外泌体在自身免疫性甲状腺疾病中的作用及其机制研究进展。

IF 4.3 4区 医学 Q2 IMMUNOLOGY International Reviews of Immunology Pub Date : 2023-01-01 DOI:10.1080/08830185.2022.2057482
Yuping Chen, Bingtian Dong, Lichun Huang, Jingxiong Zhou, Huibin Huang
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引用次数: 1

摘要

外泌体是一种分布广泛的细胞外囊泡,由于其来源广泛、膜结构稳定、免疫原性低、含有多种生物分子等特点,是目前研究的一大热点。大量文献表明,外泌体和外泌体货物(尤其是microrna)在炎症的激活、肿瘤的发生、细胞的分化、免疫的调节等方面发挥着重要作用。研究发现外泌体可以刺激机体的免疫反应,参与包括自身免疫性疾病在内的多种疾病的发生和发展。此外,外泌体作为各种疾病的治疗工具的潜力也引起了人们的广泛关注。自身免疫性甲状腺疾病(Autoimmune thyroid disease, AITD)是最常见的自身免疫性疾病之一,主要由Graves病(GD)和桥本甲状腺炎(Hashimoto’s thyroiditis, HT)两种疾病组成,影响许多人的健康,具有遗传易感性,但其发病机制仍在探索中。本文从外泌体的相关生物学特性出发,综述了外泌体的研究现状以及外泌体与某些疾病的关系,并结合目前已发表的文献,重点介绍了AITD的情况以及外泌体(包括其囊泡内物质)在AITD中的潜在作用,旨在为AITD的发病机制、诊断或治疗提供新的方向。本文的补充资料可在网上获得。
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Research progress on the role and mechanism of action of exosomes in autoimmune thyroid disease.

Exosomes are widely distributed extracellular vesicles (EVs), which are currently a major research hotspot for researchers based on their wide range of sources, stable membrane structure, low immunogenicity, and containing a variety of biomolecules. A large number of literatures have shown that exosomes and exosome cargoes (especially microRNAs) play an important role in the activation of inflammation, development of tumor, differentiation of cells, regulation of immunity and so on. Studies have found that exosomes can stimulate the immune response of the body and participate in the occurrence and development of various diseases, including autoimmune diseases. Furthermore, the potential of exosomes as therapeutic tools in various diseases has also attracted much attention. Autoimmune thyroid disease (AITD) is one of the most common autoimmune diseases, mainly composed of Graves' disease (GD) and Hashimoto's thyroiditis (HT), which affects the health of many people and has a genetic predisposition, but its pathogenesis is still being explored. Starting from the relevant biological characteristics of exosomes, this review summarizes the current research status of exosomes and the association between exosomes and some diseases, with a focus on the situation of AITD and the potential role of exosomes (including substances in their vesicles) in AITD in combination with the current published literature, aiming to provide new directions for the pathogenesis, diagnosis or therapy of AITD.Supplemental data for this article is available online at.

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来源期刊
CiteScore
11.00
自引率
4.00%
发文量
24
期刊介绍: This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).
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