Omaima Mohammed Abdelwahed, Basma Emad Aboulhoda, Maryse Youssef Awadallah, Sarah Ali Abdelhameed Gouda, Hend Abdalla, Laila Rashed, Mai Khaled, Emad E Ghobrial, Hadel M Alghabban, Nivin Sharawy
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引用次数: 1
摘要
背景:急性肾损伤(AKI)是脓毒症的常见并发症，具有长期住院的负担。早期预测AKI是干预和改善预后的最有效策略。目的:在我们的研究中，我们旨在通过超声指标(灰度和多普勒指数)、内皮损伤(e -选择素、VCAM-1、ICAM1、血管生成素2、syndecan-1和eNOS)以及炎症生物标志物(TNF-a和IL-1β)来研究联合模型对AKI的预测性能。方法:将60只白化大鼠分为对照组和脂多糖组。分别于AKI后6小时、24小时和48小时记录肾脏超声、生化和免疫组织学指标。结果:AKI后早期内皮细胞损伤及炎症指标明显升高，且与肾体积减小及肾阻力指标升高有显著相关性。结论:采用曲线下面积(area under the curve, AUC)，结合超声和生化指标对联合模型进行分析，对肾损伤的预测价值最高。
Prediction of acute kidney injury using a combined model of inflammatory vascular endothelium biomarkers and ultrasound indices.
Background: Acute kidney injury (AKI) is a common complication of sepsis, with the burden of long hospital admission. Early prediction of AKI is the most effective strategy for intervention and improvement of the outcomes.
Objective: In our study, we aimed to investigate the predictive performance of the combined model using ultrasound indices (grayscale and Doppler indieces), endothelium injury (E-selectin, VCAM-1, ICAM1, Angiopoietin 2, syndecan-1, and eNOS) as well as inflammatory biomarkers (TNF-a, and IL-1β) to identify AKI.
Methods: Sixty albino rats were divided into control and lipopolysaccharide (LPS) groups. Renal ultrasound, biochemical and immunohistological variables were recorded 6 hrs, 24 hrs, and 48 hrs after AKI.
Results: Endothelium injury and inflammatory markers were found to be significantly increased early after AKI, and correlated significantly with kidney size reduction and renal resistance indices elevation.
Conclusions: Using area under the curve (AUC), the combined model was analyzed based on ultrasound and biochemical variables and provided the highest predictive value for renal injury.
期刊介绍：
Clinical Hemorheology and Microcirculation, a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. It includes perihemorheology, i.e., the rheology of fluid and structures in the perivascular and interstitial spaces as well as the lymphatic system. The clinical aspects include pathogenesis, symptomatology and diagnostic methods, and the fields of prophylaxis and therapy in all branches of medicine and surgery, pharmacology and drug research.
The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. The editors of Clinical Hemorheology and Microcirculation are from those countries in Europe, Asia, Australia and America where appreciable work in clinical hemorheology and microcirculation is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Clinical Hemorheology and Microcirculation accepts original papers, brief communications, mini-reports and letters to the Editors-in-Chief. Review articles, providing general views and new insights into related subjects, are regularly invited by the Editors-in-Chief. Proceedings of international and national conferences on clinical hemorheology (in original form or as abstracts) complete the range of editorial features.
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