咪唑 [2,1-b] [1,3,4]- 噻二唑类似物的治疗魅力:专利回顾。

IF 1.8 Q3 PHARMACOLOGY & PHARMACY Pharmaceutical patent analyst Pub Date : 2023-07-01 Epub Date: 2023-09-06 DOI:10.4155/ppa-2023-0006
Anuradha Mehra, Rekha Sangwan, Aryan Mehra, Shivani Sharma, Pankaj Wadhwa, Amit Mittal
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引用次数: 0

摘要

咪唑噻二唑是在 20 世纪 50 年代左右发现的,含有一个咪唑环和一个噻二唑环。咪唑噻二唑具有抗惊厥、强心、消炎、利尿、抗真菌、抗菌和抗癌等多种药理特性。尽管咪唑噻二唑衍生物早在 20 世纪 50 年代就已被发现,但由于缺乏生物利用度、药效和细胞毒性,一直未能进入临床试验阶段。最近的专利文献主要集中在对咪唑噻二唑核心进行结构改造,以克服这些问题。本综述从疾病为中心的角度对2015-2023年的咪唑噻二唑专利进行分析,并了解其在相关疾病中的作用机制。相关已授权专利申请是通过专利数据库、谷歌专利、美国专利商标局、欧洲专利局、世界知识产权组织、Espacenet 和 Lens 查找的。
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Therapeutic charisma of imidazo [2,1-b] [1,3,4]-thiadiazole analogues: a patent review.

Imidazothiadiazole was discovered around the 1950s era, containing an imidazole ring fused to a thiadiazole ring. Imidazothiadiazole exhibit versatile pharmacological properties including anticonvulsant, cardiotonic, anti-inflammatory, diuretic, antifungal, antibacterial and anticancer. Despite of the being discovered in 1950s, the imidazothiadiazole derivatives are unable to being processed to clinical trials because of lack of bioavailability, efficacy and cytotoxicity. The recent patent literature focused on structural modification of imidazothiadiazole core to overcome these problems. This review limelight a disease-centric perspective on patented imidazothiadiazole from 2015-2023 and to understand their mechanism of action in related diseases. The relevant granted patent applications were located using patent databases, Google Patents, USPTO, EPO, WIPO, Espacenet and Lens.

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来源期刊
Pharmaceutical patent analyst
Pharmaceutical patent analyst PHARMACOLOGY & PHARMACY-
CiteScore
1.80
自引率
0.00%
发文量
22
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