Philipp Rassek, Michael Schäfers, Kambiz Rahbar, Philipp Backhaus
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For determination of split renal function in PSMA-PET/CT, we evaluated the relative unilateral total renal PSMA uptake, i.e. SUV<sub>mean</sub> multiplied by the renal volume (SRF<sub>PSMA-TOTAL</sub>) and relative unilateral maximal standardized uptake value (SRF<sub>SUV</sub>). These were compared to MAG3 split renal function (SRF<sub>MAG3</sub>) using Pearson correlation and receiver operating characteristics analysis. For determination of global renal function, correlation of bilateral total renal PSMA uptake with MAG3 tubular excretion rate and serum creatinine was assessed.</p><p><strong>Results: </strong>SRF<sub>MAG3</sub> was strongly correlated with SRF<sub>PSMA-TOTAL</sub> (r= 0.872, p<0.001) and with SRF<sub>SUV</sub> (r=0.815, p<0.001). Relevant abnormalities of SRF<sub>MAG3</sub> (unilateral renal function < 25 %) could be detected with sensitivities and specificities of 90% and 92% for SRF<sub>PSMA-TOTAL</sub>, and 80% and 95% for SRF<sub>SUV</sub>. Measures of absolute renal function were only weakly correlated with bilateral total renal PSMA uptake.</p><p><strong>Conclusion: </strong>Renal [<sup>18</sup>F]-PSMA-1007 uptake allowed to quantify renal split function with good accuracy based on SRF<sub>PSMA-TOTAL</sub> or SRF<sub>SUV</sub>.</p>","PeriodicalId":19238,"journal":{"name":"Nuklearmedizin-nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[18F]-PSMA-1007-PET for evaluation of kidney function.\",\"authors\":\"Philipp Rassek, Michael Schäfers, Kambiz Rahbar, Philipp Backhaus\",\"doi\":\"10.1055/a-2127-7880\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Prostate-specific membrane antigen (PSMA) is present in the proximal tubule cells of the kidneys. This results in high renal tracer uptake in PSMA-PET, which may contain useful information on renal function. As part of the evaluation for [<sup>177</sup>Lu]-PSMA therapies, patients undergo PSMA-PET and additional [<sup>99m</sup>Tc]-mercapto-acetyltriglycine (MAG3) scintigraphy to assess renal function. Aim of this study was to evaluate estimation of renal function with [<sup>18</sup>F]-PSMA-1007-PET/CT (PSMA-PET) by comparison to timely MAG3-scintigraphies.</p><p><strong>Materials and methods: </strong>We retrospectively investigated 73 prostate cancer patients with 93 timely available PSMA-PET/CT, MAG3-scintigraphies and serum creatinine. For determination of split renal function in PSMA-PET/CT, we evaluated the relative unilateral total renal PSMA uptake, i.e. SUV<sub>mean</sub> multiplied by the renal volume (SRF<sub>PSMA-TOTAL</sub>) and relative unilateral maximal standardized uptake value (SRF<sub>SUV</sub>). 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引用次数: 0
摘要
目的:前列腺特异性膜抗原(PSMA)存在于肾脏近端小管细胞中。这导致PSMA-PET的高肾示踪剂摄取，这可能包含肾功能的有用信息。作为评估[177Lu]-PSMA疗法的一部分，患者接受PSMA-PET和额外的[99mTc]-巯基-乙酰甘油三酯(MAG3)显像来评估肾功能。本研究的目的是评估[18F]-PSMA-1007-PET/CT (PSMA-PET)对肾功能的估计，并与及时的mag3闪烁图进行比较。材料与方法:回顾性分析73例前列腺癌患者93例及时获得的PSMA-PET/CT、mag3显像和血清肌酐。为了确定PSMA- pet /CT中的分裂肾功能，我们评估了相对单侧肾脏PSMA总摄取，即SUVmean乘以肾脏体积(SRFPSMA-TOTAL)和相对单侧最大标准化摄取值(SRFSUV)。使用Pearson相关性和受试者工作特征分析将这些与MAG3分裂肾功能(SRFMAG3)进行比较。为了确定整体肾功能，评估双侧肾总PSMA摄取与MAG3小管排泄率和血清肌酐的相关性。结果:SRFMAG3与SRFPSMA-TOTAL (r= 0.872)、pSUV (r=0.815)呈正相关，pMAG3(单侧肾功能< 25%)检测SRFPSMA-TOTAL的敏感性和特异性分别为90%和92%，SRFSUV的敏感性和特异性分别为80%和95%。绝对肾功能指标与双侧肾PSMA摄取总量仅呈弱相关。结论:基于SRFPSMA-TOTAL或SRFSUV，肾[18F]-PSMA-1007摄取能够以较好的准确性量化肾分裂功能。
[18F]-PSMA-1007-PET for evaluation of kidney function.
