乳腺涎腺样肿瘤。

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY Archives of pathology & laboratory medicine Pub Date : 2023-09-01 DOI:10.5858/arpa.2023-0038-RA
Edward T Richardson, Vickie Y Jo, Stuart J Schnitt
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引用次数: 0

摘要

背景:世界卫生组织对乳腺肿瘤的分类识别了几种特殊类型的癌和良性病变,其特征与唾液腺肿瘤相似。目的:探讨乳腺涎腺样癌的组织学、免疫表型、分子及临床特征。这些乳腺肿瘤通常是激素受体和人表皮生长因子受体2 (HER2)阴性,即三阴性,但通常比无特殊类型的三阴性乳腺癌预后好得多。我们比较了这些乳腺肿瘤与唾液腺肿瘤的免疫表型、分子和临床特征,突出了相似性和差异性。我们也讨论良性涎腺样乳腺肿瘤。最后,我们强调了在了解这些乳腺肿瘤的分子发病机制和新的辅助研究方面的最新进展,这些研究可用于支持其诊断。资料来源:通过文献综述,根据论文的新颖性、适用性和在该领域的影响力,选择论文进行进一步的分析和讨论。结论:乳腺肿瘤与唾液腺肿瘤在形态上的重叠已经被病理学家发现了几十年,但直到最近才了解它们在分子发病机制上的异同。这些发展导致了新的诊断工具和进一步了解这些罕见的乳腺病变。
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Salivary Gland-like Tumors of the Breast.

Context: The World Health Organization classification of tumors of the breast recognizes several special type carcinomas and benign lesions with features comparable to those of salivary gland tumors.

Objective: To discuss the histologic, immunophenotypic, molecular, and clinical features of salivary gland-like carcinomas of the breast. These breast tumors are often negative for hormone receptors and human epidermal growth factor receptor 2 (HER2), that is, triple-negative, but they generally have a much better prognosis than triple-negative breast carcinomas of no special type. We compare the immunophenotypic, molecular, and clinical features of these breast tumors with their salivary gland counterparts, highlighting similarities and differences. We also discuss benign salivary gland-like breast tumors. Finally, we highlight recent developments in understanding the molecular pathogenesis of these breast tumors and novel ancillary studies that can be used to support their diagnosis.

Data sources: A literature review was conducted, and papers were selected for further analysis and discussion by the authors of this review based on their novelty, applicability, and impact in the field.

Conclusions: Breast tumors that exhibit morphologic overlap with salivary gland tumors have been recognized by pathologists for decades, but the similarities and differences in their molecular pathogenesis have not been understood until more recently. These developments have led to novel diagnostic tools and further knowledge of these rare breast lesions.

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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
期刊最新文献
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