美国聚氯乙烯检查手套中的接触过敏原分析。

IF 4 3区 医学 Q1 DERMATOLOGY Dermatitis Pub Date : 2024-03-01 Epub Date: 2023-09-05 DOI:10.1089/derm.2023.0150
Thomas Norman, Jana Guenther, Isaac Asante, Brandon L Adler
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引用次数: 0

摘要

背景:建议将聚氯乙烯(PVC)手套作为橡胶促进剂过敏患者的安全替代品。然而,也有报道称聚氯乙烯手套中的其他化学物质会引起过敏性接触性皮炎。研究目的分析美国一次性使用的聚氯乙烯医用检查手套中是否存在潜在的接触性过敏原。方法:采用液相色谱-质谱法:使用液相色谱-质谱法,对 20 只一式三份的 PVC 手套中的 6 种化学物质进行分析:苯并异噻唑啉酮、双酚 A、马来酸单(2-乙基己基)酯、磷酸三甲苯酯、磷酸三苯酯和亚磷酸三苯酯。检测结果:所有 20 只 PVC 手套都含有可检测到的苯并异噻唑啉酮(含量范围为 0.001-1.48 百万分之一 [ppm])、双酚 A(0.01-0.11 ppm)、磷酸三苯酯(0.01-2.11 ppm)和亚磷酸三苯酯(0.001-0.22 ppm)。18 个手套(90%)含有马来酸单(2-乙基己酯)(0.001-0.14 ppm),3 个手套(15%)含有磷酸三甲苯酯(0.001-0.002 ppm)。结论:所有 20 种 PVC 手套中都含有已知的过敏原。不过,检测到的含量大多较低,它们与致敏性和激发阈值之间的关系还需要进一步研究。
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Analysis of Contact Allergens in Polyvinyl Chloride Examination Gloves in the United States.

Background: Polyvinyl chloride (PVC) gloves are recommended as a safe alternative for patients with rubber accelerator allergy. However, allergic contact dermatitis to other chemicals in PVC gloves has been reported. Objective: To analyze single-use PVC medical examination gloves in the United States for the presence of potential contact allergens. Methods: Using liquid chromatography-mass spectrometry, 20 unique PVC gloves were analyzed in triplicate for 6 chemicals: benzisothiazolinone, bisphenol A, mono(2-ethylhexyl) maleate, tricresyl phosphate, triphenyl phosphate, and triphenyl phosphite. Results: All 20 PVC gloves contained detectable quantities of benzisothiazolinone (range, 0.001-1.48 parts per million [ppm]), bisphenol A (0.01-0.11 ppm), triphenyl phosphate (0.01-2.11 ppm), and triphenyl phosphite (0.001-0.22 ppm). Eighteen (90%) gloves contained mono(2-ethylhexyl) maleate (0.001-0.14 ppm) and 3 (15%) contained tricresyl phosphate (0.001-0.002 ppm). Conclusions: Known allergens were present in all 20 PVC gloves. However, the detected levels were mostly low and their relationship with sensitization and elicitation thresholds requires further study.

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来源期刊
Dermatitis
Dermatitis 医学-皮肤病学
CiteScore
5.30
自引率
11.50%
发文量
251
审稿时长
>12 weeks
期刊介绍: Dermatitis is owned by the American Contact Dermatitis Society and is the home journal of 4 other organizations, namely Societa Italiana di Dermatologica Allergologica Professionale e Ambientale, Experimental Contact Dermatitis Research Group, International Contact Dermatitis Research Group, and North American Contact Dermatitis Group. Dermatitis focuses on contact, atopic, occupational, and drug dermatitis, and welcomes manuscript submissions in these fields, with emphasis on reviews, studies, reports, and letters. Annual sections include Contact Allergen of the Year and Contact Allergen Alternatives, for which papers are chosen or invited by the respective section editor. Other sections unique to the journal are Pearls & Zebras, Product Allergen Watch, and news, features, or meeting abstracts from participating organizations.
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