Purpose: Prostate-specific membrane antigen (PSMA) is present in the proximal tubule cells of the kidneys. This results in high renal tracer uptake in PSMA-PET, which may contain useful information on renal function. As part of the evaluation for [177Lu]-PSMA therapies, patients undergo PSMA-PET and additional [99mTc]-mercapto-acetyltriglycine (MAG3) scintigraphy to assess renal function. Aim of this study was to evaluate estimation of renal function with [18F]-PSMA-1007-PET/CT (PSMA-PET) by comparison to timely MAG3-scintigraphies.
Materials and methods: We retrospectively investigated 73 prostate cancer patients with 93 timely available PSMA-PET/CT, MAG3-scintigraphies and serum creatinine. For determination of split renal function in PSMA-PET/CT, we evaluated the relative unilateral total renal PSMA uptake, i.e. SUVmean multiplied by the renal volume (SRFPSMA-TOTAL) and relative unilateral maximal standardized uptake value (SRFSUV). These were compared to MAG3 split renal function (SRFMAG3) using Pearson correlation and receiver operating characteristics analysis. For determination of global renal function, correlation of bilateral total renal PSMA uptake with MAG3 tubular excretion rate and serum creatinine was assessed.
Results: SRFMAG3 was strongly correlated with SRFPSMA-TOTAL (r= 0.872, p<0.001) and with SRFSUV (r=0.815, p<0.001). Relevant abnormalities of SRFMAG3 (unilateral renal function < 25 %) could be detected with sensitivities and specificities of 90% and 92% for SRFPSMA-TOTAL, and 80% and 95% for SRFSUV. Measures of absolute renal function were only weakly correlated with bilateral total renal PSMA uptake.
Conclusion: Renal [18F]-PSMA-1007 uptake allowed to quantify renal split function with good accuracy based on SRFPSMA-TOTAL or SRFSUV.
期刊介绍：
Als Standes- und Fachorgan (Organ von Deutscher Gesellschaft für Nuklearmedizin (DGN), Österreichischer Gesellschaft für Nuklearmedizin und Molekulare Bildgebung (ÖGN), Schweizerischer Gesellschaft für Nuklearmedizin (SGNM, SSNM)) von hohem wissenschaftlichen Anspruch befasst sich die CME-zertifizierte Nuklearmedizin/ NuclearMedicine mit Diagnostik und Therapie in der Nuklearmedizin und dem Strahlenschutz: Originalien, Übersichtsarbeiten, Referate und Kongressberichte stellen aktuelle Themen der Diagnose und Therapie dar.
Ausführliche Berichte aus den DGN-Arbeitskreisen, Nachrichten aus Forschung und Industrie sowie Beschreibungen innovativer technischer Geräte, Einrichtungen und Systeme runden das Konzept ab.
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Nuklearmedizin erscheint regelmäßig mit sechs Ausgaben pro Jahr und richtet sich vor allem an Nuklearmediziner, Radiologen, Strahlentherapeuten, Medizinphysiker und Radiopharmazeuten.
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