experimentally supported database linking ncRNA regulatory mechanisms to immune cell function, immune disease, cancer immunology, and vaccines. The current version of RNA2Immune documents 50,433 immune–ncRNA associations in 42 host species, including (1) 6690 ncRNA associations with immune functions involving 31 immune cell types; (2) 38,672 ncRNA associations with 348 immune diseases; (3) 4833 ncRNA associations with cancer immunology; and (4) 238 ncRNA associations with vaccine responses involving 26 vaccine types targeting 22 diseases. RNA2Immune provides a user-friendly interface for browsing, searching, and downloading ncRNA–immune system associations. Collectively, RNA2Immune provides important information about how ncRNAs influence immune cell function, how dysregulation of these ncRNAs leads to pathological consequences (immune diseases and cancers), and how ncRNAs affect immune responses to vaccines. RNA2Immune is available at http://bio-bigdata.hrbmu.edu.cn/rna2immune/home.jsp.

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来源期刊
Genomics, Proteomics & Bioinformatics
Genomics, Proteomics & Bioinformatics Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
14.30
自引率
4.20%
发文量
844
审稿时长
61 days
期刊介绍: Genomics, Proteomics and Bioinformatics (GPB) is the official journal of the Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation and Genetics Society of China. It aims to disseminate new developments in the field of omics and bioinformatics, publish high-quality discoveries quickly, and promote open access and online publication. GPB welcomes submissions in all areas of life science, biology, and biomedicine, with a focus on large data acquisition, analysis, and curation. Manuscripts covering omics and related bioinformatics topics are particularly encouraged. GPB is indexed/abstracted by PubMed/MEDLINE, PubMed Central, Scopus, BIOSIS Previews, Chemical Abstracts, CSCD, among others.
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