Xiaoying Kang PhD, MPH, Alexander Ploner PhD, Bjorn Roelstraete PhD, Jonas F. Ludvigsson MD, PhD, Karin Wirdefeldt MD, PhD
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Risk of Parkinson's Disease in Celiac Disease: A Swedish Population-Based Study
Using a population-based matched cohort design, we assessed the association of celiac disease (CeD) with risk of PD by comparing patients with biopsy-confirmed CeD in Sweden to a biopsy-free population and their unaffected siblings, separately. No overall association was observed but CeD diagnosed before age 60 associated positively with incident diagnosis of PD (hazard ratio [HR] = 1.29; 95% confidence interval [CI]: 1.02–1.62), which was mainly attributed to the significantly elevated risk detected after 10–15 years since biopsy (HR = 1.68; 95% CI: 1.05–2.68). Our findings imply an increased vulnerability to long-term PD development among patients with CeD diagnosed before 60s. ANN NEUROL 2023;94:911–916
期刊介绍：
Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.
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